Patents Represented by Attorney Paul F. Prestia
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Patent number: 5851798Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parlinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: January 27, 1997Date of Patent: December 22, 1998Assignee: SmithKline Beecham CorporationInventors: Usman Shabon, Derk Bergsma
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Patent number: 5840768Abstract: Novel pharmaceutical suspensions comprising a pharmaceutically active ingredient suspended in aqueous media with a suspending agent comprising attrited microcrystalline cellulose coprocessed and at least partially surface coated with a calcium sodium alginate salt complex barrier dispersant and readily dispersible and hydratable dry formulations thereof are described and exemplified.Type: GrantFiled: June 4, 1997Date of Patent: November 24, 1998Assignee: FMC CorporationInventors: Edward Selinger, Sheila M. Dell, John A. Colliopoulos, William J. Reilly, Jr.
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Patent number: 5837508Abstract: HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arhritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.Type: GrantFiled: March 6, 1997Date of Patent: November 17, 1998Assignee: Smithkline Beecham CorporationInventors: Anne Romanic Arnold, Anthony Joseph Arleth, Usman Shabon
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Patent number: 5834587Abstract: Human HLTEX11 polypeptides and DNA (RNA) encoding such HLTEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HLTEX11 for the treatment of atherosclerosis, inflammatory conditions, and infections, particularly viral infections, such as AIDS, among others, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HLTEX11 and for detecting altered levels of the polypeptide in a host.Type: GrantFiled: October 8, 1996Date of Patent: November 10, 1998Assignee: SmithKline Beecham CorporationInventors: Winnie Chan, Derk J. Bergsma, Catherine E. Ellis
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Patent number: 4323158Abstract: Glass bottle inspection apparatus including optical neck finish defect detector and mechanism for rotating the container or bottle to facilitate checking of the finish throughout its circumference. Gripping and rotation of the bottle or container is accomplished by a mechanism, adapted to any symmetrical shape, including non-round shapes, which comprises a resilient ring which is lowered vertically over the neck of the bottle or container to be checked when the bottle or container arrives at the test location of the apparatus. The resilient ring is engaged by a non-resilient annular ring which is in turn driven for rotational movement of the assembly. The elevating and lowering mechanism for the annular gripping ring also includes a downwardly biased bearing and flange member to urge the bottle out of engagement with the ring as the ring is raised, following checking.Type: GrantFiled: July 3, 1980Date of Patent: April 6, 1982Assignee: Wheaton IndustriesInventors: Frank H. Wheaton, III, Curtis C. Houghton
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Patent number: 4316197Abstract: Easily removable instrument pen tip comprised of a body formed of resilient plastic with an ink passageway adapted to receive and sealingly engage an ink supply tube associated with a pen arm, the other end of which is adapted to receive and sealingly engage an elongated nib element, such as a stylus or fibrous nib. The pen tip body is a flat shaped member in which the passageway lies. The body may converge toward the ink passageway to serve as a visually indicating pointer. The body may also include locators or positioning ribs and reinforcing ribs. Preferably, the body and passageway include bent sections and the nib element and passageway are adapted for engagement only in the bent section passageway.Type: GrantFiled: August 20, 1979Date of Patent: February 16, 1982Assignee: Graphic Controls CorporationInventors: James R. Hubbard, William A. Tallerico
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Patent number: 4307410Abstract: Disposable instrument pen with integrally-formed spring member simplifies installation and provides its own biasing means for urging the pen nib into engagement with a writing surface and/or for retaining the pen in a pen mounting carriage. In various alternative embodiments, the spring member may consist of a cantilever arm, a torsion bar with end mount fixtures, a helical spring, flared wings, etc.Type: GrantFiled: November 8, 1979Date of Patent: December 22, 1981Assignee: Graphic Controls CorporationInventor: James R. Hubbard
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Patent number: 4306372Abstract: A set of building blocks readily assembled to form a variety of houses comprises several flexible wall elements, flexible roof elements, roof forming elements, roof connecting elements, cubic elements, and base boards which can be connected side by side to construct a base as a ground member of the houses. The wall elements can be bent into different configurations so as to act as side walls at one's desire.Type: GrantFiled: September 15, 1980Date of Patent: December 22, 1981Inventor: Wen-Ping Lin
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Patent number: 4305596Abstract: Improved joint seal for the rotor drive of an eccentric screw machine comprises a sealing cuff of elastomeric or thermoplastic material with a radially exterior rim bead connected to the outer joint sleeve by means of an exterior supporting ring, and a radially interior rim bead with a generally axis-parallel ring apron radially outward thereof. An interior supporting ring with an axis-parallel annular limb connects the radially interior rim bead of the cuff to a coupling rod of the joint with the annular limb of the interior supporting ring clasped between the radially interior rim bead and the ring apron disposed outwardly thereof on the sealing cuff. The radially exterior rim bead may be connected to the joint sleeve by means of an exterior suporting ring similar to the interior supporting ring.Type: GrantFiled: August 17, 1979Date of Patent: December 15, 1981Assignee: Netzsch-Mohnopumpen GmbHInventor: Eugen Unterstrasser
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Patent number: 4303759Abstract: Polyalkylene carbonates are stabilized against oxidative degradation by the inclusion therein of 0.2-10%, preferably 1-5%, of peroxyl-reactive sulphur-containing additive. Such compounds, found to be effective, are 3-t-butyl-4-hydroxy-5-methylphenyl sulfide, diphenyl sulfide, diphenyl sulfoxide, diphenyl sulfone, di-(p-tolyl sulfide) and sulphur.Type: GrantFiled: September 12, 1980Date of Patent: December 1, 1981Assignee: Air Products and Chemicals, Inc.Inventors: Dale D. Dixon, Michael E. Ford
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Patent number: 4300534Abstract: The invention relates to solar collectors which transfer thermal energy from a collector to a point of use by means of a heat exchange fluid. An array of collectors may be provided having a modified system to facilitate convenient assembly into an array and to provide balanced fluid flow across the array. The outlet conduit sized to insure the steady flow of fluid and air thus preventing the accumulation of air to the outlet to block fluid flow.Type: GrantFiled: December 3, 1979Date of Patent: November 17, 1981Assignee: Ametek, Inc.Inventor: John C. Bowen
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Patent number: 4293193Abstract: A group of novel, low temperature liquid crystalline compounds with terminal, primary or secondary amino polar electron donating groups are disclosed. These include, for example, p-alkyl-or alkoxy-phenylcyclohexanes, bicyclohexyls or biphenyl ring systems, substituted at the p' position with alkyl primary or secondary amines, of which one example is p-(4-trans-n-pentylcyclohexyl)benzylamine.Type: GrantFiled: August 15, 1979Date of Patent: October 6, 1981Assignee: Temple UniversityInventors: Mortimer M. Labes, John H. MacMillan
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Patent number: 4282020Abstract: A receiver for waste molten glass, which automatically dumps the glass as cullet in lump or fragment form. The receiver comprises primarily a hopper or bin, with a central partition which divides the hopper into two compartments. The hopper or bin is pivotally mounted for reciprocating pivotal movement about a horizontal line in the plane of the partition such that the compartments formed on either side of the partition are alternately faced upwardly to receive molten glass and cooling water. Molten glass gobs, thus cooled, and water weight that side of the hopper in which they are received, thus causing it to pivot downwardly and thereby to dump cooled cullet in lump form while the alternative compartment is faced upwardly to receive subsequently poured waste molten glass and water until the weight of material in that compartment causes reverse pivotal movement and dumping. The hopper is triangular in vertical cross section, as are the partitioned compartments thereof.Type: GrantFiled: November 25, 1977Date of Patent: August 4, 1981Assignee: Wheaton IndustriesInventor: Frank H. Wheaton
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Patent number: 4278070Abstract: Solar energy collector assembly including a solar energy collector in an enclosed space housing with bottom closure member secured by a snap-fit spring channel and low thermal conductivity mating projection therefor, a collector member securing means comprising a plurality of stiff low thermal conductivity wire retainers and top cover securing and sealing means comprising a seal and clamp engaging the top cover just inward of its periphery, to prevent intrusion of condensate in the enclosed space of the housing.Type: GrantFiled: August 13, 1979Date of Patent: July 14, 1981Assignee: Ametek, Inc.Inventor: John C. Bowen
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Patent number: 4259271Abstract: Improved method for making generally spherical particulate shot-like product comprising permitting a siliceous-aluminous composition of specified characteristics onto a rotating squirrel cage rotor near top dead center thereof and causing said impinging molten material to be projected in droplet form and cooled while suspended in a gaseous cooling medium, such as air, into an amorphous generally spherical product, suitable for use as an abrasive or filler material.Type: GrantFiled: May 4, 1979Date of Patent: March 31, 1981Inventors: L. John Minnick, William C. Webster, Charles L. Smith
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Patent number: 4254002Abstract: The process, and product thereof, in which castable compositions comprising mixtures of 5-15% (by weight) of (1) a monomer or prepolymer mixture of castor oil and a dicarboxylic acid or urethane and (2) a vinyl copolymer mixture such as styrene and divinyl benzene with suitable cross-linking agents are made into highly useful products composed of simultaneously formed interpenetrating polymer networks. This process consists of first raising the temperature of the mixture to initiate polymerization of the vinyl copolymer, then, following phase separation and phase inversion but before gelation occurs, forming a product from the composition and thereafter heating the formed product to effect completion of the polymerization and crosslinking reactions.Type: GrantFiled: February 21, 1979Date of Patent: March 3, 1981Inventors: L. H. Sperling, J. A. Manson, N. Devia-Manjarres
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Patent number: 4075354Abstract: Novel ethynylbenzene compounds and derivatives are described. Their use in the treatment of inflammation is also disclosed.Type: GrantFiled: June 10, 1975Date of Patent: February 21, 1978Assignee: William H. Rorer, Inc.Inventor: Julius Diamond
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Patent number: 4034537Abstract: A method of and apparatus for continuously making liquid filled packages wherein a tube is formed from a web, and, having been filled with liquid, is passed round a first turntable to be pre-shaped into packages and to shape first side walls of the packages. The tube is transversely sealed an cut on the first turntable and then passed round a second turntable to shape second, opposite, side walls of the packages.Type: GrantFiled: September 24, 1975Date of Patent: July 12, 1977Assignee: Altstadter Verpackungs-Vertriebs GmbHInventors: Wilhelm Reil, Jorg Trabitzsch
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Patent number: D262028Type: GrantFiled: March 9, 1979Date of Patent: November 24, 1981Assignee: Ralph McKay LimitedInventor: William M. Johnson