Abstract: EGF muteins in which the histidine at position 16 is replaced with a neutral or acidic amino acid exhibit activity at pHs lower than obtainable with wild type EGF.
Type:
Grant
Filed:
August 2, 1994
Date of Patent:
August 20, 1996
Assignee:
Chiron Corporation
Inventors:
Guy T. Mullenbach, Jeffrey M. Blaney, Steven Rosenberg