Abstract: A process for sterilizing a polysaccharide composition containing chitosan, a chitosan derivative or a chitin derivative without substantially degrading the polysaccharide. The process has the steps of blending the polysaccharide in a solvent to form a solution or suspension; sterilizing the solution or suspension; dissolving suspended particles, if present; and then aseptically adjusting the pH of the sterilized solution. There is additionally provided a polyol stabilizing agent suitable for the polysaccharide composition.

Abstract: Copolymers formed from dimethacrylates of polyalkylene glycols and vinylic reactive silicones having up to 20 silicon atoms in the substantial absence of additional cross-linking agents. The copolymers may include a hydrophilicity-modifying monomer. The preferred silicon is TRIS (i.e., 3-methacryloxypropyl tris(trimethylsiloxy) silane), while the preferred polyalkylene glycol is polypropylene glycol dimethacrylate. The copolymers are especially suited to use in the fabrication of soft contact lenses because of the good durability and high oxygen permeability and transmissibility. Oxygen transmissibilities of greater than 70 barrers/mm are preferred.

Abstract: Contact lenses, especially toric and bifocal, which are rotationally stabilized and methods of stabilizing contact lenses. Contact lenses are stabilized, with respect to rotation while in place on the eye, by providing the lenses with a non-circular shape. In a preferred embodiment, a toric contact lens is rotationally stabilized by providing the lens with an oval shape. Also disclosed are methods of providing non-circular lenses with appropriate shapes for proper fit to a patient's eye.

Abstract: An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: An article treatment system which provides improved solution mixing and concentration uniformity. The treatment system includes a container, a closure and a channel for guiding fluid flow. The treatment system is especially advantageous for use with effervescent tablets and for use in treating contact lenses. Cleaning and disinfecting of articles is improved by use of a tubular channel which guides upwardly gas and other components released from an effervescent tablet which is located at the bottom of the treatment container. The upward central flow through the channel induces a downward flow between the container walls, the exterior walls of the channel, and the article-retaining means and towards the bottom of the container.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: The present invention provides a self-supporting laminate filter medium having an electret lofty spunbond web and an electret microfiber web, wherein the spunbond web has a density between about 0.01 g/cm.sup.3 and about 0.1 g/cm.sup.3.

Abstract: Corneal onlays for use in surgical implantation into or onto the cornea of a mammal are described. The corneal onlays according to the invention have an optical axis region with optical characteristics which provide visual acuity therethrough and are comprised of a non-biodegradable non-hydrogel ocularly biocompatible material, characterized in that the onlay has a porosity sufficient to allow passage therethrough of tissue fluid components having a molecular fluid weight greater than 10,000 daltons so as to provide for a flux of tissue fluid between cells anterior of the implanted onlay and cells posterior thereof. The porosity of the optical axis region is such that it allows the flux of tissue fluid components whilst excluding ingrowth of ocular tissue. The onlay is further characterized by being adapted for epithelial recolonization.

Abstract: The invention provides a perforated nonwoven web fabricated from a bonded thermoplastic polymer web. The perforated nonwoven web contains a multitude of self-sustaining sustaining perforations that are substantially free of melt-fused edges and can be characterized as stretch-opened perforations. The invention further provides a process for producing the perforated nonwoven web.

Abstract: The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerisation product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.

Abstract: The present invention provides a liquid distribution layer for absorbent articles which exhibits directional liquid distribution properties and has desirable physical integrity. The liquid distribution layer is a nonwoven web of substantially continuous microfibers that has its fibers substantially aligned along one planar dimension of the web, wherein the fibers are hydrophilically modified or hydrophilic. Additionally, the liquid distribution layer may have an increasing fiber alignment gradient as well as a decreasing fiber thickness gradient in the direction of the web thickness. Further provided are suitable processes for producing the liquid distribution layer.

Abstract: The present invention provides a barrier laminate having a barrier layer and a lofty crimped-fiber nonwoven web layer, which laminate provides a foam-like resiliency, cloth-like texture and liquid barrier property. The barrier layer of the laminate is selected from films, microfiber nonwoven webs and laminates thereof, and the crimped-fiber web layer, which contains a structural fiber component and an heat-activatable adhesive component, has substantially uniformly distributed interfiber bonds. Additionally provided are thermoformed articles from the laminate and a thermoforming process for producing the articles.

Abstract: The present invention relates to polymerisable derivatives of carbohydrates comprising a compound of formula (I)R.sup.1 --(COO--Alk).sub.m -(OCONH--R).sub.n -(NHCO).sub.p Y--Z (I)whereinR.sup.1 is a radically polymerisable hydrocarbon group; m, n and p are 0 or 1; Alk is alkylene having up to 10 carbon atoms; R is a diradical, having up to 20 carbon atoms, of an organic diisocyanate; Z is a monovalent radical, minus a single hydroxy group, of a mono-, di- or tri-saccharide, of an oligosaccharide, of a cyclodextrin (CD) or of an anhydrosaccharide; and Y is --O-- or --NH--; with the proviso that when p is zero, m and n are also zero and Y is --NH--; to homopolymers, copolymers, block copolymers, graft copolymers and polymeric networks thereof, to moulded articles, for example contact lenses or biomedicinal articles, comprising the mentioned polymers, as well as to processes for the preparation of the mentioned polymers and articles.

Abstract: A package containing an aqueous drug composition containing an insoluble resin comprising benzalkonium salt units in an amount sufficient to inhibit growth of microbes in said aqueous drug solution. Typically, the insoluble resin is a polymer having repeating units of the formula:--?CH.sub.2 --CH(Ar)!--wherein Ar=a group of the formula:-Phe-CH.sub.2 --N.sup.+ (CH.sub.3).sub.2 R X.sup.-wherein R=long chain alkyl such as C.sub.8-18 alkyl, Phe=phenylene, and X.sup.- is a pharmaceutically acceptable counter anion such as Cl.sup.-.

Abstract: Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.

Abstract: The present invention describes a water-soluble crosslinkable prepolymer that comprises, in the copolymer chain, units derived from the following monomeric structural units: a vinyl lactam (a), vinyl alcohol (b), optionally a lower alkanecarboxylic acid vinyl ester (c), a vinylic crosslinking agent (d) and optionally a vinylic photoinitiator (e); a process for the preparation of the novel prepolymers; crosslinked water-insoluble polymeric networks therefrom; hydrogels and moulded articles made from the crosslinked water-insoluble polymeric networks, especially contact lenses; and a process for the manufacture of hydrogels and finished contact lenses using the mentioned crosslinkable water-soluble prepolymers.

Abstract: An apparatus and method for uniformly contacting an article with a treatment solution. Preferred embodiments are methods of uniformly tinting of contact lenses or uniformly surface modifying contact lenses. The method involves suspending the lens in the treatment solution by application of fluid flow, preferably sinusoidal or pulsed, in a direction opposite the stagnant force (i.e., sum of buoyancy and gravity forces) on the article. The fluid flow prevents the lens from contacting the container structure for periods sufficient to cause non-uniform treatment conditions, while continuously mixing the treatment solution to maintain uniform concentrations throughout.