Patents Represented by Attorney, Agent or Law Firm Michael J. Ward
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Patent number: 5976564Abstract: The invention is related to a novel strain(s) of Bacillus thuringiensis in which essentially all of the pesticidal activity of said strain is in the supernatant of a fermentation of said strain. The strain produces a substance which has activity against an insect pest(s) of the order Coleoptera and which enhances the pesticidal activity of a Bacillus related pesticide. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.Type: GrantFiled: October 8, 1997Date of Patent: November 2, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, Anita M. MacMullan, Patricia Ann Lufburrow, Robert L. Starnes, Denise C. Manker
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Patent number: 5976563Abstract: The invention is related to a novel strain(s) of Bacillus thuringiensis in which essentially all of the pesticidal activity of said strain is in the supernatant of a fermentation of said strain. The strain produces a substance which has activity against an insect pest(s) of the order Coleoptera and which enhances the pesticidal activity of a Bacillus related pesticide. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.Type: GrantFiled: October 8, 1997Date of Patent: November 2, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, Anita M. MacMullan, Patricia Ann Lufburrow, Robert L. Starnes, Denise C. Manker
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Patent number: 5955367Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.Type: GrantFiled: April 14, 1998Date of Patent: September 21, 1999Assignee: Abbott LaboratoriesInventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner, Steen Troels J.o slashed.rgensen, Per Lin.ang. J.o slashed.rgensen, B.o slashed.rge Krag Diderichsen
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Patent number: 5948793Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein n, *, R.sup.1, R.sup.2, R.sup.3 and y are specifically defined, or pharmaceutically acceptable salts or prodrugs thereof, which are useful in selectively controlling neurotransmitter release; therapeutically-effective pharmaceutical compositions of these compounds; and use of said compositions to selectively control neurotransmitter release in mammals.Type: GrantFiled: June 7, 1995Date of Patent: September 7, 1999Assignee: Abbott LaboratoriesInventors: Melwyn A. Abreo, David E. Gunn, Nan-Horng Lin, David S. Garvey, Mark W. Holladay, Keith B. Ryther
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Patent number: 5942632Abstract: A solid phase synthesis method and intermediates useful in the process are disclosed for the preparation of diamino diol and diamino alcohol inhibitors of HIV protease.Type: GrantFiled: July 2, 1998Date of Patent: August 24, 1999Assignee: Abbott LaboratoriesInventor: Gary T. Wang
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Patent number: 5942633Abstract: The present invention relates to a process for the selective alkylation of intermediates of betaxolol.Type: GrantFiled: June 19, 1996Date of Patent: August 24, 1999Assignee: Abbott LaboratoriesInventors: Xiu C. Wang, Luping Liu, Ashok V. Bhatia
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Patent number: 5932774Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.Type: GrantFiled: November 6, 1995Date of Patent: August 3, 1999Assignee: Abbott LaboratoriesInventors: David A. Riley, Ashok V. Bhatia, Steven A. Chamberlin, Gregg E. Robinson
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Patent number: 5914328Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.Type: GrantFiled: June 7, 1995Date of Patent: June 22, 1999Assignee: Abbott LaboratoriesInventors: Nan-Horng Lin, Mark W. Holladay, Melwyn A. Abreo, David E. Gunn, Suzanne A. Lebold, Richard L. Elliott, Yun He
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Patent number: 5912162Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.Type: GrantFiled: May 27, 1997Date of Patent: June 15, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
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Patent number: 5905134Abstract: Polymers can be prepared in solution by continuously distilling solvent from a solution of diacid prepolymers.Type: GrantFiled: April 4, 1997Date of Patent: May 18, 1999Assignee: Abbott LaboratoriesInventors: John J. Hufnagel, Ashok V. Bhatia, David A. Riley, Greg E. Robinson
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Patent number: 5891882Abstract: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.Type: GrantFiled: November 21, 1997Date of Patent: April 6, 1999Assignee: Abbott LaboratoriesInventors: Michael D. Meyer, Robert J. Altenbach, Fatima Z. Basha, William A. Carroll, Irene Drizin, James F. Kerwin, Jr., Michael D. Wendt
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Patent number: 5879676Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.Type: GrantFiled: November 10, 1994Date of Patent: March 9, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
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Patent number: 5874601Abstract: A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.Type: GrantFiled: April 5, 1996Date of Patent: February 23, 1999Assignee: Abbott LaboratoriesInventors: William T. Monte, Aline C. Lindbeck
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Patent number: 5874289Abstract: The invention relates to a mutant of Bacillus thuringiensis which produces a larger amount of crystal delta-endotoxin with a greater pesticidal activity as compared to the corresponding parental strain. The mutant may also have a larger crystal size as compared to the corresponding parental strain. The crystal delta-endotoxin produced by the mutant Bacillus thuringiensis will have an activity directed towards the same pest(s) as its parental Bacillus thuringiensis crystal delta-endotoxin. The invention further relates to a method for producing such a mutant, compositions comprising such a mutant as well as methods for controlling a pest(s) using these compositions.Type: GrantFiled: August 28, 1997Date of Patent: February 23, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, Pamela G. Marrone, Jewel M. Payne, Hanne Gurtler, Annette S. Petersen
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Patent number: 5859235Abstract: The invention relates to a novel substance with activity against insect pests of the order Diptera. The invention further relates to the substance which acts together with a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties. The invention further relates to a novel strain(s) of Bacillus thuringiensis which produces such a substance. The invention further relates to pesticidal compositions comprising the substance and a pesticidal carrier, or the substance and a Bacillus related pesticide, a chemical pesticide and/or a virus with pesticidal properties as well as methods of using the pesticidal compositions to control a pest.Type: GrantFiled: July 11, 1994Date of Patent: January 12, 1999Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, William D. Lidster, Carmen Sanchez Lopez
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Patent number: 5807574Abstract: The present invention relates to novel compositions of and methods of manufacture of controlled release formulations obtained by mixing molten drugs with molten additives to produce homogeneous drug-additive composites.Type: GrantFiled: June 20, 1997Date of Patent: September 15, 1998Assignee: Abbott LaboratoriesInventors: Howard Cheskin, Thomas J. Hale, Kurt G. Van Scoik, Ji Zhou
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Patent number: 5801046Abstract: Novel bacterial isolates of B. thuringiensis are disclosed which have enhanced toxicity with respect to previously resistant or insufficiently susceptible insect species, including, but not limited to, Plutella xylostella, Spodoptera frugiperda and Spodoptera exigua, as well as certain secondary pests such as Trichoplusia ni. Such isolates may be characterized by their possession of a particular subset of the genes coding for the various B. thuringiensis .delta.-endotoxin proteins and by a characteristic plasmid profile, or array, known to be associated therewith.Type: GrantFiled: February 10, 1995Date of Patent: September 1, 1998Assignee: Abbott LaboratoriesInventors: David R. Wilcox, Robert A. Smith, Terry A. Benson
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Patent number: 5801250Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.Type: GrantFiled: December 13, 1996Date of Patent: September 1, 1998Assignee: Abbott LaboratoriesInventors: Patricia A. Oliver-Shaffer, Bikshandarkoil A. Narayanan, James E. Resek, Pulla Reddy Singam
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Patent number: 5770431Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.Type: GrantFiled: May 3, 1995Date of Patent: June 23, 1998Assignee: Abbott LaboratoriesInventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
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Patent number: 5767144Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.Type: GrantFiled: May 30, 1995Date of Patent: June 16, 1998Assignee: Abbott LaboratoriesInventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen