Abstract: A diode having a reference voltage electrode, a variable voltage electrode, and a diode material between the electrodes. The diode material is formed of at least one high-K dielectric material and has an asymmetric energy barrier between the reference voltage electrode and the variable voltage electrode, with the energy barrier having a relatively maximum energy barrier level proximate the reference voltage electrode and a minimum energy barrier level proximate the variable voltage electrode.

Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.

Abstract: An introducer apparatus with a plurality of cutting edges along the outer surface of the distal end of an introducer with a blunt distal end is disclosed. The introducer may be adapted to extend from and be withdrawn into the sheath. The cutting edges may resect tissue located around the insertion site.

Abstract: The present invention includes cold-adapted, acid-fast bacterium for use as a vaccine and a vaccine vector. In preferred embodiments, the cold-adapted, acid-fast bacterium is a Mycobacteria, for example, Mycobacteria shottsii.

Abstract: Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.

Abstract: A delivery needle apparatus in which a sleeve is fitted over an exterior surface of a delivery needle and methods of manufacturing the same. An elongate medical device may be delivered through the interior of the delivery needle and out of an opening in the distal end of the delivery needle (i.e., the delivery opening). The sleeve may cover a proximal portion of the delivery opening and may align an elongate medical device during insertion and/or withdrawal through the delivery opening.

Abstract: An isolation system for use in damping and isolating low frequency oscillations and shock loads between two members. An exemplary application is a seat isolation system for use with a vehicle such as a lawn mower. The seat isolation system may include two or more isolators interposed between a chassis of the vehicle, and a seat (e.g., operator's seat). The isolators may permit attenuation of shock or low frequency oscillation inputs via damping and isolation in both vertical and horizontal (fore-and-aft and side-to-side) directions. In some embodiments, the isolators include an elastomeric element that provides the seat with six degrees of freedom.

Abstract: The present invention include a method of protecting an animal against Lawsonia intracellularis infections, the method including administering a dose of live virulent L. intracellularis to the animal, allowing a subclinical L. intracellularis infection to develop in the animal, and administering one or more antibiotics to the animal, wherein the one or more antibiotic is administered in a dose sufficient to abbreviate the subclinical L. intracellularis infection.

Abstract: Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies.

Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

Abstract: Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels in subjects in need thereof are disclosed herein. The methods can be useful for subjects having age related decline in testosterone, exercise induced decline in testosterone, and/or hypogonadism.

Abstract: The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

Abstract: Disclosed are photosensitizers that include a polyol moiety covalently bonded to a fused aromatic moiety. Also disclosed is a method for improving UV laser ablation performance of a coating, such as a cationic UV curable coating, by incorporating an oxalyl-containing additive into the cationic UV curable or other coating. Oxalyl-containing sensitizers having the formula Q-O—C(O)—C(O)—O—R1, wherein Q represents a fused aromatic moiety and R1 is an alkyl or aryl group, are also disclosed, as are oxalyl-containing oxetane resins, oxalyl-containing polyester polyols, and cationic UV curable coating formulations that include oxalyl-containing additives.

Abstract: Coating compositions containing coalescents and a latex polymer, wherein the coalescent has a volatile organic content of less than about 50% and is dispersible in the coating composition.

Abstract: A vehicle including a linkage-based motion control system for varying a parameter (e.g., velocity) of the vehicle as a geometric relationship between a vehicle input (e.g., velocity control lever) and a vehicle output (e.g., drive train) is modified. In one embodiment, the control system provides a linkage that allows a fixed level of input applied to the control lever to produce a repeatable output to a variable drive unit even as the drive unit is moved relative to the control lever.

Abstract: D-ribose, given in doses of five to 15 grams daily, reduces or prevents the occurrence of atrial fibrillation in persons experiencing atrial fibrillation.

Abstract: A vehicle including a linkage-based motion control system for varying a parameter (e.g., velocity) of the vehicle as a geometric relationship between a vehicle input (e.g., velocity control lever) and a vehicle output (e.g., drive train) is modified. In one embodiment, the control system provides a linkage that allows a fixed level of input applied to the control lever to produce a repeatable output to a variable drive unit even as the drive unit is moved relative to the control lever. In another embodiment, an adjustable stop for use with setting a terminal position of a control lever (e.g., a velocity control lever) is provided. Accordingly, the maximum potential speed of the vehicle may be adjusted (e.g., reduced) without altering the speed of the vehicle engine.

Abstract: A face mask support for continuous positive airway pressure comprises a circumferential band with biasing means support at the crown of the head on the medial line of the head. The circumferential edge of the cap extends from just below the forehead of a patient to below the inion protrusion at the nape of the neck. A biasing means which is preferably of length of spring steel is formed so as to extend from the biasing means support hold a nasal or face mask apposed to the face of a patient. The circumferential band is stabilized by a band extending from the circumferential band at the region of the ear to the biasing means support.

Abstract: A wet well apparatus, and installation method therefore, that includes a cylindrical body extending between a first end and a second end along a body axis defining an interior material holding volume and a base form closing the first end of the cylindrical body to define a base interior volume adjacent the interior material holding volume of the cylindrical body. The base form is configured to receive a flowable fill material in the base interior volume.

Abstract: An adapter apparatus and methods for using in providing such adapter apparatus include providing a substrate having a plurality of openings defined therethrough. A plurality of conductive elements are mounted within corresponding openings thereof using a curable material.