Abstract: A medication delivery device comprising a system that is able to sense if the delivery device is in actual physical contact with a human being or if the delivery device has been abandoned. The system comprises an electronic control and a touch sensitive switch preferably formed as a part of the housing of the medication delivery device. The housing can be divided into two parts each constituting separate electrical conductors being spaced apart from each other by an insulating material. When the two parts a temporarily bridged e.g. by the skin of a human being a direct current path between the parts are created, which can provide an electrical signal at the electronic control. When a dose has been set, absence of the signal will cause the electronic control to cancel the set dose and to sound an alarm.

Abstract: The present invention relates to halo sulfonyl aryl boronates of the general formula (I): wherein Arylene designates a carbocyclic or heterocyclic, aromatic ring system comprising 1-3 rings; R1, R2 and R3 are, independently, hydrogen, C1-6alkyl, C1-6alkoxy, halogen, nitro, cyano or phenyl; X is fluoro, chloro or bromo; and Y is a boroxine moiety attached via a bond from Arylene to one of the boron atoms of a boroxine ring which ring has a group of the formula -Arylene(R1)(R2)(R3)SO2X, wherein Arylene, R1, R2, R3 and X are as defined above, at each of the other two boron atoms of the boroxine ring, or Y is a boronic acid group or a boronic ester group. The invention also relates to the preparation of the compounds of formula (I) and to their use in organic synthesis.

Abstract: The present invention relates to protracted human insulin derivatives in which the A21 and the B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; PheB1 may be deleted; the B30 amino acid residue is (a) a non-codable, lipophilic amino acid having from 10 to 24 carbon atoms, in which case an acyl group of a carboxylic acid with up to 5 carbon atoms is bound to the ?-amino group of LysB29; or (b) the B30 amino acid residue is deleted or is any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys, in any of which cases the ?-amino group of LysB29 has a lipophilic substituent; and any Zn2+ complexes thereof with the proviso that when B30 is Thr or Ala and A21 and B3 are both Asn, and PheB1 is present, then the insulin derivative is always present as a Zn2+ complex.

Abstract: A solid composition containing a meiosis activating substance can be prepared by adding a protein or a phosperglycid.

Abstract: Disclosed is a method of preparing zinc free rapid acting insulin analogue. In one embodiment insulin crystals are prepared by providing a solution of an analogue having a pH between 7 and 9.5. The solution is mixed with a salt of an alkali metal or salt and formed crystals are recovered.

Abstract: A dose setting device for a delivery system has a piston rod (6, 9) which successively presses a piston (2) into a cylinder ampoule (1). Doses are set by rotating a second part (9) of the piston rod (6, 9) in relation to a first part (6). The two parts are connected by mating threads so that the total length of the piston rod (6, 9) is increased proportional to the angle of rotation, and a point (18) on the second part is moved away from a stop position fixed in relation to a housing (5) The set dose is delivered when the point (18) is moved back to the stop position. The first part (6) can be axially displaced but not rotated in the housing (5), and the second part (9) can both rotate and be axially displaced. The first part (6) is maintained in abutment with the piston (2) and the second part (9) is coupled to be rotated by a dose setting wheel (20).

Abstract: An apparatus for filling a cartridge with a liquid comprises, a platform on which the cartridge is supported and which can be lifted relative to a stationary filling needle (5) so that this filling needle is moved into the cartridge (6), a pump (1) feeding liquid through the filling needle (5) into the cartridge (6), a sensor head (10) from which a beam of light is sent from one side of the cartridge to the other along a path immediately over an upper edge of the cartridge (6), and a reflector (11) reflecting the light beam back to the sensor head (10), which is connected to a sensor box (12) which produces a signal stopping the pump (1) and causing the needle (5) to be drawn out of the cartridge (6) when this cartridge is full and the liquid forms a droplet over the opening of the cartridge, which droplet deflects the light beam.

Abstract: A linear actuator comprising a first member (1) and a second member (2) provided with internal threads (6,8) cut in opposite directions and an intermediary member (3) engaged with and being axially displaceable in relation to the first and second members (1,2), via external threads (11,12) that are complementary to the threads (6,8) provided on the first and second members (1,2). The linear actuator furthermore comprises a sheath (4) stretching across the intermediary member (3), which sheath (4) is inrotatably, but longitudinally slidably arranged in relation to the first and second members (1,2). The linear actuator also comprises a driving rod (5) that is inrotatably, but longitudinally slidably arranged within the intermediary member (3). A medical delivery device provided with such a linear actuator is also provided.

Abstract: Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.

Abstract: The present invention relates to a transfer device for transferring medicament from a medicament container to a syringe with a needle. The transfer device is arranged for transferring accurate dosages of insulin, growth hormone or other medicaments. The accuracy is ensured by the device comprising means for mounting a syringe to the device, the needle piercing a sealing of the device. Opposite the sealing a piston is arranged, said piston being non-releasable engaged with the piston driver during transfer of the medicament. Thereby the piston is not erroneously drawn from the piston driver, which would otherwise lead to incorrect dosing. Furthermore, the device comprises dosing means including the piston driver.

Abstract: Described is an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampule when the injection button is actuated. When working in the injection mode, a dose set by operation of the dose setting means is injected by operation of the injection button. The electronic injection device is normally working in the air shot mode but shifts to work in the dose injection mode when it receives a signal indicating that the dose setting means has been operated. The circuit returns to its air shot mode when receiving a signal indicating that the set dose has been injected. This signal can originate either from a switch indicating that the protection cap is mounted or from a switch indicating that the injection button has been pressed.

Abstract: An injection device for injecting set doses from an ampoule (2) mounted in the device, which doses are set by operation of a dose setting button (7) by which operation elastic torsion rods (14) positioned parallel with the longitudinal axis of the device are twisted. By the dose setting a torque is transmitted from the dose setting button (7) to the rods (14) through gear transmissions comprising a toothing (11) carried by a tubular (8) part coupled to the dose setting button (7) to rotate with this button. The toothing (11) engages pinions (13) fixed to the proximal ends of the torsion rods (14), which are made from a super elastic material, which can stand a deformation larger than 2% without being permanently deformed.

Abstract: Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.

Abstract: An injection device made up from a housing, a dose setting and injection mechanism, a dose setting member and an injection button is described. The dose setting and injection mechanism is made as a preassembled unit insertable into the housing. Both the dose setting member and the injection button is thereafter connected to the preassembled dose setting and injection mechanism inside the boundaries of the housing, while being accessible for a user from outside the housing. The same preassembled dose setting and injection mechanism can fit into a large variety of different houses making production of different variants of an injection device somewhat easier.

Abstract: A medicament container for storing a liquid medicament, such as insulin, comprises a wall with at least two opposite portions made of a polymer material having a light transmission at 400 nm of at least 25%, a glass transition temperature above 50° C., and a density of 0.95 g/cm3 or more. The polymer material comprises at least 70% by weight of a copolymer material composed of aliphatic cyclic or bicyclic hydrocarbons with 5 to 7 membered ring or rings and ethylene or propylene. The container is substantially inert to the medicament and, because it is either transparent or at least includes at least two opposed transparent portions, it is possible visually to inspect the contents of the container to make sure that the medicament has not crystalized or polymerized. The walls of the container provide a good barrier against m-cresol/phenol/benzyl alcohol preservatives and water.

Abstract: The present invention discloses a regimen for the treatment of type 2 diabetes, in which the endogenous secretion of insulin is stimulated in connection with meals, by administering a short-acting, oral hypoglycemic agent. Also, the present invention discloses a method of achieving improvement in glycemic control by combined use of repaglinide and metformin in NIDDM patients poorly controlled on metformin alone.

Abstract: Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

Abstract: An injection device for injection of set does of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting drum. An injection button is coupled to the piston rod with a gear wheel transmission. Axial movement of the injection button causes a corresponding axial movement of the piston rod until the nut engages an abutment in the housing.

Abstract: The present invention relates to a method and a system for producing an elongated drug formulation being suitable for being injected through the skin of a patient with-out the use of a needle or a cannula. The drug formulation is produced by compressing a drug granulate in cavity of a system comprising a roller and a surface, wherein the roller roles over the surface thereby comprising the granulate to the formulation.

Abstract: A method of self treating a disease, such as diabetes, includes collecting in one or more databases data representing values of parameters that related to the self treatment. The data is processed to provide a plurality of alternate choices between two or more actions that may be taken and a corresponding value for each action is calculated. A computerized system may be employed to perform the above method and the system may include a computer readable medium for executing the method.