Patents Represented by Attorney, Agent or Law Firm Pauline A. Clarke
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Patent number: 6395292Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.Type: GrantFiled: May 4, 2001Date of Patent: May 28, 2002Assignee: Alza CorporationInventors: John R. Peery, Keith E. Dionne, James B. Eckenhoff, Felix A. Landrau, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
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Patent number: 6287295Abstract: Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system.Type: GrantFiled: July 24, 1998Date of Patent: September 11, 2001Assignee: Alza CorporationInventors: Guohua Chen, Scott D. Lautenbach, Keith E. Dionne, Scott D. Jordan, Steve A. Berry, Craig I. Rodenberger, Rupal Ayer
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Patent number: 6283953Abstract: Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.Type: GrantFiled: December 22, 1998Date of Patent: September 4, 2001Assignee: ALZA CorporationInventors: Rupal Ayer, James B. Eckenhoff, Stephen A. Berry, Gregory R. Stewart, Scott D. Jordan
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Patent number: 6270787Abstract: An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery device includes an implant capsule containing a beneficial agent and an osmotic agent. Holes are formed along a side wall of the implant capsule at an open end of the capsule. When the membrane plug is inserted into the open end of the capsule the membrane material swells into the holes in the capsule side wall creating a large frictional force which prevents expulsion of the membrane plug. A beneficial agent delivery rate of the osmotic delivery system is controllable by varying the size and number of the holes to change the amount of exposed surface area of the membrane plug. An increase in the surface area of the membrane plug exposed to the exterior environment causes a corresponding increase in the liquid permeation rate of the membrane and thus, increases the beneficial agent delivery rate.Type: GrantFiled: December 22, 1998Date of Patent: August 7, 2001Assignee: ALZA CorporationInventor: Rupal Ayer
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Patent number: 6264990Abstract: This invention relates to stable non-aqueous formulations which are suspensions of proteinaceous substances or nucleic acids in non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity. More specifically, the present invention relates to stable protein or nucleic acid formulations wherein the compound remains in stable, dry powder form, yet the formulation is flowable and, therefore amenable to delivery to an animal via injection, transdermal administration, oral delivery or using an implantable device for sustained delivery. These stable formulations may be stored at elevated temperatures (e.g., 37° C.) for long periods of time and are especially useful as flowable formulations which can be shipped and/or stored at high temperatures or in implantable delivery devices for long term delivery (e.g., 1-12 months or longer) of drug.Type: GrantFiled: December 14, 1999Date of Patent: July 24, 2001Assignee: ALZA CorporationInventors: Victoria Marie Knepp, Steven Joseph Prestrelski, Jessica G. Smith, Manley T. Huang
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Patent number: 6235712Abstract: This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: February 28, 2000Date of Patent: May 22, 2001Assignee: ALZA CorporationInventors: Cynthia L. Stevenson, Steven J. Prestrelski
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Patent number: 6217906Abstract: A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed.Type: GrantFiled: September 17, 1999Date of Patent: April 17, 2001Assignee: ALZA CorporationInventors: Juan C. Gumucio, Keith E. Dionne, James E. Brown
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Patent number: 6190350Abstract: An implanter for inserting subcutaneous implants includes a handle for grasping the implanter during implantation, a hollow cannula receiving the implant, and a rod for releasing the implant from the cannula. The rod is longitudinally fixed within the handle while the cannula slides over the rod to release the implant. The cannula is moved over the rod by a sliding actuator mounted in a track of the handle. The actuator is locked in an extended position to prevent unintended release of the implant. Preferably, the implanter is a single-use device having a actuator locking feature preventing reuse.Type: GrantFiled: December 22, 1998Date of Patent: February 20, 2001Assignee: Alza CorporationInventors: Craig R. Davis, John R. Peery
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Patent number: 6180129Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.Type: GrantFiled: October 23, 1997Date of Patent: January 30, 2001Assignee: Alza CorporationInventors: Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
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Patent number: 6156331Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.Type: GrantFiled: May 12, 1999Date of Patent: December 5, 2000Assignee: ALZA CorporationInventors: John R. Peery, Keith E. Dionne, James B. Eckenhoff, deceased, Felix A. Landrau, Scott D. Lautenbach, Judy A Magruder, Jeremy C. Wright
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Patent number: 6124261Abstract: This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: April 19, 1999Date of Patent: September 26, 2000Assignee: ALZA CorporationInventors: Cynthia L. Stevenson, Steven J. Prestrelski
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Patent number: 6113938Abstract: An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.Type: GrantFiled: July 24, 1998Date of Patent: September 5, 2000Assignee: ALZA CorporationInventors: Guohua Chen, Scott Lautenbach, Keith Dionne, Lawton Hom
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Patent number: 6068850Abstract: This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: February 11, 1999Date of Patent: May 30, 2000Assignee: Alza CorporationInventors: Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, deceased, Jeremy C. Wright, John J. Leonard, Jr.
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Patent number: 6066619Abstract: This invention relates to stable non-aqueous protic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous protic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: April 16, 1999Date of Patent: May 23, 2000Assignee: Alza CorporationInventors: Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, Jeremy C. Wright, John J. Leonard, Jr.
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Patent number: 5997902Abstract: The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall.Type: GrantFiled: August 3, 1998Date of Patent: December 7, 1999Assignee: Alza CorporationInventors: Frederick H. Maruyama, Judy A. Magruder
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Patent number: 5980509Abstract: A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. The wall may further comprise an end cap which may be adapted for ultrasonic welding to the first wall section and may maintain the beneficial agent in contact with an exit. The compartment comprises a beneficial agent and an expandable driving member. The delivery system comprises an exit for delivering the beneficial agent to the animal.Type: GrantFiled: November 24, 1997Date of Patent: November 9, 1999Assignee: Alza CorporationInventors: Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann
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Patent number: 5972370Abstract: The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight beneficial agent and having a viscosity and beneficial agent size which minimizes settling of the agent in suspension over the extended delivery period.Type: GrantFiled: January 28, 1999Date of Patent: October 26, 1999Assignee: Alza CorporationInventors: James B. Eckenhoff, deceased, Leslie A. Holladay, John Joseph Leonard, Jr., Iris K. M. Leung, Sally A. Tao, Judy A. Magruder, John P. Carr, Jeremy C. Wright
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Patent number: 5842476Abstract: An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.Type: GrantFiled: May 9, 1995Date of Patent: December 1, 1998Assignee: ALZA CorporationInventors: Jeri Dawn Wright, Jerry D. Childers, Brian L. Barclay, Patrick S.-L. Wong, Linda E. Atkinson
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Patent number: 5840074Abstract: The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery device provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent.Type: GrantFiled: June 2, 1992Date of Patent: November 24, 1998Assignee: ALZA CorporationInventors: Atul Devdatt Ayer, James B. Eckenhoff, Jeremy C. Wright, Anthony L. Kuczynski
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Patent number: 5785994Abstract: A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.Type: GrantFiled: April 1, 1992Date of Patent: July 28, 1998Assignee: ALZA CorporationInventors: Patrick S.-L. Wong, Felix Theeuwes, Atul Devdatt Ayer, Anthony L. Kuczynski