Patents Represented by Attorney, Agent or Law Firm Mollie M. Yang
  • Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
    Patent number: 5428060
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: June 27, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Ducharme, John W. Gillard, Rejean Fortin, Daniel Dube, Yves Girard, Pierre Hamel, Daniel Delorme
  • Phenylnaphthalene hydroxy acids
    Patent number: 5426109
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: June 20, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel
  • Process for 4"-epi-acetylamino-4"-deoxy-5-oximinoavermectin B.sub.1
    Patent number: 5420260
    Abstract: An improved process for formation of a 5-oxime on avermectin derivatives comprises the treatment of the oxo-compound with hydroxylamine in aqueous isopropanol at pH 1.8-2.1.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: May 30, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Raymond Cvetovich
  • Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
    Patent number: 5410054
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: April 25, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Rick Friesen, Robert N. Young, Yves Girard, Marc Blouin, Daniel Dube
  • (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
    Patent number: 5389650
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: February 14, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Richard Frenette, John W. Gillard, John H. Hutchinson, Petpiboon Prasit, Michel Therien
  • (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
    Patent number: 5380850
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: January 10, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Petpiboon Prasit, Rejean Fortin, John H. Hutchinson, Michel L. Belley, Serge Leger, Richard Frenette, John Gillard
  • Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
    Patent number: 5374635
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomemlar nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: December 20, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Serge Leger, John H. Hutchinson
  • Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
    Patent number: 5360815
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: November 1, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Rejean Fortin, Yves Girard, Erich Grimm, John Hutchinson, John Scheigetz
  • Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
    Patent number: 5350744
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: September 27, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel
  • Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
    Patent number: 5334719
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: August 2, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventor: Richard Frenette
  • Indole carbamates as leukotriene antagonists
    Patent number: 5334597
    Abstract: Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: August 2, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Petpiboon Prasit, Marc Blouin
  • Pradimic acids, amides, and pradimicin derivatives
    Patent number: 5326867
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
    Patent number: 5321033
    Abstract: A form of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]- 2,2-dimethylpropanoic acid sodium salt, obtained by freeze or spray drying, is more soluble in water than the crystalline form thereof. The compound is useful as an anti-asthmatic, anti-allergic, anti-inflammatory, or cytoprotective agent. It is also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: June 14, 1994
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Brian Down, John H. Hutchinson
  • Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis
    Patent number: 5314898
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: May 24, 1994
    Assignees: Merck & Co., Inc., Merck Frosst Canada Inc.
    Inventors: John Y. L. Chung, Robert A. Reamer, Yves Girard, Pierre Hamel
  • Antitumor antibiotic BMY-42448
    Patent number: 5270186
    Abstract: An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.
    Type: Grant
    Filed: October 10, 1991
    Date of Patent: December 14, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel R. Schroeder, Kin S. Lam, Grace A. Hesler, Donald R. Gustavson, Koji Tomita, Ronald L. Berry
  • Arylsulfatase from streptomyces
    Patent number: 5270196
    Abstract: The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4'-demethylepipodophyllotoxin glucoside derivative, particularly etoposide in cancer chemotherapy.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: December 14, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Tomokazu Ueki, Satoshi Yamamoto, Koji Tomita, Yasuo Fukagawa, Toshikazu Oki
  • Taxol derivatives
    Patent number: 5248796
    Abstract: The present invention relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives which are useful as antitumor agents and as intermediates for the preparation of 10-desacetoxytaxol. Also disclosed is a novel process for the preparation of 10-desacetoxytaxol which comprises treating hydroxy protected 10-deacetyltaxol with 1,1,2-trifluoro-2-chlorotriethylamine followed by catalytic hydrogenation.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: September 28, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shu-Hui Chen, Vittorio Farina
  • 3-fluorosulfonyloxyceph-3-em compounds
    Patent number: 5245027
    Abstract: 3-Fluorosulfonyloxyceph-3-ems having a protected amino or acylamino group in the 7-position are subject to carbon-carbon bond formation at the 3-position by means of a palladium catalyzed coupling reaction with substituted organostannanes. A process for preparing cefprozil is disclosed.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: September 14, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stephen R. Baker, Chester Sapino, Jr., Gregory P. Roth
  • Pradimicin derivatives
    Patent number: 5227370
    Abstract: The present invention provides pradimicin analogs which exhibit improved water solubility relative to parent compounds. These novel agents are useful in treatment of fungal infections.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: July 13, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hajime Kamachi, Seiji Iimura, Satsuki Okuyama, Shimpei Aburaki, Takayuki Naito, Yasutsugu Ueda, Leonard B. Crast, Jr., Amarendra B. Mikkilineni
  • Process for the preparation of .alpha.-glucosidase inhibitor, pradimicin Q
    Patent number: 5217877
    Abstract: The present invention relates to a novel .alpha.-glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.
    Type: Grant
    Filed: December 11, 1991
    Date of Patent: June 8, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Tomokazu Ueki, Takashi Tsuno, Toshikazu Oki