Patents Represented by Attorney, Agent or Law Firm Mona Anand
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Patent number: 5780604Abstract: Disclosed are the antibacterial compounds having the formulas: ##STR1## or pharmaceutically acceptable salts and esters thereof. Also disclosed are the processes for preparing compounds of formulas (I), and II) of the invention, pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.Type: GrantFiled: September 26, 1997Date of Patent: July 14, 1998Assignee: Abbott LaboratoriesInventors: Yat Sun Or, Richard F. Clark, Daniel T. Chu
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Patent number: 5773421Abstract: Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.Type: GrantFiled: December 21, 1995Date of Patent: June 30, 1998Assignee: Abbott LaboratoriesInventors: Lisa A. Alder, Marianna Jackson, Neal S. Burres, James B. McAlpine, Jill E. Hochlowski, Larry L. Klein, Paul A. Lartey, Clinton Yeung
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Patent number: 5767096Abstract: Antimicrobial compounds having the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and C.sub.1 -to-C.sub.4 alkanoyl;R.sup.3 and R.sup.4 are selected from the group consisting of(a) R.sup.3 is hydrogen and R.sup.4 is hydroxy,(b) R.sup.3 is hydroxy and R.sup.4 is hydrogen,(c) R.sup.3 and R.sup.4 taken together are .dbd.O; or selected from the group consisting of hydrogen and hydroxy; andR.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R.sup.5 and R.sup.6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.Type: GrantFiled: July 12, 1996Date of Patent: June 16, 1998Assignee: Abbott LaboratoriesInventors: Jill E. Hochlowski, Marianna Jackson, James B. McAlpine, Ronald R. Rasmussen
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Patent number: 5760198Abstract: A process for the preparation of 4"-deoxyerythromycins, having the formula: ##STR1## wherein R is H or OH, and R.sup.1 is H or loweralkyl by treatment of the 2'-O-acetyl-4"-imidazolylthionocarbonyl-erythromycin starting material with the radical initiator 4,4'-azobis-(4-cyanovaleric acid), H.sub.3 PO.sub.2 and an organic base in a water-miscible solvent and optionally eliminating the 2'-O-acetyl group. In a preferred embodiment, the water-miscible solvent is an alcohol and the deoxygenation and deacetylation is carried out in one step.Type: GrantFiled: January 17, 1997Date of Patent: June 2, 1998Assignee: Abbott LaboratoriesInventors: Shyamal I. Parekh, Alexandra E. Graham, Michael John Dipierro, Albert V. Thomas, David A. Riley
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Patent number: 5756473Abstract: An antibacterial compound is disclosed having the formula: ##STR1## wherein R.sub.1 is loweralkyl or a pharmaceutically acceptable salt, ester or prodrug thereof, processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.Type: GrantFiled: November 21, 1995Date of Patent: May 26, 1998Assignee: Abbott LaboratoriesInventors: Jih-Hua Liu, Joseph E. Celebuski
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Patent number: 5750510Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity.Type: GrantFiled: April 4, 1997Date of Patent: May 12, 1998Assignee: Abbott LaboratoriesInventors: Richard L. Elliott, Yat Sun Or, Daniel T. Chu, George W. Griesgraber, Jacob J. Plattner, Daisy Pireh
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Patent number: 5747466Abstract: A compound selected from the group: ##STR1## wherein A, B, V, W, X and R.sup.8 are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.Type: GrantFiled: October 10, 1996Date of Patent: May 5, 1998Assignee: Abbott LaboratoriesInventors: Richard L. Elliott, Yat Sun Or, Daisy Pireh, Daniel T. Chu
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Patent number: 5739342Abstract: The present invention relates to an improved process for the preparation of nicotinic acids represented by the following structural formula (I): ##STR1## which are prepared by reacting a nicotinic amide compound having the formula: ##STR2## under acidic conditions with a nitrite salt. In the process of the invention have the groups R.sup.1, R.sup.2, and R.sup.3, in the compounds are independently selected from the group consisting of hydrogen, and halogen atoms and R.sup.4 is selected from the group consisting of hydrogen, lower alkyl and aryl. The process provides the nicotinic acid compounds in improved yields.Type: GrantFiled: March 3, 1997Date of Patent: April 14, 1998Assignee: Abbott LaboratoriesInventors: Padam N. Sharma, Marazban H. Vandrevala
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Patent number: 5726182Abstract: Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds whereinA is .dbd.CR.sup.6 --;R.sup.1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl;R.sup.2 is selected from the group consisting of ##STR2## R.sup.3 is halogen; R.sup.4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group;R.sup.5 is hydrogen, loweralkyl, halo(loweralkyl), or --NR.sup.13 R.sup.14 ; andR.sup.6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl),as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.Type: GrantFiled: June 7, 1995Date of Patent: March 10, 1998Assignee: Abbott LaboratoriesInventors: Daniel T. Chu, Qun Li, Curt S. Cooper, Anthony K. L. Fung, Cheuk M. Lee, Jacob J. Plattner, Zhenkun Ma, Wei-Bo Wang
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Patent number: 5719272Abstract: A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.Type: GrantFiled: April 2, 1996Date of Patent: February 17, 1998Assignee: Abbott LaboratoriesInventors: Chengxi Yang, Hemantkumar H. Patel, Yi-Yin Ku, Jih-Hua Liu
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Patent number: 5712253Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R.sup.1, R.sup.2, R.sup.3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.Type: GrantFiled: June 18, 1996Date of Patent: January 27, 1998Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Cynthia Burnell Curty, Ramin Faghih, Hugh Nerby Nellans, Albert Christian Petersen
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Patent number: 5711934Abstract: The present invention provides a process for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.Type: GrantFiled: April 11, 1994Date of Patent: January 27, 1998Assignee: Abbott LaboratoriesInventors: Akwete L. Adjei, Dennis Y. Lee, Anthony J. Hlinak
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Patent number: 5710246Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.Type: GrantFiled: March 19, 1996Date of Patent: January 20, 1998Assignee: Abbott LaboratoriesInventors: Kenneth W. Funk, Edwin O. Lundell, Robert B. Miller, Jane L. Chang, Vimal Kishore, James J. Napier, Michael A. Staeger
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Patent number: 5710247Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.Type: GrantFiled: March 19, 1996Date of Patent: January 20, 1998Assignee: Abbott LaboratoriesInventors: Kenneth W. Funk, Edwin O. Lundell, Robert B. Miller, Jane L. Chang, Vimal Kishore, James J. Napier, Michael A. Staeger
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Patent number: 5705190Abstract: A controlled release, oral, solid, pharmaceutical composition for a reduced daily dosage regimen is described where the therapeutic ingredient is a poorly soluble basic drug. The formulation comprises the use of a water-soluble alginate salt, a complex salt of alginic acid and an organic carboxylic acid in admixture with the therapeutic drug. A particular embodiment comprising a once a day dosage form for clarithromycin is also described.Type: GrantFiled: December 19, 1995Date of Patent: January 6, 1998Assignee: Abbott LaboratoriesInventors: Neville W. Broad, Alan F. Carmody, Liam C. Feely, Brian C. Withers
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Patent number: 5703244Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.Type: GrantFiled: November 21, 1996Date of Patent: December 30, 1997Assignee: Abbott LaboratoriesInventors: Qun Li, Wei-Bo Wang, Daniel T. Chu, Lisa Anne Hasvold
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Patent number: 5698522Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A.sup.1 -D.sup.2 -E.sup.3 -G.sup.4 -J.sup.5 -L.sup.6 -M.sup.7 -Q.sup.8 -R.sup.9 -T.sup.10. The compounds of the percent invention are characterized by having an .OMEGA.-amino-functionalized side chain on the D-aminoacyl residue at position 6. The .OMEGA.-amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.Type: GrantFiled: June 1, 1995Date of Patent: December 16, 1997Assignee: Abbott LaboratoriesInventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort, Jonathan Greer
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Patent number: 5696084Abstract: Disclosed are novel antifungal agents having the formula: ##STR1## or a pharmaceutically acceptable acid, ester or prodrug thereof, wherein preferred compounds include those compounds wherein R.sub.1 is selected from the group consisting of --NH.sub.2 ; R.sub.2 is selected from the group consisting of hydrogen, fluoro, and hydroxyl; R.sub.3 is selected from the group consisting of --CH.sub.2 (p-C.sub.6 H.sub.4).sub.3 O(CH.sub.2).sub.3 CH.sub.3, --CH.sub.2 (p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --COO(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(Piperazinyl)(p-C.sub.6 H.sub.4).sub.2 OCH.sub.3, --CO(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.4 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)O(CH.sub.2).sub.6 CH.sub.3, --CO(p-C.sub.6 H.sub.4)(Piperazinyl)(p-C.sub.6 H.sub.4)OCH.sub.3, and --CO(p-C.sub.6 H.sub.4)(Piperazinyl)O(CH.sub.2).sub.6 CH.sub.3 ; and R.sub.Type: GrantFiled: August 16, 1996Date of Patent: December 9, 1997Assignee: Abbott LaboratoriesInventors: Paul A. Lartey, Leping Li, Larry Lewis Klein, Christina Louise Leone, Sheela Albert Thomas, Ming Clinton Yeung, David Allen Degoey, David J. Grampovnik
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Patent number: 5693813Abstract: A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.Type: GrantFiled: February 26, 1997Date of Patent: December 2, 1997Assignee: Abbott LaboratoriesInventors: Wei-Bo Wang, Francis A. J. Kerdesky, Chi-Nung W. Hsiao, Qun Li, Daniel T. Chu
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Patent number: 5687920Abstract: The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.Type: GrantFiled: February 23, 1995Date of Patent: November 18, 1997Assignee: Abbott LaboratoriesInventors: Akwete L. Adjei, Dennis Y. Lee, Anthony J. Hlinak