Abstract: A hands-free gripping device which holds generally cylindrical containers, particularly labware, securely and prevents the container from turning while either opening or closing it. The gripping device features internal deformable ribbing, which secures the container by canting slightly when the container is turned thereby wedging the container in place. This action resists rotation in either direction, making a single device practical for both opening and closing. The device can be mounted on any flat surface and acts as a "third hand" to allow the user to use both hands or to use a single hand to grasp securely the closure being removed or secured from the container. The gripping device facilitates assembly or disassembly of labware devices needing application of torque.

Abstract: A centrifuge rotor overspeed protection system which can operate with rotors of at least two speed ranges. A set of coding elements are provided on the rotors coded to represent the actual maximum safe speed rating of the rotor. An additional set of coding elements coded to correspond to the maximum speed in the lower speed range are also provided such that the rotor can be operated at the maximum speed possible in a prior art centrifuge designed for operation in the lower speed range. The detection circuit for the coding elements automatically adjusts the detection threshold depending on the average values of the sensor output peaks corresponding to the codes.

Abstract: A hybrid fiber-composite centrifuge container having a cylindrical metal sleeve, with a smooth inner surface permanently coupled to the fiber reinforced base. The reinforced base has an open end, a closed end and a cylindrical wall extending between the closed and open ends, with the metal sleeve coupled to the cylindrical wall proximate to the open end forming a sleeve-base interface. The base is formed from a plurality of layers of fiber material wound helically and circumferentially about the axis of the base. Among the plurality of layers of fiber material is a lane-change feature which provides a uniform outer diameter to the cylindrical wall that is coextensive with the interface. The uniform outer diameter helps prevent uncoiling of the plurality of layers of fiber material during centrifugation.

Abstract: A hybrid composite sample holders utilized to further improve overall strength-to-weight of a centrifuge rotor. The holders comprise a metal portion and a fiber composite portion integrally molded.

Abstract: Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface having an interconnected polymeric coating. The interconnected polymeric coating includes a hydrophobic polymeric functionality covalently bound to the interior surface and a hydrophilic polymer interconnected with the hydrophobic polymeric functionality. Exemplary columns are prepared by causing a Si-OH reactive compound, having a hydrophobic polymeric functionality, to react with Si-OH functionalities on the interior surface of capillary columns. Then causing a hydrophilic monomer to polymerize in contact with the hydrophobic polymeric functionality forms a coating of interconnecting hydrophilic and hydrophobic polymers.

Abstract: Procedures such as oligonucleotide, peptide or protein syntheses or sequencing, or immunological or other biospecific assays involving long sequential series of chemical reactions are performed on a solid phase support retained in a pipette tip. The manipulations involved in bringing the solid support into contact with the various reagents or reactants involved in the procedure are performed and controlled by automated instrumentation.

Abstract: The present invention is directed to a synthesis reaction column which can be conveniently implemented in post synthesis procedures. The reaction column is configured to allow easy connection to a syringe and post synthesis reagent container without requiring connection adapters.In one embodiment, the reaction column configured in the form of a cylindrical column containing the solid-phase support and having a narrow bore tube extending at one end. The tube functions as a piercing tip for accessing a septum sealed vial containing post synthesis reagent. In another embodiment, the reaction column is configured in the form of a cylindrical barrel enclosing the solid-phase support and having a threaded mount at one end. To complement the reaction column for post synthesis procedures, a vial having a complementary threaded mount at the opening is used for containing a reagent. This vial is conveniently threaded onto the end of the barrel without adapters.

Abstract: Disclosed are reagents of methods for cleaving and deprotecting insolubilized and protected synthetic oligonucleotides. In a particularly preferred embodiment, the reagent comprises methylamine and t-butylamine.

Abstract: A reciprocating fluid pump having a shaft which dynamically self-corrects angular misalignment between the shaft and its drive mechanism during reciprocative motions. A thrust bearing is utilized to take up axial loading of the shaft to allow the shaft to freely rotate on its supports.

Abstract: An apparatus xxx method of aligning a capillary with respect to a radiation source. More particularly, the capillary is aligned with a laser beam for laser induced fluorescence detection. The light reflection/scatter pattern of the laser beam originating from the capillary wall is utilized to determine optimum alignment. Photosensors may be implemented to detect the scatter pattern which represents optimum alignment. For dynamic alignment during electrophoresis, the photosensors provide feedback to a controller which controls a positioning mechanism for alignment of the capillary.

Abstract: A centrifuge rotor having a balancing ring integrally formed with and raised from the upper surface thereof is manufactured by removing material from the ring to balance the rotor in the upper plane. The balancing ring is on the same radius as the rotor tube cavities and of width less than the diameter of said cavities such that the ring, when the tube cavities are drilled, is broken into segments of precisely known area which make the amount of material to be removed to balance the rotor readily determinable.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording.The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: A cartridge for holding a capillary for electrophoresis. The cartridge has a body defining a passage along which the capillary is threaded. Exits are provided on the body for extending the ends of the capillary to access external fluid sources. The same cartridge may be used for different lengths of capillaries. An aperture is provided on the cartridge for optical detection of electrophoretic separation in the capillary held in the cartridge. The cartridge may include a hollow space defined about the capillary for circulating coolant fluid.

Abstract: Method and apparatus for controlling the angular velocity of a centrifuge tube containing a solute and a solvent to obtain desirable sedimentation behavior and/or diffusion behavior of the solute within the tube during centrifuge operations. In one embodiment, the angular velocity is maintained at a near-maximum value until just before precipitation of a solute component is reached within the tube. The tube angular velocity is then reduced as a function of time so that critical precipitation is approached but never occurs in the tube as the centrifuge process continues. In other embodiments, the net flux of solute particles into a given volume element of the centrifuge tube, or the ratio of net fluxes of two or more solutes into a predetermined volume elements, is caused to be a prescribed function of time. One application of this method is minimization of the time required to obtain a desired density gradient separation by a centrifuge process.

Abstract: A reciprocating shaft which dynamically self-corrects angular misalignment between the shaft and its drive mechanism during reciprocative motions. A thrust bearing is utilized to take up axial loading of the shaft to allow the shaft to freely rotate on its supports.

Abstract: A detection and quantification technique for radioisotope labeled components separated in a capillary separation channel. The section of the separation channel containing the separated components is significantly cooled to substantially eliminate diffusion of the components while detection is being carried out. The section can be frozen and autoradiography technique or solid state electronic imaging technique can be utilized to obtain an image representative of the relative amounts of separated components.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedure including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table for supporting microtiter plates and other fluid receptacles, a movable arm, and a modular mobile pod affixed for reciprocal movement along the arm. The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions.

Abstract: Disclosed is a gel-containing capillary column useful in high performance capillary electrophoresis. A preferred column includes a microcapillary having an interior cavity and a wall with an inner surface; a bifunctional agent comprising a positively charged amine adsorbed to the inner surface of the wall and an active functional group capable of copolymerizing with a polymeric gel material; and a polymer gel material filling the interior cavity of the microcapillary.