Patents Represented by Attorney P. R. Robbins, Berliner & Carson, LLP Harder

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  • Oxidizing reagent for use in oligonucleotide synthesis
    Patent number: 5783684
    Abstract: Oxidizing compositions particularly for use in automated oligonucleotide synthesis containing a mixture of KI and I.sub.2 in solution, in equilibrium with KI.sub.3. One preferred composition contains 1.75% KI.sub.3 (providing 0.69% KI and 1.06% I.sub.2) in tetrahydrofuran/pyridine/water (93/5/2, v/v). These formulations enable synthesis of oligonucleotides of significantly higher quality than the currently employed formulation comprising 3% I.sub.2 in tetrahydrofuran/pyridine/water (74/21/2, v/v).
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: July 21, 1998
    Assignee: Beckman Instruments, Inc.
    Inventors: Meda Parameswara Reddy, Firdous Farooqui, Maged A. Michael