Patents Represented by Attorney Patentique PLLC
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Patent number: 8247188Abstract: The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.Type: GrantFiled: August 17, 2006Date of Patent: August 21, 2012Assignee: Fasgen Diagnostics, LLCInventors: Susan Medghalchi, Jennifer L. Aldrich
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Patent number: 8142788Abstract: The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in part on the use of two or more peptide domains, each with a different sequence, from the PRRSV GP5 protein ectodomain. Compositions and methods comprising polypeptides containing the two or more domains, or nucleic acids encoding them, are described.Type: GrantFiled: April 29, 2008Date of Patent: March 27, 2012Assignee: MJ Biologics, Inc.Inventor: Byoung-Kwan Kim
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Patent number: 8012688Abstract: Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can be electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.Type: GrantFiled: August 12, 2010Date of Patent: September 6, 2011Assignee: Life Technologies CorporationInventors: Mark G. Erlander, Ranelle C. Salunga
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Patent number: 7951841Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.Type: GrantFiled: June 20, 2005Date of Patent: May 31, 2011Assignee: University of WashingtonInventors: Krzysztof Palczewski, Matthew Batten
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Patent number: 7950876Abstract: A socket wrench attachment (SRA) is connected by a circular array of bolts (28) connecting the mounting flange (30) to the rotary output member (22) on a rotary output shaft (20). The shaft (20) is a part of a rotary drive mechanism (12) which is mounted for longitudinal travel along a tower (14).Type: GrantFiled: October 21, 2008Date of Patent: May 31, 2011Inventor: Paul W. Suver
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Patent number: 7928204Abstract: The invention relates to a Bacillus spore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific for Bacillus spores relative to the vegetative form of the cells. The antigen is detectable on ungerminated spores. The antibodies may be used to detect the presence of Bacillus spores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising the antibodies which may be used in the detection methods of the invention.Type: GrantFiled: September 23, 2005Date of Patent: April 19, 2011Assignee: Tetracore, Inc.Inventors: Beverly L. Mangold, Jennifer L. Aldrich, William Max Nelson
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Patent number: 7930105Abstract: Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages and/or grades of breast cancer.Type: GrantFiled: November 28, 2007Date of Patent: April 19, 2011Assignees: bioTheranostics, Inc., The General Hospital CorporationInventors: Xiao-Jun Ma, Dennis C. Sgroi, Mark G. Erlander
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Patent number: 7879555Abstract: Method and compositions related to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can be electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.Type: GrantFiled: November 10, 2009Date of Patent: February 1, 2011Assignee: Life Technologies CorporationInventors: Mark G. Erlander, Ranelle C. Salunga
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Patent number: 7776537Abstract: This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention may be advantageously applied to both the diagnosis and prevention of PRRSV infection.Type: GrantFiled: May 21, 2007Date of Patent: August 17, 2010Assignee: Regents of the University of MinnesotaInventor: Han-Soo Joo
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Patent number: 7772374Abstract: The invention relates to spore specific antibodies. Compositions and methods relating to the antibodies are provided along with the hybridomas that produce the antibodies. The antibodies are specific for the spores of Bacillus anthracis relative to the vegetative form of the cells. The antibodies are also specific for the spores relative to other Bacillus spores and cells. The antibodies may be used to detect the presence of Bacillus anthracis spores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising these antibodies which may be used in the detection methods of the invention.Type: GrantFiled: May 11, 2005Date of Patent: August 10, 2010Assignee: Tetracore, Inc.Inventors: Beverly L. Mangold, Jennifer L. Aldrich
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Patent number: 7723039Abstract: Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.Type: GrantFiled: April 29, 2008Date of Patent: May 25, 2010Assignee: MDS Analytical Technologies (US) Inc.Inventors: Mark G. Erlander, Ranelle C. Salunga
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Patent number: 7618783Abstract: The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis-specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnose B. anthracis. Preferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores of B. anthracis, and not to spores of either B. cereus or B. thuringiensis. Antibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed to B.Type: GrantFiled: April 30, 2001Date of Patent: November 17, 2009Assignee: Tetracore, Inc.Inventors: Beverly Lynn Mangold, Jennifer Lynn Aldrich, Thomas W. O'Brien
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Patent number: 7579007Abstract: This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus particles that have been specifically modified to give biological properties different from the virus particles deriving from an unmodified host cell that (i) expresses at least one co-stimulatory molecule and (iia) at least one antigen that can initiate an immune response, and/or (iib) express surface molecules that suppress viral replication.Type: GrantFiled: February 12, 2002Date of Patent: August 25, 2009Assignee: JDM Technologies, Inc.Inventor: Joseph D. Mosca
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Patent number: 7504214Abstract: Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to tamoxifen treatment. The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with ER+ breast cancer with tamoxifen. Additional methods and compositions are provided for predicting tamoxifen responsiveness in cases of ER+ breast cancer by use of three biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while the third biomarker displays decreased expression correlated with tamoxifen response.Type: GrantFiled: December 2, 2003Date of Patent: March 17, 2009Assignee: bioTheranostics, Inc.Inventors: Mark G. Erlander, Xiao-Jun Ma, Dennis C. Sgroi
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Patent number: 7449296Abstract: The invention provides methods, devices, and kits for the detection of a class of porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV, in a biological fluid. The invention is based in part on an agent which binds the nucleocapsid (N) protein of PRRSV. The agent may be an antibody that binds the N protein with specificity. Compositions and devices comprising the binding agent, as well as methods of using it are also provided. Also provided are methods of preparing devices and kits for the practice of the methods.Type: GrantFiled: February 24, 2006Date of Patent: November 11, 2008Assignee: MJ Biologics, Inc.Inventor: Dong-Hyuk Jung