Patents Represented by Attorney, Agent or Law Firm Peter S. Dardi, Ph.D.
  • Calcification-resistant biomaterials
    Patent number: 6302909
    Abstract: The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than about 0.5 mg metal cations per gram of biocompatible material. The calcification inhibitors preferably decrease calcium deposition by greater than 95% relative to untreated tissue. The calcification inhibitors are bonded to the bioprosthetic material preferably at a pH between about 6.0 and 8.5.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: October 16, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Matthew F. Ogle, Richard F. Schroeder
  • Medical article with adhered antimicrobial metal
    Patent number: 6267782
    Abstract: A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: July 31, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Matthew F. Ogle, William R. Holmberg, Richard F. Schroeder, Donald S. Guzik, M. William Mirsch, II, Darrin J. Bergman, Hallie A. Finucane, Katherine S. Tweden
  • Efficient production of particles by chemical reaction
    Patent number: 6248216
    Abstract: A method for efficiently producing particles from gas phase chemical reactions induced by a radiation beam. The apparatus includes a reaction chamber and an elongated reactant inlet, where the reaction chamber is configured to conform generally to the elongated shape of the reactant inlet. Shielding gas may be introduced to form a blanket of inert gas on both sides of the reactant stream. A feed back loop may be used to maintain the desired pressure within the reaction chamber.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: June 19, 2001
    Assignee: Nanogram Corporation
    Inventors: Xiangxin Bi, Nobuyuki Kambe