Abstract: A method and apparatus is provided for drilling high-angle, directional and horizontal subterranean wells for hydrocarbon extraction. A drillstring component having at least one helical undercut pumping chamber is described, which drillstring component is designed especially for increased flexibility in directional drilling applications. The undercut pumping chamber of the invention drillstring component is designed to improve volumetric efficiency in removing cuttings from the borehole, and to reduce the incidence of differential sticking or key-seating.

Abstract: The present invention relates to a method of and composition for reducing intraocular pressure. The method comprises administering to a patient requiring such reduction of intraocular pressure a therapeutically effective amount of 12(R)-hydroxy-eicosa-5,8,10,14-tetraenoic acid (12(R)-HETE). The method of the present invention is particularly useful in treatment of all types of glaucoma. The method is also useful in lowering intraocular pressure in preparation for eye surgery, particularly for the removal of cataracts.

Abstract: This invention relates to combinations and methods for the treatment of renal disease, cardiovascular disease and hypertension. More particularly, the invention relates to combinations of renal vasodilators and .alpha..sub.1 -adrenergic or ganglionic blocking agents. According to a preferred embodiment, atriopeptins having renal vasodilator activity are used in combination with .alpha..sub.1 -adrenergic blocking agents for treating renal disease, cardiovascular disease and hypertension. The blocking agent promotes sustained renal vasodilation, thereby enhancing renal blood flow and kidney function.