Abstract: Compounds of the formula I ##STR1## as well as methods for their preparation, their pharmaceutical preparations and their use in therapy, especially as analgesics and as immunosuppressive agents.

Abstract: Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use as analgesics.

Abstract: A topical dressing for dermal or transdermal administration of a substance, comprising a backing structure comprising a disc, a pad containing the active substance, a resilient layer with an adhesive provided on one side thereof, the resilient layer and the adhesive being provided with a cut-out defining a cavity in which the pad is placed, the disc of the backing structure being provided on the side of the resilient layer remote from the side provided with the adhesive and partly covering the resilient layer, and a covering structure having a release layer and a dish, the dish being formed to receive the pad during production and storage of the dressing, said covering structure being provided on the adhesive side of the resilient layer, whereby the backing structure is provided with one or more strips extending outwardly from the periphery edge of the backing disc towards the periphery edges of the resilient layer and in that the cover structure and the backing structure are sealed together within the cavity

Abstract: New compounds of the formula (A) ##STR1## a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.

Abstract: The present invention discloses a new and improved process for the preparation of sameridine and its pharmaceutically acceptable salt.

Abstract: Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use. ##STR1## The compounds of formula I are useful in therapy, especially as analgesics and as immunosuppresive agents.

Abstract: Compounds of the formula I, ##STR1## are NMDA antagonists and useful in the treatment and prevention of nervous system related pathological conditions resulting from overstimulation by excitatory amino acids. Methods for their preparation and pharmaceutical compositions containing them are also comprised according to the invention.

Abstract: The present invention provides non-invasive methods for diagnosing Alzheimer's disease in a living human subject. One method employs a non-invasive automated apparatus which can continuously monitor pupil diameter size over time; repetitively measure pupil diameter size over time for a pre-chosen duration ranging from about less than 1 second to about 5 minutes; and cumulatively record size information as it is obtained over time. A second method employs an apparatus which can repetitively measure pupil constriction velocity for a pre-chosen duration both before and after stimulation by visible light. Both methods require the administration of at least one neural transmitter mediator to a targeted eye of the living subject in an amount insufficient to cause marked changes in pupil diameter size over time in a person who is not afflicted with Alzheimer's disease.

Abstract: The present invention is directed to devices that can be used for repairing cracks that form in the hoof of an animal. Methods for using these devices in repairing cracks are also claimed.

Abstract: Use of a pharmaceutically acceptable salt of ropivacaine for the manufacture of a pharmaceutical preparation with sensoric block and minimal motor blockade.

Abstract: The present invention is directed to methods for immobilizing molecules on surfaces of platinum. Devices having surfaces modified by such methods are also claimed. The method uses an isocyanate or isothiocyanate molecule which is reacted with the platinum to produce immobilized reactive moieties. These moieties are reacted with the molecule to be immobilized.

Abstract: The present invention is directed to methods in which a lithium source and a choline source act synergistically to reduce or eliminate the symptoms associated with bipolar disorder.

Abstract: The present invention is directed to method for chemically converting polyhydric alcohols to a mixture of hydrocarbons and halocarbons. The invention is also directed to a process for converting cellulose or hemicellulose to hydrocarbon fuels.