Abstract: The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particularly useful in vaginal, buccal and ocular devices.

Abstract: A non-invasive detection method for glucose and other constituents of interest in a sample is described. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing the spectrophotometers used in other non-invasive near infrared detection methods. A plurality of detection units are used, each covering a broad region of the detected spectrum, paralleling color perception and colorimetry. In some circumstances, a neural net is used for analysis, allowing the system to learn. Analyte concentrations in scattering mediums can be obtained by calibrating the results with in vitro measurements.

Abstract: The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.

Abstract: The invention provides a system for recording and displaying a time sequential scene on a computer (16). The digital camera (12) transmits a sequence of digital image frames to the timer (14) representative of the image of a body passing a plane in space. Each frame represents a line object (18) of the body, thus forming a fractional part of the scene. Once the frame reaches the image timer (14), it is digitally marked with a time reference (34) and buffered into a block of information. The main control computer (16) stores blocks of information from the image timer (14) for a variety of processing and features available to the user. The invention also provides a selected memory (36), preferably a virtual memory subsystem, or hard-disc drive. Preferred constructions for adjusting camera pixel processing of light values, time-marking the images, creating color palettes for interactive viewing of color images, and video data coding to accommodate the high volume of line image data are described.

Abstract: Ophthalmic compositions and methods of using the same to simultaneously treat eye surface inflammation and dry eye are disclosed. The ophthalmic preparation contains a tetracycline compound in aqueous solution. The preparation preferably further includes a balance of electrolytes sufficient to maintain or restore essentially normal levels of conjunctival mucus-containing goblet cells and corneal glycogen. These electrolytes can include potassium, chloride, bicarbonate, sodium, calcium, magnesium and phosphate.

Abstract: A helical tooling process for economical production of high quality, high temperature thermoplastic composite tubes uses a mandrel or external cylinder to resist a force applied from a helical member for consolidation pressure, compaction, and part removal. The helical too long process facilitates the prescription of a desired consolidation pressure and diameter, independent of temperature. The advantages of the disclosed process include improved produced part quality, increased process flexibility, and enhanced economic efficiency. These advantages stem from the device being easily controlled and fabricated and having a low thermal mass.

Abstract: Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the toxicity of pyrimidine nucleoside analogues during the treatment of retroviral diseases, such as AIDS, and that uridine phophorylase inhibitors are particularly effective in maintaining the necessary levels of uridine within such cells. A treatment for AIDS-type diseases is disclosed in which a pyrimidine nucleoside analogue and a uridine phosphorylase inhibitor are co-administered either simultaneously or sequentially to treat the viral infections and protect or rescue uninfected cells in the afflicted subject. This combination therapy also can be supplemented by direct administration of uridine.

Abstract: A new method of forming composites or laminates into complex shapes has been developed. A process using a die with piercing studs allows control of fibers motion during processing, leading to better composite parts.