Abstract: Carbon monoxide poisoning of anode catalysts in phosphoric acid fuel cells reduces the cell performance. The carbon monoxide absorbs onto the catalyst, blocking hydrogen oxidation sites. A carbon monoxide tolerant platinum-tantalum alloyed catalyst includes between about 2 wt % and about 50 wt % platinum, between about 2 atom % and 10 atom % tantalum deposited on a support. This catalyst is particularly useful in fuel cell system applications where the fuel stream may contain carbon monoxide.