Patents Represented by Attorney, Agent or Law Firm Paul G. Lunn, Esq.
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Patent number: 7892787Abstract: A method of producing somatotropin encompassing the microbiological expression of a recombinant protein containing somatotropin and hybrid polypeptide containing the amino-acid sequence of ubiquitin and the amino-acid sequence of somatotropin.Type: GrantFiled: July 7, 2006Date of Patent: February 22, 2011Assignee: Instytut Biotechnologii I AntybiotykowInventors: Andrzej Plucienniczak, Maria Ludwika Smorawinska, Renata Wolinowska, Diana Mikiewicz-Sygula, Iwona Sokolowska, Natalia Lukasiewicz, Luiza Chojnacka, Grazyna Plucienniczak, Jolanta Kuthan-Styczen, Krystyna Strzezek, Alina Marciniak-Rusek, Anna Kruszynska, Anna Wojtowicz, Anna Mazurkiewicz-Pisarek, Ewa Wojcik
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Patent number: 7868148Abstract: A method is described of obtaining a plasmid contained in a difficult to separate, heterogenous plasmid DNA fraction, particularly one containing various plasmids of similar sizes. Another aspect of the present invention are new plasmids obtained via the method according to the present invention, their derivatives and/or fragments, as well as the application of these products in biotechnology and medicine, particularly gene therapy.Type: GrantFiled: July 7, 2006Date of Patent: January 11, 2011Assignee: Instytut Biotechnologii I AntybiotykowInventors: Andrzej Plucienniczak, Maria Ludwika Smorawinska, Renata Wolinowska, Diana Mikiewicz-Sygula, Agata Jagiello, Radoslaw Kaczanowski, Luiza Chojnacka, Grazyna Plucienniczak, Ewa Zielinska, Krystyna Strzezek, Alina Marciniak-Rusek
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Patent number: 6569419Abstract: A method for promoting the expression of myelin or Protein Zero in Schwann cells using Zcyto7 or IL-17. Zcyto7 or IL-17 are further used to promote myelination of the peripheral nervous system. This is particularly useful in treating diseases dymyelinating diseases such as diabetic neuropathy, Guillain-Barré Syndrome, chronic demyelinating disease, acute demyelinating polyneuropathy and human immunodeficiency viral demyelinating neuropathy or demyelination caused by trauma.Type: GrantFiled: February 27, 2001Date of Patent: May 27, 2003Assignee: ZymoGenetics, Inc.Inventors: Emma E. Moore, Julia E. Novak
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Patent number: 6380361Abstract: An educational kit comprised of novel a novel polypeptide, alpha helical protein-34 (Zalpha34), polynucleotides that encode Zalpha34 and antibodies to Zalpha34. The present invention also relates to polynucleotide and polypeptide molecules for Zalpha34. The polypeptides, and polynucleotides encoding them, are hormonal and may be used to promote spermatogenesis. The present invention also includes antibodies to the Zalpha34 polypeptides, which can be used to inhibit spermatogenesis.Type: GrantFiled: October 24, 2000Date of Patent: April 30, 2002Assignee: ZymoGenetics, Inc.Inventors: Darrell C. Conklin, David W. Taft
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Patent number: 6303770Abstract: Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.Type: GrantFiled: December 10, 1998Date of Patent: October 16, 2001Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Darrell C. Conklin, Julia E. Parrish
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Patent number: 6271343Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions. The polypeptides of the present invention can be used to down-regulate their natural ligands. The polynucleotides and subsequences thereof can be used as diagnostic probes to determine if chromosome 19 is mutated. The antibodies which bind to the polypeptides can be used to purify the receptors and to inhibit the binding of the ligands onto the receptors.Type: GrantFiled: May 1, 1998Date of Patent: August 7, 2001Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Scott R. Presnell, Anna C. Jelmberg, Teresa Gilbert, Theodore E. Whitmore, Donald C. Foster, Robyn L. Adams, Joyce M. Lehner
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Patent number: 6241946Abstract: A method for preparing a solventless protein standard is disclosed in which a solventless dye indicator and a predetermined amount of solventless protein are placed in an appropriate receptacle such as the well of a multiwell plate. This results in a solventless protein standard in which the solventless protein and the solventless dye are contained within the same receptacle. When an appropriate solvent is added to the receptacle, the protein and dye react together to produce a color change which is detectable, and which can be used as a standard for a protein assay using that dye. Also claimed is the solventless protein assay standard produced by the process.Type: GrantFiled: February 10, 1998Date of Patent: June 5, 2001Inventor: David Bickar
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Patent number: 6239254Abstract: The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.Type: GrantFiled: June 4, 1999Date of Patent: May 29, 2001Assignee: ZymoGenetics, Inc.Inventor: Darrell C. Conklin
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Patent number: 5965704Abstract: Novel class II cytokine receptor polypeptides, polynucleotides encoding the polypeptides, an related compositions and methods are disclosed. Th polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in pancreas, small intestine, colon and thymus. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.Type: GrantFiled: August 5, 1997Date of Patent: October 12, 1999Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Robyn L Adams, Anna C. Jelmberg, Theodore E. Whitmore, Theresa M. Farrah
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Patent number: 5945511Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.Type: GrantFiled: October 2, 1997Date of Patent: August 31, 1999Assignee: ZymoGenetics, Inc.Inventors: Si Lok, Choon J. Kho, Anna C. Jelmberg, Robyn L Adams, Theodore E. Whitmore, Theresa M. Farrah
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Patent number: 5939385Abstract: Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.Type: GrantFiled: June 7, 1995Date of Patent: August 17, 1999Assignee: ZymoGenetics, Inc.Inventors: Virender Labroo, Sharon J. Busby
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Patent number: 5935854Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.Type: GrantFiled: April 18, 1995Date of Patent: August 10, 1999Assignee: ZymoGenetics, Inc.Inventors: Cindy A. Sprecher, Donald C. Foster, Kjeld E. Norris
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Patent number: 4856840Abstract: A truck bed extender comprising a platform which is removably attachable to the rear end of a truck; the platform including a plurality of rods with lips, provided on one side of the platform, the lips engaging the rear end of the truck bed when the rods are inserted between the rear end of the truck bed and the front end of a horizontal positioned open tailgate.Type: GrantFiled: November 30, 1987Date of Patent: August 15, 1989Inventor: Dennis S. Hanley