Abstract: A dosage form comprising a composition comprising a drug surrounded by a first coat and a second coat with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.
Abstract: A composition comprising oxybutynin, a dosage form comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
Type:
Grant
Filed:
May 13, 1998
Date of Patent:
September 26, 2000
Inventors:
George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando E. Gumucio
Abstract: The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
Type:
Grant
Filed:
April 4, 1997
Date of Patent:
August 1, 2000
Assignee:
ALZA Corporation
Inventors:
Atul D. Ayer, Andrew Lam, Judy A. Magruder, Lawrence G. Hamel, Patrick S. L. Wong
Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
Type:
Grant
Filed:
June 15, 1999
Date of Patent:
June 20, 2000
Assignee:
Alza Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
Abstract: A dosage form and a method are disclosed and claimed for administering a drug in a sustained and constantly ascending rate per unit time to provide an intended therapeutic effect while concomitantly lessening the development of unwanted effects.
Type:
Grant
Filed:
July 31, 1997
Date of Patent:
March 7, 2000
Assignee:
ALZA Corporation
Inventors:
Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks
Abstract: The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.
Type:
Grant
Filed:
May 12, 1995
Date of Patent:
December 28, 1999
Assignee:
Alza Corporation
Inventors:
Heechung Yang, Vu Anh Nguyen, Liang C. Dong, Patrick S. L. Wong
Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
Type:
Grant
Filed:
June 9, 1997
Date of Patent:
September 21, 1999
Assignee:
ALZA Corporation
Inventors:
Frank Jao, Patrick S. -L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
Type:
Grant
Filed:
February 28, 1997
Date of Patent:
September 7, 1999
Assignee:
Alza Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
Type:
Grant
Filed:
September 22, 1997
Date of Patent:
June 22, 1999
Assignee:
ALZA Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Navjot Chadha, Anthony L. Kuczynski
Abstract: A composition comprising oxybutynin, a device comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
Type:
Grant
Filed:
February 26, 1997
Date of Patent:
June 15, 1999
Assignee:
Alza Corporation
Inventors:
George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando E. Gumucio
Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.
Type:
Grant
Filed:
May 12, 1995
Date of Patent:
May 25, 1999
Assignee:
ALZA Corporation
Inventors:
Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
Abstract: A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
Type:
Grant
Filed:
October 21, 1992
Date of Patent:
April 27, 1999
Assignee:
ALZA Corporation
Inventors:
Liang C. Dong, Michael H. Dealey, Terry L. Burkoth, Patrick S.-L. Wong, Jerry D. Childers, Brian L. Barclay
Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
Type:
Grant
Filed:
June 9, 1997
Date of Patent:
March 2, 1999
Assignee:
ALZA Corporation
Inventors:
Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
Type:
Grant
Filed:
October 21, 1997
Date of Patent:
January 26, 1999
Assignee:
Alza Corporation
Inventors:
Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
Abstract: A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient. A method is provided for administering the drug of the formula for producing the intended therapy.
Abstract: An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.
Type:
Grant
Filed:
May 9, 1995
Date of Patent:
December 1, 1998
Assignee:
ALZA Corporation
Inventors:
Jeri Dawn Wright, Jerry D. Childers, Brian L. Barclay, Patrick S.-L. Wong, Linda E. Atkinson