Patents Represented by Attorney, Agent or Law Firm Michael C. Mayo
  • Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
    Patent number: 5686450
    Abstract: Compositions containing certain sulfur containing compounds and methods of use in the treatment and prevention of cataracts is disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 11, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, William H. Garner, Jaime E. Dickerson, Jr., Marjorie F. Lou
  • Polyethoxylated castor oil products as anti-inflammatory agents
    Patent number: 5686488
    Abstract: Compositions and methods treating inflammation are disclosed wherein the compositions contain a pharmaceutically effective anti-inflammatory amount of a polyethoxylated castor oil.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: November 11, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Daniel A. Gamache, Gustav Graff, Jon C. Nixon
  • Process for preparation of clonidine derivatives
    Patent number: 5684156
    Abstract: A novel process for preparing clonidine derivatives has been discovered which is shorter, less expensive and safer than previously known methods. A new thiourea complex has also been discovered which can be directly cyclized to produce the corresponding heterocyclic product.
    Type: Grant
    Filed: August 31, 1995
    Date of Patent: November 4, 1997
    Inventors: David R. Pierce, William D. Dean, Michael E. Deason
  • Liquid enzyme compositions containing aromatic acid derivatives
    Patent number: 5672213
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: September 30, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Ronald P. Quintana, Bor-Shyue Hong
  • Ethacrynic acid-like compounds and use thereof to treat glaucoma
    Patent number: 5650541
    Abstract: Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: July 22, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventor: Jesse A. May
  • Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
    Patent number: 5646149
    Abstract: Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, George Barnes, Robert J. Collier, Jr.
  • Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
    Patent number: 5643943
    Abstract: Methods for treating vascular inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 1, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Daniel A. Gamache, Mark R. Hellberg, Jon C. Nixon, Gustav Graff
  • Use of amidoamines in ophthalmic compositions
    Patent number: 5631005
    Abstract: The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: May 20, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Nissanke L. Dassanayake, Ronald L. Schlitzer, Joonsup Park
  • Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
    Patent number: 5607966
    Abstract: Compounds having anti-inflammatory and anti-oxidant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: March 4, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Gustav Graff
  • Methods of using liquid enzyme compositions containing mixed polyols
    Patent number: 5605661
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: February 25, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong
  • Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 5604190
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent, and complexing agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 18, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Stable liquid enzyme compositions and methods of use
    Patent number: 5576278
    Abstract: Compositions containing an ophthalmically acceptable enzyme of high purity and integrity in a liquid medium and methods involving the use of these compositions for cleaning a contact lens, and in combination with an antimicrobial agent for the simultaneous cleaning and disinfecting of contact lens are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 19, 1996
    Assignee: Alcon Laboratories, Inc.
    Inventors: Barry F. Van Duzee, Ralph P. Stone
  • Ethacrynic acid-like compounds and use thereof to treat glaucoma
    Patent number: 5506226
    Abstract: Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are capable of effectively penetrating the cornea. Methods of controlling intraocular pressure via topical application of one or more of the compounds to the eye and topical ophthalmic compositions useful in the treatment of glaucoma are also described.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: April 9, 1996
    Assignee: Alcon Laboratories, Inc.
    Inventor: Jesse A. May
  • Surgical handpiece holder
    Patent number: D381421
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: July 22, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Peter D. Casica, James Y. Chon