Abstract: Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II:
Ar1—W—Ar2—X—Q II
The compounds of the invention are structurally different from NSAIDs and opiates, and are antagonists of the pain and inflammatory effects of E-type prostaglandins.
Type:
Grant
Filed:
October 4, 1999
Date of Patent:
April 3, 2001
Assignee:
Merck Frosst Canada & Co.
Inventors:
Michel Belley, Marc Labelle, Nicholas Lachance, Michel Gallant, Nathalie Chauret, Laird A. Trimble, Chun Li