Patents Represented by Attorney, Agent or Law Firm Rezo Green, Esq.
  • Glucagon antagonists/inverse agonists
    Patent number: 6503949
    Abstract: Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: January 7, 2003
    Assignee: Noro Nordisk A/S
    Inventors: Jesper Lau, Peter Madsen, Christian Sams, Carsten Behrens, Josef Vagner, Inge Thøger Christensen, Behrend Frederik Lundt, Ulla Grove Sidelmann, Henning Thøgersen, Anthony L. Ling, Michael Bruno Plewe, Larry Kenneth Truesdale, Shenghua Shi
  • Method of acylating peptides and novel acylating agents
    Patent number: 6451974
    Abstract: Provided is a method for acylating one or more amino groups of a peptide or protein such as GLP-1. This method includes (a) reacting a peptide or protein having at least one free amino group with an acylating agent of formula I wherein n is 0-8; R1 is COOR4; R2 is a lipophilic moiety; R3 and its attached carboxyl group designate a reactive ester or a reactive N-hydroxy imide ester; and R4 is selected from hydrogen, C1-12-alkyl and benzyl, under basic conditions in a mixture of an aprotic polar solvent and water; and (b) if R4 is not hydrogen, saponifying the acylated peptide or protein ester group under basic conditions in order to obtain an N-acylated peptide or an N-acylated protein.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: September 17, 2002
    Assignee: Novo Nordisk A/S
    Inventor: Louis Brammer Hansen