Abstract: A method for cross-linking biological tissue is provided which uses as a cross-linking agent a low molecular weight, substantially monomeric polyfunctional aldehyde formed in situ or just prior to cross-linking. The polyfunctional aldehyde is essentially free of the undesirable heterogeneous polymeric species that result from polyfunctional aldehyde self-reactivity. Also provided is biological tissue that is cross-linked with a substantially monomeric glutaraldehyde.
Type:
Grant
Filed:
April 9, 1999
Date of Patent:
January 23, 2001
Assignee:
Sulzer Carbomedics Inc.
Inventors:
Chandrashekhar P. Pathak, Mark A. Moore, Richard E. Philips, Jr.