Abstract: The invention provides method for assessing tumorigenicity of mammalian cells by assaying the proteolytic fragments of 120-130 kD alpha-dystroglycan in medium surrounding mammalian cells.
Type:
Grant
Filed:
August 31, 2000
Date of Patent:
January 3, 2006
Assignee:
The Regents of the University of California
Abstract: PCR (polymerase chain reaction) primers for the detection of certain Bacillus species, such as Bacillus anthracis. The primers specifically amplify only DNA found in the target species and can distinguish closely related species. Species-specific PCR primers for Bacillus anthracis, Bacillus globigii and Clostridium perfringens are disclosed. The primers are directed to unique sequences within sasp (small acid soluble protein) genes.
Type:
Grant
Filed:
June 8, 2000
Date of Patent:
October 29, 2002
Assignee:
The Regents of the University of California
Abstract: The present invention provides a novel telomere associated protein (Trf1-interacting nuclear protein 2 “Tin2”) that hinders the binding of Trf1 to its specific telomere repeat sequence and mediates the formation of a Tin2-Trf1-telomeric DNA complex that limits telomerase access to the telomere. Also included are the corresponding nucleic acids that encode the Tin2 of the present invention, as well as mutants of Tin2. Methods of making, purifying and using Tin2 of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of Tin2 are presented.
Type:
Grant
Filed:
June 30, 2000
Date of Patent:
June 25, 2002
Assignee:
The Regents of the University of California