Patents Represented by Attorney, Agent or Law Firm Michael J. McCarthy
  • In vitro methods for determining in vivo thrombotic events
    Patent number: 6787320
    Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: September 7, 2004
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • Methods and compositions for inhibiting endothelial cell and fibrinogen mediated inflammation
    Patent number: 6676940
    Abstract: The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endothelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Methods of inhibiting endothelial cell and fibrinogen mediated inflammation within a patient by administering a homolog of this invention are also contemplated.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: January 13, 2004
    Assignee: The Scripps Research Institute
    Inventors: Dario C. Altieri, Lucia R. Languino, George B. Thornton
  • Apparatus for in situ manufacture of essence from living, uncut plants
    Patent number: 6447813
    Abstract: The present invention relates to the in situ manufacture of plant extracts from living plants. Since the plant remains intact, a flower or other component of the plant can be extracted one or more times. Following the extraction process, the plant is typically able to continue with its lifecycle. Such extracts have a variety of uses including use for, but not limited to: herbal and homeopathic medicines, hair and skin treatments, and cosmetics. The present invention also relates to apparatus useful for manufacturing plant extracts from living plants.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: September 10, 2002
    Inventor: Brent W. Davis
  • Nuclear targeted peptide nucleic acid oligomer
    Patent number: 6312956
    Abstract: A composition comprising a nuclear localization sequence and a peptide nucleic acid oligomer (NLS-PNA) is described. Uses of the composition include, but are not limited to: regulation of gene expression, gene therapy, and the production of pharmaceutical nucleic acids and proteins. In addition, the NLS-PNA is useful for scientific and therapeutic transfection and expression of nucleic acids in cells types that previously were resistant to transfection and therapy including quiescent cells, differentiated cells, embryonic stem cells, and eukaryotic cells with intact nuclear membranes. The NLS-PNA can be combined with a membrane transport sequence (MTS) forming a novel compound referred to as an MTS-NLS-PNA wherein the MTS provides transport through the cytoplasmic membrane of a cell.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: November 6, 2001
    Assignee: Vanderbilt University
    Inventor: Kirk B. Lane
  • Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
    Patent number: 6277844
    Abstract: The invention provides compounds of the formula (I): wherein R1 is an amino or an alkyl group, optionally substituted with one or more groups selected from C1-C6 alkyl group; R2 is H or halogen; R3 is H, halogen, hydroxyl group, or alkyl group; R4 is H or halogen; and R5 is halogen, preferably chlorine; and salts and prodrugs thereof; and a method of using these compounds for the treatment of cancer.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: August 21, 2001
    Inventors: Sydney Spector, Neil L. Spector
  • Apparatus and process for in situ manufacture of essence from living, uncut plants
    Patent number: 6254896
    Abstract: The present invention relates to the in situ manufacture of plant extracts from living plants. Since the plant remains intact, a flower or other component of the plant can be extracted one or more times. Following the extraction process, the plant is typically able to continue with its lifecycle. Such extracts have a variety of uses including use for, but not limited to: herbal and homeopathic medicines, hair and skin treatments, and cosmetics. The present invention also relates to apparatus useful for manufacturing plant extracts from living plants.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: July 3, 2001
    Inventor: Brent W. Davis