Abstract: Novel methods and compositions are provided for preventing secondary cataracts. A cytotoxic agent is employed which is introduced into the anterior chamber of the eye to inhibit proliferation of remnant tens epithelial cells after extracapsular cataract extraction. Desirably a non-cytotoxic agent crossreactive with the cytotoxic agent is introduced prior to introduction of the cytotoxic agent. The agents can be provided as kits.