Patents Represented by Attorney Pasternak Patent Law

Find this attorney in the Justia Lawyer Directory

  • Biodetectors targeted to specific ligands
    Patent number: 8349602
    Abstract: The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a molecular switching mechanism to express a reporter gene upon interaction with target substances. The invention further relates to methods using such biodetectors for detecting and quantifying selected substances with high specificity and high sensitivity.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: January 8, 2013
    Assignee: Xenogen Corporation
    Inventors: Pamela R. Contag, David A. Benaron, Christopher H. Contag
  • Methods for targeted cleavage and recombination of CCR5
    Patent number: 8349810
    Abstract: Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, as well as polynucleotides encoding same. Fusion proteins comprising cleavage half-domains are used in pairs to reconstitute a functional cleavage domain. In these fusion proteins, the zinc finger domain can be N-terminal to the cleavage half-domain, or the cleavage half-domain can be N-terminal to the zinc finger domain.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: January 8, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Jeffrey C. Miller, Lei Zhang
  • Targeted integration into the locus
    Patent number: 8329986
    Abstract: Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into a plant Zp15 locus, for example, for expression of a polypeptide of interest.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: December 11, 2012
    Assignees: Dow AgroSciences, LLC, Sangamo BioSciences, Inc.
    Inventors: Holly J. Butler, David R. Corbin, Yannick Doyon, Zhifang Gao, Vipula K. Shukla, Fyodor Urnov, Sarah E. Worden
  • Zinc finger proteins and method for inactivating a dhfr gene in a chinese hamster ovary cell
    Patent number: 8313925
    Abstract: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: November 20, 2012
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller
  • Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins
    Patent number: 8268618
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: September 18, 2012
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Therapy of malignant neoplasias
    Patent number: 8268888
    Abstract: The present invention provides a 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine for the preparation of a pharmaceutical composition for the treatment of malignant neoplasia. Moreover, the invention provides a method for the treatment of malignant neoplasia, the method comprising the steps of administering 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine to a subject in need thereof and a pharmaceutical composition comprising 3-iodo-L-phenylalanine or 4-iodo-L-phenylalanine.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: September 18, 2012
    Inventor: Samuel Samnick