Patents Represented by Law Firm Pennie & Edmonds
  • Patent number: 6676679
    Abstract: Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: January 13, 2004
    Assignee: Boston Scientific Corporation
    Inventors: Richard L. Mueller, U. Hiram Chee
  • Patent number: 6677130
    Abstract: Compositions and methods are provided for the treatment of diseases associated with mitogen activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the p38-2 kinase cascade. Such polypeptides and agents may also be used for the treatment of diseases associated with mitogen-activated protein kinase cascades.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 13, 2004
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Bernd Stein, Maria X. H. Yang, David B. Young
  • Patent number: 6677269
    Abstract: Solid polymeric onium poly(hydrogen fluoride) complexes disclosed herein can be used for alkylating aliphatic or aromatic hydrocarbons with olefins. These solid polymeric complexes can be formed by a process of contacting a source of hydrogen fluoride with a homopolymer or copolymer containing in at least one repeat unit, a nitrogen, phosphorus, or sulfur atom, capable of forming an onium fluoride moiety upon reaction or complexation with the hydrogen fluoride source.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: January 13, 2004
    Inventor: George A Olah
  • Patent number: 6676931
    Abstract: Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprises formulation I: polar solvent 37-98.58%, active compound 0.005-55%, optionally containing flavoring agent 0.1-10%.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: January 13, 2004
    Assignee: NovaDel Pharma Inc.
    Inventor: Harry A. Dugger, III.
  • Patent number: 6676308
    Abstract: Disclosed is a traffic accident photographing device for a vehicle. The device comprises camera-fastening means for fastening a camera to the vehicle to allow the camera to photograph an actual scene upon occurrence of a collision; and shutter-pressing means for allowing a shutter of the camera fastened to the vehicle by the camera-fastening means, to be pressed by a weight member which is moved under action of inertia force generated by the collision.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: January 13, 2004
    Inventor: Kyung-Il Baek
  • Patent number: 6676977
    Abstract: Compositions and methods for reducing or eliminating the appearance of cellulite. The method involves administering to a patient in need of treatment therapeutically effective amounts of a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin, a primary antioxidant component in an amount sufficient to substantially inhibit the formation of collagenase and elastase, at least one amino acid component in an amount sufficient to assist in the thickening of the skin, and at least one transition metal component in an amount effective to bind collagen and elastic fibers and thicken skin so as to reduce or eliminate the appearance of cellulite. A preferred method of treatment further includes administering the components above in conjunction with a vascular dilator to improve blood supply to the skin and/or a fat burner to reduce absorption or digestion of fat in the digestive tract or to prevent the production of fat.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: January 13, 2004
    Inventor: Howard Murad
  • Patent number: 6678366
    Abstract: A system and method for locating the subscriber of a telephony product in which a best guess location is assigned to each subscriber of the telephony product. Under certain predetermined conditions, the telephony product directs incoming phone calls to a subscriber by first attempting to locate the subscriber at the best guess location. If the best guess location does not successfully answer or is not attempted first, an alternate search method is used.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: January 13, 2004
    Assignee: Ulysses ESD, Inc.
    Inventors: Eric William Burger, John Kimball, Walter Joseph O'Connor, Nancy Margaret Taylor, Sanjiv Parikh, Christina Pax
  • Patent number: 6676927
    Abstract: The present invention relates to non-human animals and in vivo methods for testing the efficacy of antibodies directed to antigens expressed by tumors in such animals. In particular, the invention relates to an animal deficient in the expression of one or more Fc receptors. Additionally, such an animal is also immunodeficient, and thus permits the growth of a xenogeneic tumor implant. Such immunodeficient animals may also express human receptors. The present invention also relates to methods of evaluating the enhanced ability of an existing antibody or Fc-modified antibody to act as an immunotherapeutic to eradicate tumor cells or infectious agents.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: January 13, 2004
    Assignee: The Rockefeller University
    Inventor: Jeffrey V. Ravetch
  • Patent number: 6672825
    Abstract: A method of increasing the power generated by a steam turbine includes the step of receiving, at a steam turbine final stage, a steam byproduct with an electrically charged component. An electric field is created immediately proximate to the steam turbine final stage to substantially eliminate the electrically charged component from the steam byproduct and thereby reduce turbulence associated with the steam byproduct.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: January 6, 2004
    Assignee: Electric Power Research Institute, Inc.
    Inventors: Anatoly O. Tarelin, Volodymyr P. Skliarov
  • Patent number: 6673374
    Abstract: This application relates to a pharmaceutical composition and methods for treating inflammatory skin conditions. The compositions include hydrogen peroxide, one or more moisturizing agents, and an anti-inflammatory agent. The pharmaceutical compositions may optionally include one or more exfoliants. The compositions can be used to treat inflammatory skin conditions such as dermatitis, including, but not limited to seborrheic dermatitis, nummular dermatitis, contact dermatitis, atopic dermatitis, exfoliative dermatitis, perioral dermatitis, and stasis dermatitis; psoriasis; folliculitis; rosacea; acne; impetigo; erysipelas; paronychia, erythrasma; and eczema.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: January 6, 2004
    Inventor: Howard Murad
  • Patent number: 6674543
    Abstract: A printer with a housing arranged to be manually positioned on an image receiving medium. In order to allow easy alignment, a window is provided such that the print face is visible through the window. A controller of the printer is operable to detect markings on an image receiving medium, the markings being scanned by means of a scanner. An indicator referring to a direction in which the printer is to be moved and the detected markings are displayed in order to obtain alignment between the print face and the detected markings. The printer uses a medium with alignment marks, or alternately prints alignment marks onto a medium. Finally, a base station with an adjustable stop for positioning a print medium is included.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: January 6, 2004
    Assignee: Esselte N.V.
    Inventors: Robert Charles Lewis Day, Jonathan Kemp, Adrian Michael Woodward, Lawrence Archard, Robert Charles Sims, Geert Heyse, Michel Woodman, Chris McCleve, Martin Gibbs
  • Patent number: 6674512
    Abstract: An interferometer measuring system comprising two moveable members and a reference member that may have significantly less movement, the group having a number of attached measurement mirrors, interferometers for measuring position and two optical support blocks for the interferometers. The interferometers are used to determine the measured optical path lengths to each of the moveable members and reference member and these positions are used to calculate the misalignment, or error in the relative positions of the moveable members with respect to the reference member. This calculated error is then used to correct the misalignment by moving the appropriate members in the manner directed by the calculation.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: January 6, 2004
    Assignee: Nikon Corporation
    Inventors: W. Thomas Novak, David Stumbo, Fuyuhiko Inoue
  • Patent number: 6675084
    Abstract: A transmission control system for controlling a transmission is provided with a shift lever whose position is changeable through a lever-shifting action by a driver selecting a transmission stage to be changed into, a transmission stage detection unit for detecting a new position of the shift lever due to the lever-shifting action, and outputting corresponding signals, and a transmission control unit receiving the signals from the transmission stage detection unit and performing a gear-shifting operation of the transmission, the transmission control unit having therein a time map being of a number of values of permissible time intervals that respectively correspond to all kinds of gear-shifting operations of the transmission, the transmission control unit allowing the currently performed gear-shifting operation to be held only during a corresponding permissible time interval set in the time map in a case that it receives another transmission shift request while the gear-shifting operation is currently being p
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: January 6, 2004
    Assignee: Hyundai Motor Company
    Inventor: Joung-Chul Kim
  • Patent number: 6673828
    Abstract: The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: January 6, 2004
    Assignee: Children's Medical Center Corporation
    Inventors: Shawn J. Green, Glenn M. Swartz, Jr., Jamshed H. Shah, John Madsen, Adonia E. Papathanassiu, William Fogler
  • Patent number: 6672196
    Abstract: A spade assembly for use on an artillery vehicle compensates any gaps which would otherwise be formed between a ground supporting portion of the spade assembly and the soil. The length of the spade assembly is advantageously compensated to maintain the spade assembly in firm contact with the soil. This can increase the accuracy in the weapon in firing, and avoid violent displacement of the gun which can be caused when the spade assembly is not maintained firmly engaged with the earth.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: January 6, 2004
    Assignee: Ordinance Development and Engineering Company of Singapore (1996) Pte Ltd.
    Inventor: Teoh Hwa Ang
  • Patent number: 6673536
    Abstract: The present invention provides methods and systems, particularly computer systems, for determining the relative specificity with which a particular polynucleotide molecule hybridizes to a polynucleotide probe. For example, the methods and systems of the invention enable a user to compare the specificity with which different polynucleotides hybridize to a given probe and/or rank these polynucleotides according to their specificity to that probe. The methods and systems of the invention also enable a user to compare the specificity with which a particular polynucleotide hybridizes to different probes, and/or rank those different probes according to their specificity for that particular polynucleotide.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: January 6, 2004
    Assignee: Rosetta Inpharmatics LLC.
    Inventors: Roland Stoughton, Julja Burchard, Stephen H. Friend
  • Patent number: 6672603
    Abstract: The present invention provides a suspension layout using a steering gear frame, in which a steering apparatus assembly and a sub-frame are combined in a single structure. The sub-frame includes a plurality of side members, which are provided along the longitudinal direction of the vehicle frame and at a predetermined distance from each other. A cross member extends in the direction of the width of the vehicle and fixedly connects the side members. The steering apparatus assembly includes steering gear motors that are provided for each side member and cooperate through steering transmitting assemblies to rotate steering knuckles.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: January 6, 2004
    Assignee: Hyundai Motor Company
    Inventor: Unkoo Lee
  • Patent number: 6673741
    Abstract: A guard catalyst, comprising an alumina support and molybdenum and/or tungsten and nickel and/or cobalt supported on the alumina support, wherein the total ammonia integral adsorption heat of said alumina support does not exceed 25 J/g, the percentage taken up by the ammonia integral adsorption heat of the ammonia differential adsorption heat greater than 100 kJ/mol does not exceed 10% of the total ammonia integral adsorption heat. Compared to the catalysts of the prior art, the guard catalyst has higher catalytic activity, less coke deposit, lower reduction rate of pore volume, better stability of activity, and higher strength.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: January 6, 2004
    Assignees: China Petroleum and Chemical Corporation, Research Institute of Petroleum Processing, SINOPEC
    Inventors: Xiaohong Kang, Kui Wang, Weizheng Dong, Qinghe Yang, Li Zhu
  • Patent number: 6673234
    Abstract: A combined process of low degree solvent deasphalting and delayed coking, which comprises feeding a deasphalting stock and a solvent into an extractor and making the yield of the deasphalted oil 70 wt %-95 wt %, and introducing a part or all of the deasphalted oil and optionally a conventional coking stock into a delayed coker. This process increases the yield of liquid products, removes the heavy asphaltene which is prone to coke, extends the run length of the delayed coker, and at the same time, lowers the content of impurities in coke, enlarges the sources of the stocks for producing the needle coke.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: January 6, 2004
    Assignees: China Petroleum and Chemical Corporation, Research Institute of Petroleum Processing, Sinopec
    Inventors: Rui Li, Zijun Wang, Jun Long
  • Patent number: D485308
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: January 13, 2004
    Assignee: BIC Corp.
    Inventors: Donald A. DeLuca, Michael Kent, John N. Mitra