Patents Represented by Attorney, Agent or Law Firm Richard A. Hake
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Patent number: 5663189Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein (a) n is an integer from 1 to about 3;(b) X and Y are each independently selected from O, S and CH.sub.2, with at least one of X and Y being O or S;(c) R is unsubstituted, straight or branched chain alkanyl or alkanoxy having from 1 to about 3 non-hydrogen atoms; and(d) R' is selected from hydrogen, methyl, cyano, and halo; pharmaceutical compositions containing such compounds; and the use of such compounds for preventing or treating one or more of respiratory disorders, ocular disorders, and gastrointestinal disorders.Type: GrantFiled: June 7, 1995Date of Patent: September 2, 1997Assignee: The Procter & Gamble CompanyInventors: Peter Julian Maurer, Jeffrey Joseph Ares, William Lee Seibel, Daniel P. Walker
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Patent number: 5648346Abstract: A substantially flat collapsed plastic bag with an evacuation form unit insert positioned therein as manufactured to serve as a form about which the filled bag will collapse as it is emptied. The form unit comprises a ring for mounting the unit on the spout of the bag and a multi-channel form extending radially from the ring and hingedly connected thereto. A simple method is provided for manufacturing the bag with the form unit insert.Type: GrantFiled: June 7, 1995Date of Patent: July 15, 1997Assignee: The Procter & Gamble CompanyInventors: Ronald Eugene White, Thomas Prosser Demuth, Jr.
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Patent number: 5646139Abstract: Compounds of Structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzable esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: The Procter & Gamble CompanyInventors: Ronald Eugene White, Thomas Prosser Demuth, Jr.
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Patent number: 5646163Abstract: The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): ##STR1## wherein (1) R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and(2)(a) R.sup.4 and R.sup.5 are, independently, hydrogen; lower alkyl; cycloalkyl; heteroalkyl; or --C(.dbd.O)--X--R.sup.8, where X is a covalent bond, N, O, or S, and R.sup.8 is lower alkyl, lower alkenyl, arylalkyl, a carbocylic ring, or a heterocyclic ring; or(b) R.sup.4 and R.sup.5 together comprise a heterocyclic ring that includes the nitrogen to which they are bonded;and the pharmaceutically-acceptable salts, biohydrolyzable esters, biohydrolyzable amides, and solvates thereof.Type: GrantFiled: April 28, 1994Date of Patent: July 8, 1997Assignee: The Procter & Gamble CompanyInventors: Thomas Prosser Demuth, Jr., Ronald Eugene White
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Patent number: 5639746Abstract: The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula I ##STR1## wherein (A)R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently selected from various substituents; and(B) where R.sup.3 and R.sup.4 or R.sup.4 and R.sup.5 may together comprise a cyclic moiety; or a pharmaceutically-acceptable salt, biohydrolyzable amide or biohydrolyzable ester thereof.In other aspects, the invention is directed to pharmaceutical compositions containing the compounds of Formula (I), and to methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.Type: GrantFiled: December 29, 1994Date of Patent: June 17, 1997Assignee: The Procter & Gamble CompanyInventor: Kenneth Edward Yelm
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Patent number: 5637580Abstract: Compounds of structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzables esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.Type: GrantFiled: June 7, 1995Date of Patent: June 10, 1997Assignee: The Procter & Gamble CompanyInventors: Ronald E. White, Thomas P. Demuth, Jr.
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Patent number: 5631256Abstract: Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.3, R.sup.4, and R.sup.6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and(2) (1) R.sup.1 is X, R.sup.3 is X, or both R.sup.1 and R.sup.3 are X; and X is the thiourea containing moietyand pharmaceutically-acceptable salts and biohydrolyzable esters thereof, and hydrates thereof.Type: GrantFiled: April 8, 1994Date of Patent: May 20, 1997Assignee: The Procter & Gamble CompanyInventors: Thomas P. Demuth, Jr., Ronald E. White
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Patent number: 5602227Abstract: The present invention relates to biodegradable PHA copolymers comprising at least two randomly repeating monomer units. The present invention further relates to a plastic article comprising a biodegradable copolymer, wherein the biodegradable copolymer comprises at least two randomly repeating monomer units (RRMU) wherein the first RRMU has the structure ##STR1## wherein R.sup.1 is H, or C.sub.1 or C.sub.2 alkyl, and n is 1 or 2; the second RRMU has the structure ##STR2## wherein R.sup.2 is a C.sub.4 -C.sub.19 alkyl or alkenyl; and wherein at least 50% of the RRMUs have the structure of the first RRMU. The present invention further relates to an absorbent article comprising a liquid pervious topsheet, a liquid impervious backsheet comprising a film comprising a PHA of the present invention and an absorbent core positioned between the topsheet and the backsheet.Type: GrantFiled: August 30, 1995Date of Patent: February 11, 1997Assignee: The Procter & Gamble CompanyInventor: Isao Noda
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Patent number: 5591836Abstract: Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation to the diet, or incorporated into food compositions.Type: GrantFiled: October 7, 1993Date of Patent: January 7, 1997Assignee: The Procter & Gamble CompanyInventors: Adam W. Mazur, Stanislaw Pikul, Bruce P. Daggy
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Patent number: 5578607Abstract: The subject invention relates to compounds having the structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl;(b) R' is selected from unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; and halo; and(c) R" is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; methyl monosubstituted with hydroxy, thiol or amino; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; amino; unsubstituted amide; unsubstituted or C.sub.1 -C.sub.3 substituted amido; halo; unsubstituted sulfoxide; unsubstituted sulfonyl; and cyano;pharmaceutical compositions containing such compounds, and the use of such compounds for preventing or treating respiratory, ocular, and/or gastrointestinal disorders.Type: GrantFiled: October 20, 1994Date of Patent: November 26, 1996Assignee: The Procter & Gamble CompanyInventors: Thomas L. Cupps, Peter J. Maurer, Jeffrey J. Ares
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Patent number: 5576437Abstract: The subject invention involves methods of treating nasal congestion comprising administration, to a human or lower animal in need of such treatment of a safe and effective amount of a compound having the following structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; and(b) R' is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo.The subject invention also involves the use of such compounds for preventing or treating other respiratory, ocular and/or gastrointestinal disorders. The subject invention also involves novel compounds having the above structure wherein R' is hydrogen or fluoro or cyano.Type: GrantFiled: August 18, 1994Date of Patent: November 19, 1996Assignee: The Procter & Gamble CompanyInventors: Thomas L. Cupps, Sophie E. Bogdan
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Patent number: 5552420Abstract: Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl, oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl;Y is an alkylene bridge of 3-9 carbon atoms;R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or substituted phenyl or substituted heterocyclyl is an effective antipicornaviral agents.Type: GrantFiled: May 13, 1994Date of Patent: September 3, 1996Assignee: Sterling Winthrop Inc.Inventors: David J. Aldous, Thomas R. Bailey, Guy D. Diana, Theodore J. Nitz, Gee-Hong Kuo
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Patent number: 5541187Abstract: Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclyl-carboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.Type: GrantFiled: November 30, 1993Date of Patent: July 30, 1996Assignee: Sterling Winthrop Inc.Inventors: Edward R. Bacon, Baldev Singh, George Y. Lesher, deceased
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Patent number: 5541210Abstract: The subject invention involves compounds having the following structure: ##STR1## wherein: (a) R is unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl;(b) R' is selected from hydrogen; unsubstituted C.sub.1 -C.sub.3 alkanyl or alkenyl; unsubstituted C.sub.1 -C.sub.3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo; and(c) R' is selected from hydrogen, methyl, ethyl and i-propyl.The subject invention also involves pharmaceutical compositions containing such novel compounds, compositions thereof and the use of such compounds for preventing or treating respiratory, ocular and/or gastrointestinal disorders.Type: GrantFiled: June 29, 1995Date of Patent: July 30, 1996Assignee: The Procter & Gamble CompanyInventors: Thomas L. Cupps, Sophie E. Bogdan
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Patent number: 5536564Abstract: The present invention relates to biodegradable PHA copolymers comprising at least two randomly repeating monomer units (RRMU) wherein the first RRMU has the structure ##STR1## wherein R.sup.1 is H or C.sub.2 alkyl, and n is 1 or 2; the second RRMU has the structure ##STR2## ; and wherein at least 50% of the RRMUs have the structure of the first RRMU. The present invention further relates to plastic articles comprising said biodegradable PHA copolymers. The present invention further relates to an absorbent article comprising a liquid pervious topsheet, a liquid impervious backsheet comprising a film comprising a PHA of the present invention and an absorbent core positioned between the topsheet and the backsheet.Type: GrantFiled: June 6, 1995Date of Patent: July 16, 1996Assignee: The Procter & Gamble CompanyInventor: Isao Noda
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Patent number: 5530116Abstract: Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A.sup.1, A.sup.2, A.sup.3, R.sup.1, and R.sup.4 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and(2) R.sup.6 is part of a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula: ##STR2## wherein (3) R.sup.10, R.sup.11, R.sup.12, R.sup.13, and R.sup.Type: GrantFiled: December 22, 1994Date of Patent: June 25, 1996Assignee: The Procter & Gamble CompanyInventors: Thomas P. Demuth, Jr., Ronald E. White
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Patent number: 5523312Abstract: Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1## wherein Het.sub.1 is chosen from the group consisting of oxazolyl, isoxazolyl, oxadiazolyl;Y is an alkylene bridge of 3 to 9 carbon atoms;Het.sub.2 is benzofuranyl or indolyl;R.sub.1 and R.sub.2 are each independently chosen from hydrogen, halo, acetyl, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluromethyl, or cyano; andR.sub.3 is oxazolyl, oxadiazolyl, isoxazolyl or any of these substituted with alkyl, halo, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl, or fluoroalkyl;the N-oxide thereof or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: September 27, 1994Date of Patent: June 4, 1996Assignee: Sterling Winthrop Inc.Inventors: David J. Aldous, Thomas R. Bailey, Guy D. Diana, Gee-Hong Kuo, Theodore J. Nitz, Michael Reuman
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Patent number: 5521223Abstract: The subject invention relates to methods for regulating wrinkles in mammalian skin comprising topical application of a lysophosphatidic acid compound having the structure: ##STR1## or a cyclic derivative thereof having the structure: ##STR2## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 12 to about 23 carbon atoms; each --X-- is independently --O-- or --S--; and --Y-- is --O-- or --CH.sub.2 --.Type: GrantFiled: May 13, 1993Date of Patent: May 28, 1996Assignee: The Procter & Gamble CompanyInventors: Gary A. Piazza, Adam W. Mazur
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Patent number: 5514679Abstract: Compounds of the formula ##STR1## wherein: R.sub.1 and R.sub.2 are independently hydrogen, halo, alkyl, alkenyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, alkylthioalkynyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy or cyanomethyl, nitro, difluoromethyl, trifluoromethyl or cyano;Y is alkylene of 3 to 9 carbon atoms;R.sub.3 and R.sub.4 are independently hydrogen, alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkanoyl, alkanoyloxy, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, cyanomethyl, fluoroalkyl, cyano, phenyl, alkynyl, alkene, or halo;R.sub.5 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle;or a pharmaceutically acceptable acid addition salts thereof; N-oxides thereof, are useful as antipirconaviral agents.Type: GrantFiled: May 13, 1994Date of Patent: May 7, 1996Assignee: Sterling Winthrop Inc.Inventors: David J. Aldous, Thomas R. Bailey, Guy D. Diana, Theodore J. Nitz
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Patent number: 5492894Abstract: The present invention relates to topical compositions comprising a peptide having the formulaQ.sup.a -(Xaa).sub.n -Q.sup.cwherein Q.sup.a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q.sup.c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino; n is an integer selected from the group consisting of 3, 4, 5 and 6; Xaa is independently any amino acid; and at least three of the amino acids are selected from the group consisting of arginine and lysine.Type: GrantFiled: June 25, 1993Date of Patent: February 20, 1996Assignee: The Procter & Gamble CompanyInventors: Charles C. Bascom, Andrew W. Fulmer