Patents Represented by Attorney Nancy K. Brennan

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  • Quinazoles useful as modulators of ion channels
    Patent number: 8343980
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 1, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus Gonzalez, III, Dean Wilson, Andreas Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin Petzoldt, Lev T. D. Fanning, Timothy Neubert, Roger Tung, Esther Martinborough, Nicole Hilgraf
  • Heterocycles useful as modulators of ion channels
    Patent number: 8329702
    Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: December 11, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Lev T. D. Fanning, Paul Krenitsky, Pramod Joshi
  • Pyrimidines useful as modulators of voltage-gated ion channels
    Patent number: 8324220
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 4, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Mitchell Wilson, Esther Ann Martinborough, Timothy Donald Neubert, Andreas P. Termin, Jesus E. Gonzalez, III, Nicole Hilgraf
  • Modulators of ATP-binding cassette transporters
    Patent number: 8314256
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: November 20, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Anna Hazlewood
  • Quinazolines useful as modulators of ion channels
    Patent number: 8283354
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: October 9, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Modulators of ATP-binding cassette transporters
    Patent number: 8242149
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: August 14, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida Ruah, Anna Hazlewood, Peter Grootenhuis, Jinglan Zhou
  • Modulators of cystic fibrosis transmembrane conductance regulator
    Patent number: 8188283
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 29, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Hayley Binch, Peter D. J. Grootenhuis, Sara S. Hadida Ruah, Jinglan Zhou, Anna Hazlewood, Lev T. D. Fanning
  • Quinazolines useful as modulators of voltage gated ion channels
    Patent number: 8158637
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: April 17, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Lev T. D. Fanning, Paul Krenitsky, Andreas Termin, Pramod Joshi, Urvi Sheth
  • Quinazolines useful as modulators of ion channels
    Patent number: 8153642
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: April 10, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus Gonzalez, III, Dean Wilson, Andreas Termin, Peter Grootenhuis, Yulian Zhang, Benjamin Petzoldt, Lev Fanning, Timothy Neubert, Roger Tung, Esther Martinborough, Nicole Hilgraf
  • Processes for the facile synthesis of diaryl amines and analogues thereof
    Patent number: 8034950
    Abstract: The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: October 11, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John R. Snoonian, Patricia Ann Oliver-Shaffer
  • Quinazolines useful as modulators of ion channels
    Patent number: 7928107
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 19, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth