Abstract: The present invention is directed to compounds and methods for the treatment of cancer. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. The compounds used in accordance with this invention may be provided in a pharmaceutical composition for treatment of metastatic cancer.

Abstract: Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.

Abstract: Medical devices and methods for reducing localized fibrosis at the site of the medical device.

Abstract: A breakaway connector for use with a medical (e.g., catheter) or other fluid system. The connector may include two couplers that engage one another via a substantially frictionless retention device. In one embodiment, the retention device includes a biased cylindrical roller attached to one coupler that contacts an outer surface of the other coupler. The outer surface may include a grooved surface to receive the roller when the couplers are fully attached.

Abstract: Branching catheter systems with diagnostic components for detecting and isolating fluid flow problems (e.g., leaks, occlusions, etc.) and methods for detecting and isolating fluid flow problems are disclosed. Among the fluid flow problems that may potentially be detected are leaks in the branching catheter systems (e.g., cuts, disconnected components, etc.). Another fluid flow problem that may be detected using the diagnostic systems of the present invention is the presence of occlusions or other blockages that prevent fluid flow within the catheter systems. In addition to identifying that a problem exists, the diagnostic components may preferably also be used to identify the location of the fluid flow problem as discussed herein. Connectors for use in the branching catheter systems are also disclosed.

Abstract: A medical device known as an implantable therapeutic substance delivery device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and many other conditions. The therapeutic substance delivery device has a permanent magnet solenoid pump that is energy efficient, accurate, small, compatible with therapeutic substances, and has many other improvements. The implantable therapeutic substance delivery device has a housing, a therapeutic substance reservoir, a power source, electronics, and a permanent magnet solenoid pump. The therapeutic substance reservoir is configured to contain a therapeutic substance and is coupled to the housing. The power source is carried in the housing to power the electronics and solenoid pump. The electronics are coupled to the solenoid pump and the solenoid pump is coupled to the therapeutic substance reservoir.

Abstract: Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources.

Abstract: A control system for use with a ground maintenance vehicle such as a lawn mower. The control system may include one or more control handles movable between a neutral position and at least a first drive or reverse position. The system may further include a biasing mechanism operable to bias the control handle from the first drive position to the neutral position. The biasing mechanism may be pre-deflected when the control handle is in the neutral position, yet provide little or no biasing effect to the handle until the handle is moved towards the first drive position.

Abstract: The present invention provides composite biological devices that include biological material as an integral component thereof. The devices can be used for producing hydrogen gas, for example.

Abstract: A method and/or system of adjusting light output intensity of a display system includes providing a display system that provides information to a user. Dilation of a pupil of the user is monitored (e.g., using an imaging device) and adjustment of the light output intensity of the display system is performed as a function of the monitored dilation of the pupil of the user. Yet further, for example, such adjustment of light output intensity may also be performed as a function of the monitored ambient light intensity in addition to the monitored dilation of the pupil of the user.

Abstract: The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-?36 activity. The invention further provides methods for identifying agents that bind to such polypeptides, methods for detecting such polypeptides, and methods for altering the activity of such polypeptides. Also provided are antibodies that specifically bind to an amino acid sequence depicted at SEQ ID NO:1, or an immunogenic fragment thereof, and methods for making and using such antibodies.

Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.

Abstract: A removable cover for attachment to a structure such as a housing. In one embodiment, the cover extends over a mechanical drive system of an implement. The exemplary cover may be used to shield a driven pulley and at least a portion of an associated belt of a lawn mower cutting deck when the cover is attached to the deck. The cover may, at one end, include one or more portions configured to engage the housing. At a second end, the cover may include a resilient lip that, at least in one embodiment, is defined by an opening formed in the cover. The lip may selectively interlock with an anchor attached to the housing to secure the cover relative to the deck.

Abstract: A blower/vacuum having an air inlet cover and a blower tube, both of which attach to a blower housing for operation of the blower/vacuum in a blower mode. The air inlet cover may removably attach to both the blower housing and to the blower tube. In some embodiments, operation of the blower/vacuum may generally be restricted unless both the blower tube and the air inlet cover are first installed. The blower/vacuum may further be adapted to operate in a vacuum mode by removing the air inlet cover and blower tube and replacing the same with a vacuum tube assembly and a vacuum collection container, respectively.

Abstract: The present invention provides coating compositions that include reactive diluents and have high performance, low VOC levels, and low irritation levels.

Abstract: The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of the antibody with PF4 or heparin alone. The monoclonal antibody of the invention also binds specifically with PF4 in a complex with other glycosaminoglycans besides heparin, and also activates platelets. The monoclonal antibody of the invention is useful in methods for diagnosing and treating HIT/HITT in a mammal. A humanized version of the monoclonal antibody of the invention is also included, along with a process for humanizing the monoclonal antibody of the invention.

Abstract: A medical catheter having an elongate body, a first expandable balloon and a filter assembly. The filter assembly includes an expandable filter having a first portion coupled to a portion of the medical catheter and a second portion positioned around at least a portion of the first expandable balloon to form a channel between the filter assembly and the first expandable balloon. The filter assembly can further include struts coupled to the second portion of the expandable filter, where the struts tether the second portion of the expandable filter to the elongate body adjacent the proximal end of the first expandable balloon. The first expandable balloon can be used in procedures to dilate blood vessels, including those that deploy stents, where the expandable filter assembly captures particles, including embolic particles, from the blood during the procedure.

Abstract: A medical electrical lead includes a lead body, an inner assembly extending through the lead body, an outer insulative layer covering the inner assembly, and an electrode mounted outside the exterior surface of the outer insulative layer. The inner assembly includes an elongate inner structure forming a lumen, an elongate conductor extending along an outer surface of the inner structure, and a conductive fitting coupled to the elongate conductor.

Abstract: An adjustable shelving storage system for use in industrial, commercial and home settings were available space is limited, the storage system having supports arms with a unique bracket for releasable attachment to side rail uprights whereby the support arms may be reversed for flat storage when not used. The system is provided in wall-mounted, floor mounted and mobile versions.