Patents Represented by Attorney, Agent or Law Firm Philip E. Hansen
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Patent number: 6784187Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.Type: GrantFiled: November 26, 2002Date of Patent: August 31, 2004Assignee: Rensselaer Polytechnic Inst.Inventor: Mark P. Wentland
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Patent number: 6503391Abstract: The device comprises filtration means and pumping means each housed in a compact unit mounted with the panels of a swimming pool basin. The unit includes a compartment (A) housing the filtration means in communication with the water of the basin, and a compartment (B) out of the water which contains the pumping means. The unit includes in the filtration compartment an assembly having first and second 90° elbows for intaking water from the basin. One of the elbows has arrangements for coupling to the bottom of the member containing the filtration means, while the other elbow has arrangements for coupling with a straight element. The unit also includes in the pumping compartment third and fourth 90° elbows for the intake of water. One of the third and fourth elbows is coupled to a straight element, and the other elbow of the third and fourth elbows is connected to a delivery side of the pumping means. Also included in the pumping compartment are fourth and fifth elbows for delivering water to the basin.Type: GrantFiled: November 1, 2001Date of Patent: January 7, 2003Assignee: Piscines Desjoyaux S.A.Inventors: Jean Louis Desjoyaux, Pierre Louis Desjoyaux, Catherine Jandros
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Patent number: 6478917Abstract: This invention relates to a process for manufacturing a ski, or like board for gliding over snow, which comprises, on the surface, embedded elements constituted by elements of additional protecting and decorative layers, these elements being flush with the surface of the ski. According to the invention, the protecting and decorative sheet is laid flat, before being placed in the mould, and the thin elements to be embedded are added thereon by bonding. The assembly of the ski elements is then moulded conventionally, with the result that the inner, uniformly smooth surface of the lid of the mould presses on the additional elements and consequently embeds them in the protecting and decorative sheet.Type: GrantFiled: July 14, 1999Date of Patent: November 12, 2002Inventors: Fabrice Magoni, Henri-Charles Deborde
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Patent number: 6474571Abstract: A mechanism for the treatment of materials by pressurized water jets includes a body (1) for supplying water under pressure which includes a feeding chamber (2) extending over the whole length of the body, and wherein water under pressure is fed to the feeding chamber through a filter (4). The body also includes a distributing zone for distributing water under pressure over a whole treatment length against a plate (7) provided with micro-perforations which define water needles (8) directed against the surface (S) of the material to be treated. The material is supported by a carriage element subjected to a suction source eliminating the treatment water.Type: GrantFiled: November 28, 2001Date of Patent: November 5, 2002Assignee: Rieter PerfojetInventors: Laurent Schmit, Bruno Roche
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Patent number: 6472563Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.Type: GrantFiled: November 9, 2001Date of Patent: October 29, 2002Assignee: Sepracor Inc.Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W Kessler
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Patent number: 5401675Abstract: A process for sputter deposition wherein high aspect ratio apertures are coated with conductive films exhibiting low bulk resistivity, low impurity concentrations, and regular morphologies. A collimator is used having an aspect ratio that approximates the aspect ratio of the apertures.Type: GrantFiled: March 24, 1993Date of Patent: March 28, 1995Inventors: Pei-Ing P. Lee, Thomas J. Licata, Thomas L. McDevitt, Paul C. Parries, Scott L. Pennington, James G. Ryan, David C. Strippe
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Patent number: 5335091Abstract: An apparatus for imparting a controlled relative displacement of two parallel surfaces along a single axis or along two orthogonal axes is disclosed. Controlled displacement along any axes, orthogonal or otherwise, may be obtained by stacking appropriately oriented single-axis units. The apparatus uses a force-generating means and connecting beams acting in concert to produce a relative displacement of two rigid parallel frames. An imaging means is mounted on one rigid frame and a photosensitive matrix on the other to provide an electro-optical detector system in which the image field may be periodically displaced along a closed trajectory to cover the interstices between the detector elements of the photosensitive matrix. A method for the use of the apparatus to generate electronic picture information is also disclosed.Type: GrantFiled: December 31, 1991Date of Patent: August 2, 1994Assignee: Eastman Kodak CompanyInventor: Russell J. Palum
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Patent number: 5268372Abstract: Novel 2,5-benzodiazocines of formulas II and IV, pharmaceutical compositions containing them, processes for preparing them and methods of treating cardiac arrhythmias in mammals utilizing them.Type: GrantFiled: February 17, 1993Date of Patent: December 7, 1993Assignee: Sterling Winthrop Inc.Inventor: Robert E. Johnson
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Patent number: 5141931Abstract: 6-Alkyl-5-(6, or 7-quinolinyl)-3-(substituted)-2(1H)-pyridinones useful as cardiotonics are synthesized by reaction of trialkylquinolinylstannanes with 6-alky-5-halo-3-(substituted)-2(1H)-pyridinones. Compositions containing these pyridinones and methods of using them to treat congestive heart failure are provided.Type: GrantFiled: January 3, 1991Date of Patent: August 25, 1992Assignee: Sterling Winthrop Inc.Inventor: Edward R. Bacon
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Patent number: 5099012Abstract: Conjugates of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with p-aminophenylsaccharides, with aminoalkyl-derivatized dextrans and with polylysines and polyornithines are prepared by condensation using diimides. Methods and compositions for the use of such conjugates to protect mammals from reperfusion injury are also disclosed.Type: GrantFiled: December 11, 1990Date of Patent: March 24, 1992Assignee: Eastman Kodak CompanyInventors: Tai-Wing Wu, Donald A. G. Mickle
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Patent number: 5091410Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.Type: GrantFiled: June 10, 1991Date of Patent: February 25, 1992Assignee: Sterling Winthrop Inc.Inventors: Theodore C. Miller, Michael E. Ross
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Patent number: 5080886Abstract: The combination of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid with a superoxide dismutase optionally containing a catalase and ascorbic acid provides enhanced protection from oxidant injury.Administration of 6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid, SOD, and optionally CAT and/or ascorbic acid prior to or simultaneously with resuming normal blood supply to mammalian tissue following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion. Administration of Vitamin E, SOD, and CAT similarly provide protection from oxidant injury.Type: GrantFiled: January 5, 1990Date of Patent: January 14, 1992Assignee: Sterling Drug Inc.Inventors: Donald A. G. Mickle, Tai-Wing Wu
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Patent number: 5047258Abstract: A process for spray-coating tablets and the like utilizing only an acrylate enteric polymer and plasticizer in water is disclosed. The process can be practiced on a commercial scale and requires no antiadherent in the coating formulation. The process comprises providing inlet air having a dew point below about 10.degree. C. and a temperature between 35.degree. and 60.degree. C.Type: GrantFiled: December 4, 1990Date of Patent: September 10, 1991Assignee: Sterling Drug Inc.Inventors: Raymond J. Belanger, Gregg Stetsko, Shrikant N. Pagay
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Patent number: 5010086Abstract: 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.Type: GrantFiled: August 7, 1990Date of Patent: April 23, 1991Assignee: Sterling Drug Inc.Inventors: George Y. Lesher, deceased, Edward R. Bacon, Baldev Singh, Gee-Hong Kuo
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Patent number: 4988725Abstract: N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.Type: GrantFiled: December 28, 1989Date of Patent: January 29, 1991Assignee: Sterling Drug Inc.Inventors: Denis M. Bailey, Ronald G. Powles
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Patent number: 4970081Abstract: An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.Type: GrantFiled: January 3, 1989Date of Patent: November 13, 1990Assignee: Sterling Drug Inc.Inventor: Steven E. Frisbee
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Patent number: 4963561Abstract: Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula ##STR1## where R.sub.1 and R.sub.3 are hydrogen or lower-alkyl, R.sub.5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4- or 3-pyridinyl, or phenyl or substituted phenyl.Type: GrantFiled: February 28, 1990Date of Patent: October 16, 1990Assignee: Sterling Drug Inc.Inventors: George Y. Lesher, Edward R. Bacon, Baldev Singh, Gee-Hong Kuo
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Patent number: 4962120Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-imidazole-1-acetamides useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of a diaryl imidazole-1-acetic acid with an appropriate diamine.Type: GrantFiled: March 22, 1989Date of Patent: October 9, 1990Assignee: Sterling Drug Inc.Inventors: Denis M. Bailey, Virendra Kumar
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Patent number: 4925857Abstract: N-[(alkylamino)alkyl]-4,5-diaryl-1H-pyrazole-1-acetamides, wherein at least one of the aryl substituents is a pyridine, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine.Type: GrantFiled: March 22, 1989Date of Patent: May 15, 1990Assignee: Sterling Drug Inc.Inventors: Denis M. Bailey, Thomas E. D'Ambra, Alan M. Ezrin
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Patent number: 4916150Abstract: N-[alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.Type: GrantFiled: March 22, 1989Date of Patent: April 10, 1990Assignee: Sterling Drug Inc.Inventors: Denis M. Bailey, Ronald G. Powles