Abstract: The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.

Abstract: A device and method of correcting a spinal defect in a patient employs the use of shape memory material in a spinal correction device. The shape memory material may be transitioned between a flexible martensitic state to allow shaping of the spinal correction device and a rigid austenitic state to apply corrective forces to the spine. The shape memory material may be transitioned to the flexible martensitic by applying a coolant, such as cold gas, directly or indirectly to the shape memory material to transfer heat away from the material. The cooling device and method may allow for in-vivo shaping of the spinal correction device while inserted in the body and attached to bone anchors by cooling the spinal correction device after insertion.

Abstract: The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2R?). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2? using yeast surface display to generate mutants with increased affinity for IL-2R?.

Abstract: A ratchetable open-ended wrench includes a handle for a hand to grasp, a wrench head located on one end of the handle, and a fastener room located in the wrench head for accommodating a workpiece to be rotated. The wrench head further includes a first jaw having a first driving wall, a second jaw having a second driving wall facing the first driving wall, an inner wall extending from the second driving wall into the second jaw, a concavity, an auxiliary jaw retracting opening, an auxiliary jaw capable of longitudinally sliding into the auxiliary jaw retracting opening in an elastic way, and an auxiliary jaw limiting member coupled to a limiting slot. The auxiliary jaw further includes an exterior end having a pillow in contact with the driving wall and a pushing surface for working together with the first jaw to grip the workpiece under operation, an interior end, and a limiting slot.

Abstract: A first aspect of the invention relates to a combination comprising 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabinofuranosyl-cytosine, or a metabolite thereof, or a pharmaceutically acceptable salt thereof, and a cytotoxic agent selected from: (a) a HDAC inhibitor; and (b) a topoisomerase inhibitor selected from etoposide, topotecan and SN-38, or a prodrug thereof. A second aspect relates to a pharmaceutical product comprising (i) 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabinofuranosyl-cytosine, or a metabolite thereof, or a pharmaceutically acceptable salt thereof, and (ii) a cytotoxic agent selected from: (a) a HDAC inhibitor; and (b) a topoisomerase inhibitor selected from etoposide, topotecan and SN-38, or a prodrug thereof, as a combined preparation for simultaneous, sequential or separate use in therapy.

Abstract: A fuel cell vehicle is provided that can suppress uneven torque. The fuel cell vehicle 1 includes a motor 4; a fuel cell 10; a battery 3; a battery drive unit 21 for driving the motor 4 using electricity from the battery 3 so as to serve as an battery drive mode, in which case the initialization of the fuel cell 10 to generate electricity is not complete; a fuel cell drive unit 22 for driving the motor 4 using electricity from the fuel cell 10 and battery 3 so as to serve as a fuel cell drive mode, in which case the initialization of the fuel cell 10 to generate electricity is complete; and a torque upper limit control unit 23 for controlling a torque upper limit value of the motor 4 under the battery drive mode and fuel cell drive mode.

Abstract: An apparatus for dispensing liquid fuel comprises a plurality of inlet valves, each connected in-line with a respective inlet pipe in fluid communication with a respective source of a specific liquid fuel. A plurality of outlet valves are also provided, each connected in-line with a respective outlet pipe. A respective fuel hose is in fluid communication with each of the outlet pipes. The apparatus further comprises a coriolis flow meter located between the inlet valves and outlet valves, the coriolis flow meter providing a flow signal indicative of flow therethrough. A controller is operative to receive the flow signal and control the valves such that selected inputs of specific liquid fuels are dispensed to at least one of the fuel hoses. In accordance with an exemplary embodiment, the selected inputs of specific liquid fuels may include individual liquid fuels and blended combinations thereof.

Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.

Abstract: A method of completing a transaction at a point-of-sale terminal using payment information contained on a wireless unit of a customer. The method comprises providing a point-of-sale terminal capable of wirelessly connecting with a wireless unit of a customer desiring to complete a transaction. The point-of-sale terminal is used to perform at least one of reading a barcode displayed on the wireless unit containing short range network pairing information, or displaying a barcode containing short range network pairing information for reading by the wireless unit, to thereby establish a short range wireless network between the point-of-sale terminal and the wireless unit of the customer. Via the short range wireless network, transaction data is received from the wireless unit of the customer containing payment information. The transaction data is then used to effect payment for the transaction and thereby complete the transaction.

Abstract: Various embodiments of the present invention provide an insulated structural panel including a superinsulating, desiccant-filled, vacuum-sealed insulating panel sandwiched between a pair of composite panels. The composite panels are configured to impart structural strength to the panel without introducing heat transfer pathways through the vacuum-sealed insulating panel. The desiccant material disposed within the vacuum-sealed insulating panel is capable of absorbing moisture within the vacuum established within the vacuum-sealed insulating panel and thereby reducing the degradation of the vacuum-sealed panel's insulating capacity.

Abstract: A handrail or a swing gate for fall restraint equipment comprising an outer rail constructed from a single, continuous piece of tubular metal, a midrail constructed from a single, continuous piece of tubular metal, and a toeboard constructed from a single, continuous piece of sheet metal, where the outer rail is constructed to receive portions of the midrail and toeboard for an integral construction.

Abstract: A locking system includes a carrier member at least one locking member extending from the rod. The carrier member is movable between a first locked position in which the locking member engages a locking receptacle to maintain a container cover in a closed position and a second unlocked position in which the locking member disengages from the locking receptacle and the cover is movable between the closed and open position. The locking system includes a blocking member at a second end of the carrier member. The blocking member is movable between a first engaged position in which the rod abuts a portion of the blocking member and maintains the elongate rod in the first locked position and a second disengaged position in which the rod disengages from the blocking member and a biasing unit urges the rod in the second unlocked position.

Abstract: A work light assembly for use with a hand drill or like rotary tool having a work light, a side handle assembly, and an attachment assembly, where the work light is removably secured to a portion of the rotary tool.

Abstract: A call control method for an Internet Protocol (IP)-based mobility service is provided. The call control method for ensuring service continuity in a mobile communication service environment, includes: receiving a call signal message including permanent IP addresses and transport IP addresses from a transmitter terminal and a receiver terminal, and acquiring the permanent IP addresses and the transport IP addresses of the transmitter terminal and the receiver terminal; and performing call control between the transmitter terminal and the receiver terminal on the basis of the transport IP addresses and the permanent IP addresses of the transmitter terminal and the receiver terminal.

Abstract: An electric motor is coupled to driving wheels 2, 2. When a slippage of the driving wheels 2, 2 is detected, the electric motor 5 produces a regenerative torque to suppress the slippage of the driving wheels 2, 2. The regenerative torque is controlled in a variable manner according to an index parameter that indicates a road surface condition. Thus, when the slippage of the driving wheels occurs, the slippage of the driving wheels is suppressed according to the road surface condition by a regenerative operation of the electric motor coupled to the driving wheels.

Abstract: The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.

Abstract: Provided are a cooling device and an electric vehicle using the cooling device. The cooling device is used for cooling a switching module containing a switching element as a heating element. The cooling device includes a cooling liquid channel having a plurality of cooling fins through which the cooling liquid flows. The cooling fins have a cut-off portion at the position corresponding at least to a center portion of chips constituting the switching module in the flow direction of the cooling liquid. A chamber is formed in the cooling liquid channel by the cut-off portion.

Abstract: A fuel cell vehicle has a fuel cell for generating electric power by being supplied with a reactive gas, an electric storage device, a first power supply line connected to the fuel cell, a second power supply line connected to the electric storage device, and a main DC-to-DC converter for performing bidirectional voltage conversion between the first power supply line and the second power supply line, an electric motor to propel the vehicle and a first electric accessory connected to the first power supply line, a second electric accessory having at least a portion connected to the second power supply line.

Abstract: An electroluminescent device is provided. The electroluminescent device includes an intrinsically conductive polymer layer having a thickness of from about 0.1 to about 3 microns and an elongation less than about 100%; and a phosphor layer having a thickness from about 20 microns to about 70 microns. The electroluminescent device demonstrates a loss of brightness of less than about 10% after undergoing repeated creasing, crushing, flexing, twisting, abrading, and/or stretching.

Abstract: A mobile digging and backfill system for removing and collecting material above a buried utility. The system comprises a mobile chassis, a collection tank mounted to the chassis, a water pump mounted to the chassis for delivering a pressurized liquid flow against the material for loosening the material at a location, a vacuum pump connected to the collection tank so that an air stream created by the vacuum pump draws the material and the fluid from the location into the collection tank, and at least one backfill reservoir mounted to the chassis for carrying backfill for placement at the location.