Abstract: Methods and apparatus for eliminating the effects of electrosurgical interference on continuous, heat-based cardiac output measurements employing several procedures, including the steps of (1) supplying power via an isolation transformer and carrier frequency to a catheter-mounted heating element; (2) measuring the voltage and current on the primary side of the isolation transformer; (3) determining the voltage and current on the secondary side of the transformer on the basis of the measured primary side voltage and current; and (4) calculating the power delivered to and resistance of the catheter-mounted heater on the basis of the secondary voltage and current. A heater power waveform generated with this process will be substantially free of electrical interference due to electrosurgical devices. Then, a system transfer function may be produced via signal processing techniques which involve cross-correlating the heater power waveform with the blood temperature waveform.