Abstract: In one embodiment the present invention provides a coated substrate comprising a substrate, a radiation-cured coating or a thermally-cured on at least a portion of the substrate, wherein the coating comprises an inherent macroscopic texture. In another embodiment, the present invention provides a pre-cured coating mixture comprising a radiation-curable resin and an initiator, or a thermally-curable resin and thermal initiator, wherein the radiation- or thermally-curable resin and the respective initiator form a pre-cured coating mixture capable of forming a macroscopic texture upon application of the mixture on a substrate. In another embodiment the present invention provides a pre-cured coating mixture comprising a radiation- or thermally-curable resin, an initiator, and texture-producing particles having an effective size to provide a macroscopic texture upon application of the mixture on a substrate.

Abstract: This invention relates to a method for the analysis of a (at least one) target non-proteinaceous component of a mixture of non-proteinaceous and proteinaceous components derived from a biological sample using a protease from a Bacillus strain. The invention further relates to a method for the analysis of a (at least one) target nucleic acid component of a mixture of non-proteinaceous components, which comprise nucleic acids, and proteinaceous components whereby the mixture is derived from a biological sample comprising the steps of incubating the mixture with a (at least one) protease from a Bacillus strain, optionally amplifying the (at least one) target nucleic acid component, and determining or detecting the (at least one) target nucleic acid component.

Abstract: Apparatus is described for capacitively signalling between different semiconductor chips and modules without the use of connectors, solder bumps, wire-bond interconnections or the like. Preferably, pairs of half-capacitor plates, one half located on each chip, module or substrate are used to capacitively couple signals from one chip, module or substrate to another. The use of plates relaxes the need for high precision alignment as well as reduces the area needed to effect signalling, and reduces or eliminates the requirements for exotic metallurgy.

Abstract: A computerized method of presenting information from a variety of sources on a display device. Specifically the present invention describes a graphical user interface for organizing the simultaneous display of information from a multitude of information sources. In particular, the present invention comprises a graphical user interface which organizes content from a variety of information sources into a grid of tiles, each of which can refresh its content independently of the others. The grid functionality manages the refresh rates of the multiple information sources. The present invention is intended to operate in a platform independent manner.

Abstract: This invention comprises methods for making nanostructured and nanoporous thin film structures of various compositions. These films can be directly patterned. In these methods, precursor films are deposited on a surface and different components of the precursor film are reacted under selected conditions, forming a nanostructured or nanoporous film. Such films can be used in a variety of applications, for example, low k dielectrics, sensors, catalysts, conductors or magnetic films. Nanostructured films can be created: (1) using one precursor component and two reactions, (2) using two or more components based on differential rates of photochemical conversion, (3) using two precursors based on the thermal sensitivity of one precursor and the photochemical sensitivity of the other, and (4) by photochemical reaction of a precursor film and selected removal of a largely unreacted component from the film.

Abstract: The present invention relates to a novel gene, CaSm, that is highly expressed in cancer tissues and cell lines, especially pancreatic cancer. The full length cDNA of CaSm encodes a protein of 133 amino acids. CaSm contains the two Sm motifs found in the common snRNP proteins, with the greatest homology to the Sm G protein (60% similarity). The present invention further encompasses CaSm peptides, fusion proteins, host cell expression systems, antibodies to CaSm, antisense CaSM molecules, and compounds that modulate CaSm gene expression or CaSm activity. Antisense CaSm RNA is able to alter the transformed phenotype of pancreatic cancer cells by reducing their ability to form large colonies in soft agar when compared to untransfected cells. The present invention also encompasses methods for disease diagnosis, drug screening and the treatment of cancer.

Abstract: The present invention is directed to a process for obtaining a substrate provided with a coating having photocatalytic properties, wherein the coating includes crystallized particles of an oxide of a metal A having photocatalytic properties. The crystallized particles are incorporated into the coating using a mineral binder comprising at least one oxide of a metal B also having photocatalytic properties in the crystallized state. The coating optionally includes at least oxide of a metal M devoid of photocatalytic properties and/or at least one silicon compound of the silicon oxide SiO2 type. The coating is deposited from liquid-phase dispersions containing the crystallized particles of the oxide of metal A and at least one precursor compound for the oxide of metal B of the binder and optionally a precursor compound for the oxide of metal M and for the Si compound, in a relative proportion A/(B+M+Si) by weight of the metals and Si ranging between 60/40 and 40/60.

Abstract: Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.

Abstract: The present invention relates to novel butyne diol derivatives of the general formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula I and especially their use as endothelin receptor antagonists.

Abstract: The present invention relates to a system for delivering and injecting an agent into a target site within the body without penetrating the tissue of the target site with anything other than the agent. The system comprises a nozzle assembly and a propulsion mechanism. The nozzle assembly comprises an ampule with a reservoir, having a reservoir orifice, for containing the agent; a dispersion fixture that has a dispersion orifice; and a channel in fluid communication between the reservoir orifice and the dispersion orifice. The propulsion mechanism is operatively coupled to the reservoir for propelling the agent from within the reservoir, through the reservoir orifice and the channel and the dispersion orifice, at a pressure sufficient to cause the agent to penetrate the target site without penetration of the target site with the dispersion fixture. Methods of using and making the system are also disclosed.

Abstract: The present invention relates to (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing a disorder alleviated by inhibiting dopamine reuptake. In one embodiment, the disorder is attention-deficit disorder, depression, obesity, Parkinson's disease, a tic disorder, or an addictive disorder. The (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof is preferably substantially free of its corresponding (+)-enantiomer.

Abstract: A chuck assembly for use in semiconductor processing equipment includes elements that permit reticle expansion and assembly misalignment without additional reticle deformation. Reticle expansion is allowed by flexible support elements that are positioned to move in the direction of expansion, but that also combine to provide the control necessary for processing. Misalignment is allowed by connections that attach the reticle securely and uniquely to the support elements despite some amount of imperfection in the reticle, or the connections themselves. Accounting in this way for expansion and misalignment prevents additional reticle distortion and thus improves the accuracy of the product.

Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Abstract: The present invention relates to a new and distinct cultivar of blackberry plant named ‘Driscoll Sonoma’. The new cultivar is distinguished from other blackberry cultivars by its fruit of excellent fruit flavor and shipping quality. ‘Driscoll Sonoma’ is a thornless mid-late season cultivar. The new cultivar is distinguished from its seed parent by its larger fruit and greater plant vigor. The new cultivar is distinguished from its pollen parent by its larger, better flavored fruit.

Abstract: The present invention relates to a new and distinct cultivar of raspberry plant named Driscoll Carmelina. The new cultivar is distinguished from other raspberry cultivars by its late primocane production, high spring yields, good flavor and disease resistance. The new cultivar is distinguished from its seed parent by having better release from the receptacle, firmer fruit and better spring bud break. The new cultivar is distinguished from its pollen parent by producing firmer fruit with better shipping characteristics.

Abstract: The present invention relates to a new and distinct cultivar of blackberry plant named Driscoll Eureka. The new cultivar is distinguished from other blackberry cultivars by its early season, low chill requirement and improved quality and shipping characteristics. The new cultivar is distinguished from its seed parent by being early and having better flavored fruit, it is distinguished from its pollen parent by its better flavor.

Abstract: This invention relates to a new and distinct variety of strawberry named ‘Driscoll Camarillo’. The variety is similar to the varieties ‘Baeza’ and ‘Ventura’. The variety is distinguished from ‘Baeza’ and ‘Ventura’ in that ‘Driscoll Camarillo’ has a longer fruiting truss, a dark green coloration of the upper side of the leaf, a globosely plant habit, even fruit coloration, and absent to small hollow center size.