Abstract: The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for biocides. The nanoparticles are particularly useful in preventing or reducing the uptake of biocides from ophthalmic compositions by contact lenses, when the compositions are applied to the lenses.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
January 17, 2012
Assignee:
Novartis AG
Inventors:
Howard Allen Ketelson, Nissanke L. Dassanayake, Thomas Christopher Carey, David L. Meadows
Abstract: Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide); Z is selected from the group consisting of —CH2CH?CHCH2—, —CH2CH2CH2CH2—, —CH2—C?C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2—; R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3; n is an integer from 1 to 30; x is either 0 or an integer from 2 to 20; y is an integer from 2 to 20; z is either 0 or an integer from 2 to 20; R? is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups; Q1 and Q2 are independently selected from the group consisting of —CH2CH?CHCH2—X, —CH2C?C—CH2—X, —N(R?)2, —N(R?)3, —N(R?)(R?),
Type:
Grant
Filed:
August 5, 2009
Date of Patent:
January 10, 2012
Assignee:
Alcon Research, Ltd.
Inventors:
Ryan DeSousa, Nissanke L. Dassanayake, Howard Allen Ketelson
Abstract: The present invention is directed to an improved process for producing substantially pure fluorescein, as well as to substantially pure fluorescein compositions prepared by the process. The invention is particularly directed to the provision of pharmaceutical compositions for use in angiography. The substantially pure fluorescein produced by the process of the present invention is low in color, low in sodium chloride content, and substantially free of pyridine.
Type:
Grant
Filed:
December 4, 2007
Date of Patent:
July 19, 2011
Assignee:
Alcon Research, Ltd.
Inventors:
Gregory Bydlinski, Robert Gregg Harris, Britt S. Scott
Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
Type:
Grant
Filed:
October 3, 2008
Date of Patent:
January 18, 2011
Assignee:
Alcon, Inc.
Inventors:
Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows