Patents Represented by Attorney Merial Limited
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Patent number: 7625842Abstract: The invention relates to 5-(oximinoalkyl- and hydrazonalkyl-amino)pyrazole derivatives of formula (I) or salts thereof: formula (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).Type: GrantFiled: December 22, 2006Date of Patent: December 1, 2009Assignee: Merial LimitedInventors: David Chou, Werner Knauf, Michael Maier, Friederike Lochhaas, Karl Seeger
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Patent number: 7608595Abstract: A compound of formula (I); that has the S-configuration at the 4?-position and wherein the bond between carbon atoms 22 and 23 is a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is H, or, for example, unsubstituted or mono- to penta-substituted C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl or C1-C6alkoxy-C1-C6alkyl; R3 is H or, for example, C1-C12alkyl; X is a bond, O, NR4 or S; and Z is C?O, C?S or S02; and, where applicable, E/Z isomers, mixtures of E/Z isomers and/or tautomers, in each case in free form or in salt form; a process for the preparation of and the use of those compounds and their isomers and tautomers; starting materials for the preparation of the compounds of formula (I); pesticidal compositions in which the active ingredient has been selected from those compounds and their tautomers; and a method of controlling pests using those compositions are described.Type: GrantFiled: May 6, 2003Date of Patent: October 27, 2009Assignee: Merial LimitedInventors: Hans Tobler, Fiona Murphy Kessabi
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Patent number: 7608279Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified or weakly purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group comprising an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.Type: GrantFiled: February 7, 2008Date of Patent: October 27, 2009Assignee: Merial LimitedInventors: Alexis Guy Andre Parisot, Stephanie Marie-Catherine Desgouilles-Blechet, Catherine Charreyre
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Patent number: 7605134Abstract: A description is given of compounds of the formula which in the 4?-position has the (S)-configuration and wherein R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is hydrogen, optionally substituted C1-C12alkyl or optionally substituted C2-C12alkenyl; R3 is C1-C12alkyl, optionally substituted C1-C12alkyl, optionally substituted C1-C12alkoxy-C1-C12alkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C2-C12alkenyl; optionally substituted C4-C12cycloalkenyl, optionally substituted C2-C12alkynyl; or R2 and R3 together are a three- to seven-membered alkylene or four- to seven-membered alkenylene bridge in each of which a CH2 group may have been replaced by O, S or NR4; X is O or S; R4 is C1-C8alkyl, C3-C8cycloalkyl, C2-C8alkenyl, C2-C8alkynyl, benzyl or C(?O)—R5; R5 is for example H, OH, SH, C1-C12alkyl, C2-C8alkenyl, C2-C8alkynylyl or C1-C12haloalkyl; and, where appropriate, E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form; to a proType: GrantFiled: August 20, 2002Date of Patent: October 20, 2009Assignee: Merial LimitedInventor: Hans Tobler
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Patent number: 7598364Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.Type: GrantFiled: November 14, 2006Date of Patent: October 6, 2009Assignee: Merial LimitedInventor: Laurent Bernard Fisher
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Patent number: 7582302Abstract: The invention provides a novel method of vaccination of an animal of the felidae family against feline leukemia. The FeLV recombinant vaccine based on viral vector with the aid of a liquid jet needle-free injector can result in distribution of the vaccine essentially in the dermis and the hypodermis of the animal.Type: GrantFiled: June 6, 2005Date of Patent: September 1, 2009Assignee: Merial LimitedInventors: Tesfai Tseggai, Maria Camila Pardo, Alton Timothy Leard
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Patent number: 7576107Abstract: The invention relates to the use for the control of pests, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for their preparation.Type: GrantFiled: February 27, 2003Date of Patent: August 18, 2009Assignee: Merial LimitedInventors: David Teh-Wei Chou, Henricus Maria Marinus Bastiaans, Anke Kuhlmann, Maria-Theresia Thönessen, Stefan Schnatterer, Uwe Döller, Jamin Huang, Karl Seeger, Andrew Scribner, Adalberto A. Perez De Leon
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Patent number: 7563773Abstract: This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent.Type: GrantFiled: April 15, 2005Date of Patent: July 21, 2009Assignee: Merial LimitedInventors: Keith Freehauf, Maryam Moaddeb
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Patent number: 7560456Abstract: The invention relates to 3-pyridylcarboxamide derivatives of formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processes for their preparation.Type: GrantFiled: May 6, 2003Date of Patent: July 14, 2009Assignee: Merial LimitedInventors: Koichi Araki, Tetsuya Murata, Koshi Gunjima, Norihiko Nakakura, Eiichi Shimojo, Dale Robert Mitchell, Henricus Maria Martinus Bastiaans, David Stephen Carver, Daniel Allen, Christian Arnold, Waltraud Hempel, Olga Malsam, Jutta Maria Waibel
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Patent number: 7541432Abstract: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associated R. sanguineus glutamate gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Rhipicephalus sanguineus glutamate gated chloride channels, which will be useful as insecticides.Type: GrantFiled: January 5, 2007Date of Patent: June 2, 2009Assignee: Merial LimitedInventors: Jeffrey W. Warmke, Youfeng Yang, Doris F. Cully, Michel J. Hamelin
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Patent number: 7534559Abstract: Disclosed are plasmids that contain and express in vivo in a feline host cell nucleic acid molecules. The plasmid can include nucleic molecule(s) having sequence(s) encoding infectious peritonitis virus M; feline immunodeficiency virus env, or gag, or pro, or gag and pro, or env and gag and pro; rabies G; or feline leukemia virus env and/or gag. Compositions containing such plasmids, methods of use employing such plasmids, and kits involving such plasmids, are also disclosed.Type: GrantFiled: August 30, 2001Date of Patent: May 19, 2009Assignee: MerialInventors: Jean-Christophe Audonnet, Annabelle Bouchardon, Philippe Baudu, Michel Riviere
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Patent number: 7531186Abstract: The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.Type: GrantFiled: February 20, 2004Date of Patent: May 12, 2009Assignee: Merial LimitedInventors: Albert Boeckh, Luiz Gustavo Cramer, Mark D. Soll
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Patent number: 7531182Abstract: A vaccine against foot-and-mouth disease, using as antigen an efficient amount of empty capsids of the foot-and-mouth virus. The empty capsids are obtained by expressing, in eukaryotic cells, cDNA of the P1 region of the foot-and-mouth virus genome coding for the capsid and cDNA of the region of the foot-and-mouth virus genome coding for protease 3C. The vaccine further includes a carrier or excipient pharmaceutically acceptable in veterinary medicine.Type: GrantFiled: December 20, 2002Date of Patent: May 12, 2009Assignee: Merial LimitedInventors: Andrew Maurice Quatermain King, Alison Jane Burman, Jean-Christophe Francis Audonnet, Michel Francois Antoine Lombard
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Patent number: 7521429Abstract: A compound of formula (I) wherein the bond between carbon atoms 22 and 23 may be a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl, or C2-C12alkenyl; R2 and R3 are, for example, independently of each other hydrogen, C1-C12alkyl, C3-C12cycloalkyl, C2-C12alkenyl, C2-C12alkynyl, aryl or heteroaryl; and, where applicable, to E/Z isomers, mixtures of E/Z isomers, diastereomers and/or tautomers, in each case in free form or in salt form; pesticidal compositions in which the active ingredient has been selected from those compounds and their tautomers; and a method of controlling pests using those compositions are described.Type: GrantFiled: June 15, 2004Date of Patent: April 21, 2009Assignee: Merial LimitedInventors: Thomas Pitterna, Pierre Jung, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Ottmar Franz Hueter
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Patent number: 7517877Abstract: The invention relates to the use for the control of parasites in animals, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to novel 5-substituted-alkylaminopyrazole derivatives and pesticidal compositions thereof, and to processes for their preparation.Type: GrantFiled: February 27, 2003Date of Patent: April 14, 2009Assignee: Merial LimitedInventors: David Teh-Wei Chou, Henricus Maria Martinus Bastiaans, Anke Kuhlmann, Maria-Theresia Thönessen, Stefan Schnatterer, Uwe Döller, Jamin Huang, Karl Seeger, Andrew Scribner, Adalberto A. Perez De Leon
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Patent number: 7514561Abstract: Substituted-acylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, processes for their preparation, compositions thereof and methods for their use for the control of pests, such as arthropods (e.g. insects and arachnids) and helminths (including nematodes).Type: GrantFiled: November 12, 2003Date of Patent: April 7, 2009Assignee: Merial LimitedInventors: Stefan Schnatterer, David William Hawkins, Daniela Jans, Michael Maier, Anke Kuhlmann, Erich Friedrich Sanwald, Maria-Theresia Thönessen, Karl Seeger
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Patent number: 7507416Abstract: The recombinant live vaccine comprises a viral vector incorporating and expressing in vivo a heterologous nucleotide sequence, preferably a gene of a pathogenic agent, and at least one adjuvant compound chosen from the acrylic or methacrylic polymers and the copolymers of maleic anhydride and an alkenyl derivative. It is in particular a polymer of acrylic or methacrylic acid cross-linked with a polyalkenyl ether of a sugar or polyalcohol (carbomer), in particular cross-linked with an allyl sucrose or with allylpentaerythritol. It may also be a copolymer of maleic anhydride and ethylene cross-linked, for example, with divinyl ether.Type: GrantFiled: December 12, 2003Date of Patent: March 24, 2009Assignee: Merial LimitedInventors: Jean-Christophe Francis Audonnet, Jules Maarten Minke
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Patent number: 7504501Abstract: Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).Type: GrantFiled: March 2, 2004Date of Patent: March 17, 2009Assignee: Merial LimitedInventors: Matthew J. Wyvratt, Tesfaye Biftu, Michael H. Fisher, Dennis M. Schmatz
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Patent number: 7504362Abstract: 5-Substituted-sulfonylaminopyrazole derivatives of formula (I): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof, processes for their preparation, and methods for their use for the control of arthropods (including insects and arachnids) and helminths (including nematodes).Type: GrantFiled: November 12, 2003Date of Patent: March 17, 2009Assignee: Merial LimitedInventors: Uwe Döller, David Teh-Wei Chou, Merwyn Steinsberger, Michael Maier, Anke Kuhlmann, Karl Seeger, David William Hawkins, Stanley Thomas Derek Gough, David Treadway Manning
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Patent number: 7476685Abstract: The invention relates to 3-pyridylcarboxamide derivatives of the formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processes for their preparation.Type: GrantFiled: May 6, 2003Date of Patent: January 13, 2009Assignee: Merial LimitedInventors: Koichi Araki, Tetsuya Murata, Koshi Gunjima, Norihiko Nakakura, Eiichi Shimojo, Christian Arnold, Waltraud Hempel, Daniela Jans, Olga Malsam, Jutta Maria Waibel