Patents Represented by Attorney, Agent or Law Firm Nadege M. Lagneau
  • Chimeric analgesic peptides
    Patent number: 6759520
    Abstract: The present invention provides a novel chimeric peptide containing an opioid peptide moiety and a nociceptive peptide moiety for producing analgesia.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: July 6, 2004
    Assignee: The New England Medical Center Hospitals, Inc.
    Inventors: Daniel B. Carr, Andrzej W. Lipkowski, Richard Kream, Aleksandra Misicka-Kesik
  • Quinolinones and uses thereof
    Patent number: 6713462
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: March 30, 2004
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolines and uses thereof
    Patent number: 6706699
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: March 16, 2004
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • &agr;-O-linked glycoconjugates, methods of preparation and uses thereof
    Patent number: 6660714
    Abstract: The present invention provides novel &agr;-O-linked glycoconjugates such as &agr;-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the &agr;-O-linked glycoconjugates.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: December 9, 2003
    Assignee: Sloan Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Dalibor Sames, Samuel Hintermann, Xiao-Tao Chen, Jacob B. Schwartz, Peter Glunz, Govindaswami Ragupathi, Philip O. Livingston, Scott Kuduk, Lawrence Williams
  • Method for the modification of alcohols on polymer supports
    Patent number: 6548661
    Abstract: The present invention provides a polymer-linked composition having the structure: wherein RA and RB are each independently a linear or branched chain alkyl or an aryl group; wherein is a polymeric support; wherein L is a linker selected from the group consisting of a single bond; a saturated or unsaturated oligomethylene chain, etc., a 1,4-phenylene; or a 1,4-phenylenemethylene moiety, said moiety being optionally substituted by at least one linear or branched alkyl, alkoxy group etc.; and wherein RC is a linear or branched acyclic, cyclic or multicyclic moiety, said moiety being optionally unsaturated and/or substituted by at least one hydrogen, ORi, alkyl, etc.; wherein Ri is hydrogen, CHO, COORii, or a substituted or unsubstituted linear or branched chain alkyl, etc.; wherein if RC is cyclic, said moiety is optionally aromatic and/or heterocyclic; or if multicyclic, said moiety is optionally a fused multicyclic, fully or partially aromatic and/or heterocyclic.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: April 15, 2003
    Assignee: Sloan Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Kenneth A. Savin, Jonathan C. G. Woo