Abstract: An apparatus and method for controlled release of nucleotides from electrodes utilizing potential difference for use in delivering the nucleotide into an organism. The frequency, duration and rate of release may be specifically controlled to obtain optimal release of the nucleotide. The apparatus and method may be used in conjunction with methods for electroporation, wherein the nucleotide may transit the cell membrane, and move into the cell. Alternatively, the apparatus and method may be used in conjunction with complexes of DNA and lipids or other carriers, which complexes will transit the cell membrane and move into the cell. The apparatus and method may be used for gene therapy, for use in treatment of any of a wide variety of diseases.

Abstract: An apparatus for electrochemical detection of DNA hybridization utilizing oligonucleotide-containing polymer-coated electrodes, and an apparatus for electrochemical detection of nucleic acids in flowing streams using doped polymer-coated electrodes. Also provided are methods for detection of DNA hybridization and for detection of nucleic acids in flowing streams.

Abstract: A hyper-sound detection and ranging system for remote wind measurements that provides all three orthogonal components of a three dimensional wind field on a single transmission pulse utilizing simultaneous beams of acoustic waves. The present invention measures atmospheric wind by transmitting a broad beam acoustic pulse to illuminate a zone of the atmosphere, and then measuring the Doppler shifts in the backscatter signals arrived at the system from various directions along the broad beam projection utilizing simultaneous receiving beams of narrow beamwidth. The simultaneous receiving beams are obtained by means of a hybrid of analog and digital beamforming technologies that enables simultaneous formation of a programmable number of beams in any direction within the designed fields-of-view.

Abstract: A locking device for use in connection with an energy controlling apparatus, such as a valve, or regulator, to prevent unauthorized persons from changing the position of a rotatable shaft of the apparatus that controls the amount of energy that flows through the apparatus. The locking device includes a handle used to manually set the position of the shaft. It also includes a gear that is rotatably mounted in the handle and is fixed to the shaft of the apparatus. A first locking mechanism carried by the handle mechanically and selectively couples the handle and the gear through a key access to the lock. A spring-biased ratchet mechanism may be provided to permit rotation of the shaft in one direction only. A personal locking mechanism with only a single key is selectively lockable to the handle so that in the locked position it prevents access to the first locking mechanism. An alternative locking mechanism selectively couples the handle and the gear through a keyless access to the lock.

Abstract: An apparatus for detecting structural integrity and localizing leaks from fluid storage holding structures, such as fuel supply storage tanks and fluid carrying pipelines. The invention comprises at least one reference electrode or material and at least one sample collection container containing an absorbent/adsorbent material. The sample container is positionally moveable within at least one perforated pipe disposed below the fluid holding structure. Leaking substances from the holding structure flow into the perforated pipe, into the sample container, and are absorbed/adsorbed. By removing the sample container from the pipe, the quantity, quality and position of the leak is detected.

Abstract: An interchangeable and rotatable jewelry display for beads or ornaments, and a method of displaying and rotating interchangeable ornaments.

Abstract: A portable oxidant generator for generating a chlorine or chloro-oxygen solution suitable for sterilizing contaminated drinking water, thereby providing potable water. The oxidant generators include an electrolytic chamber and a power supply or source. The chamber holds a salt brine solution such that the solution is in contact with an anode and cathode included in the chamber. The power supply provides electrical charge which is passed between the anode and cathode through the salt brine solution. In the preferred embodiment of the present invention, the power supply includes an energy storage device that is charged to predetermined voltage. The energy storage device is preferably charged by a generator that converts mechanical energy into electrical energy. The present invention includes a brine storage compartment in the cap.

Abstract: The invention relates to transgenic mammals characterized by 5-HT3 receptor over-expression in the central nervous system (CNS) . The mammals have particular utility as models for studying the role of 5-HT3 receptors in the CNS, especially for the study of reward pathways for alcohol and other substances of abuse.

Abstract: An apparatus and method for partitioning a vehicle, particularly for use with public safety vehicles, in transporting prisoners, a prisoner and canine, or a prisoner and equipment. The invention comprises a partition mounted adjustably on a mounting bracket. The partition slides along the mounting rails for side to side adjustment. The partition is hinged at the mounting bracket to allow opening of the partition flat against the wall.

Abstract: An amusement device comprising a modularized pod, in which one or more riders sit and are restrained, and which spins under power about a horizontal axis according to the passenger's active control. The riders control the spinning of the pod, either forward or backward, by pressing buttons on the passenger's handgrips located inside the pod. The modularized pod may be used in conjunction with many different types of amusement devices, including, but not limited to roller coasters, carousels, Ferris wheels, virtual reality units, centrifugal tumblers. The modularized pod may also be used in conjunction with flight and space training and simulation units.

Abstract: The invention provides segments of HSV-1 and HSV-2 glycoprotein B which include antigenic epitopes in the gB amino-proximal region that react with human antibodies in a type-specific manner, and epitopes in the gB carboxy-proximal region that cross-react with HSV-1 and HSV-2 antibodies.

Abstract: Constructed wetlands, utilizing a plurality of cells, in which nitrification and denitrification occurs simultaneously, at low flow rates and lower temperatures. The constructed wetlands provides improved remediation in a shorter period of time.

Abstract: A protective bag for safely servicing a tire. The bag comprises a flexible fabric that is preferably permeable to air, and is fastened around a tire using a plurality of securely fastenable straps.

Abstract: A transcutaneous therapeutic formulation comprising marijuana and a carrier for the treatment of pain, inflammation, arthritis and related disorders in humans and animals.

Abstract: Interferometric auto-correlation is obtained using third-order (.chi..sup.(3)) nonlinearities. The nonlinear signal is separated from the linear interferometric response in order to extract information about the amplitude and the chirp of the ultrashort pulses. In one technique, cross-polarized beams are provided to eliminate the linear response. In another technique, electronic filtering is used. Electronic filtering provides substantial reduction of cost, size and complexity over conventional second harmonic generator crystals.

Abstract: Methods to recover nitroamines from energetic pyrotechnic materials yielding useable by-products and producing zero waste. The methods are used on materials containing HMX and RDX.

Abstract: A pressure transformer is provided having a housing, with a rotating group disposed therein, an adjustable port plate is disposed between a barrel of the rotating group and a head portion of the housing. The barrel has a plurality of pistons slideably disposed in cylinders defined in the barrel. The cylinders each define a cylinder port that is in intimate contact with the port plate. The port plate has three arcuate slots defined therein and spaced from one another along a predetermined circumference. Each arcuate slot has a leading edge and a trailing edge. Likewise each of the cylinder ports has a leading edge and a trailing edge. The shape and orientation of the leading edges and trailing edges of the cylinder ports and the arcuate slots are the same. During relative rotation between the cylinder ports and the arcuate slots, the leading edges of the cylinder ports and the leading edges of the arcuate slots are radially concurrent.

Abstract: An apparatus and method for aerosolizing and dispensing powders utilizing the forces of pressurizing and depressurizing gas loaded into powder agglomerates located in an enclosed powder chamber. Methods include administering peptides, genes, vitamins, and polymers into the peripheral lung. Also describes powder supply apparatus and method for single dose and repetitive applications.