Patents Represented by Attorney Oona Manzari
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Patent number: 7989656Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.Type: GrantFiled: May 25, 2010Date of Patent: August 2, 2011Assignee: Abbott LaboratoriesInventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
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Patent number: 7910742Abstract: Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.Type: GrantFiled: September 29, 2006Date of Patent: March 22, 2011Assignee: Abbott LaboratoriesInventors: Michael D. Wendt, Chaohong Sun, Daryl R. Sauer, Steven W. Elmore, Aaron R. Kunzer
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Patent number: 7842681Abstract: Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti-apoptotic Bcl-2 family protein members is disclosed.Type: GrantFiled: September 5, 2007Date of Patent: November 30, 2010Assignee: Abbott LaboratoriesInventors: Steven W. Elmore, Saul Rosenberg, Gary Gordon
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Patent number: 7777076Abstract: Macrocyclic compounds of formula (I), in which B1 and X1 taken together are alkylene which is unsubstituted or substituted with ?O and having one CH2 moiety unreplaced or replaced with CH?CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.Type: GrantFiled: May 17, 2006Date of Patent: August 17, 2010Assignee: Abbott LaboratoriesInventors: Steven W. Elmore, Christopher L. Lynch, Xilu Wang
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Patent number: 7754886Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.Type: GrantFiled: February 3, 2009Date of Patent: July 13, 2010Assignee: Abbott LaboratoriesInventors: David J. Augeri, Steven A. Baumeister, Milan Bruncko, Daniel A. Dickman, Hong Ding, Jurgen Dinges, Stephen W. Fesik, Philip J Hajduk, Aaron R Kunzer, William J. Mcclellan, David D. Nettesheim, Thorsten K. Oost, Andrew M. Petros, Saul Howard Rosenberg, Wang Shen, Sheela A. Thomas, Xilu Wang, Michael D. Wendt
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Patent number: 7750004Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.Type: GrantFiled: July 7, 2006Date of Patent: July 6, 2010Assignee: Abbott LaboratoriesInventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
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Patent number: 7667039Abstract: The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.Type: GrantFiled: May 18, 2006Date of Patent: February 23, 2010Assignee: Novartis AGInventors: Carlos Garcia-Echeverria, Frédéric Stauffer, Pascal Furet
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Patent number: 7390805Abstract: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.Type: GrantFiled: March 14, 2007Date of Patent: June 24, 2008Assignee: Novartis AGInventors: Guido Bold, Hans-Georg Capraro, Giorgio Caravatti, Peter Traxler
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Patent number: 7345088Abstract: A pharmaceutical composition for treatment of malignancies, in particular a malignant disease which is associated with the development of bone metastases or excessive bone resorption, comprises in combination a bisphosphonates, COX-2 inhibitor and/or a taxol or derivative thereof for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonates, an effective amount of a COX-2 inhibitor and/or and effective amount of a taxol or derivative thereof.Type: GrantFiled: October 18, 2002Date of Patent: March 18, 2008Assignees: Penn State Research Foundation, Novartis AGInventors: Jonathan Green, Allan Lipton, Lois Mary Witters
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Patent number: 7329661Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.Type: GrantFiled: July 26, 2007Date of Patent: February 12, 2008Assignee: Novartis AGInventors: Hans Michael Buerger, Giorgio Caravatti, Juerg Zimmerman, Paul William Manley, Werner Breitenstein, Margaret Amelia Cudd
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Patent number: 7326699Abstract: The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.Type: GrantFiled: May 13, 2002Date of Patent: February 5, 2008Assignee: Novartis AGInventors: Hans-Georg Capraro, Pascal Furet, Carlos Garcia-Echeverria, Paul William Manley
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Patent number: 7323469Abstract: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumor.Type: GrantFiled: February 20, 2004Date of Patent: January 29, 2008Assignee: Novartis AGInventors: Guido Bold, Hans-Georg Capraro, Giorgio Caravatti, Peter Traxler
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Patent number: 7312216Abstract: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.Type: GrantFiled: June 7, 2006Date of Patent: December 25, 2007Assignee: Novartis AGInventors: Hans M Buerger, Giorgio Caravatti, Uerg Zimmermann, Paul W Manley, Werner Breitenstein, Margaret A Cudd