Patents Represented by Attorney Richard P. Fish & Richardson Burgoon, Jr.

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  • Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
    Patent number: 5536639
    Abstract: The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
    Type: Grant
    Filed: March 25, 1994
    Date of Patent: July 16, 1996
    Assignee: Cephalon, Inc.
    Inventors: Robert Siman, Donna Bozyczko-Coyne
  • Use of indolocarbazole derivatives to treat a pathological condition of the prostate
    Patent number: 5516771
    Abstract: The invention features a method of treating a pathological condition of the prostate gland, e.g., benign prostatic hypertrophy or prostate cancer, in a mammal, said method comprising administering to said mammal a therapeutic amount of the indolocarbazole compound K-252a or a preferred derivative thereof. The invention also includes novel derivatives of K-252a.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: May 14, 1996
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Craig A. Dionne, Patricia C. Contreras, Chikara Murakata
  • K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
    Patent number: 5468872
    Abstract: Functional K-252a derivatives are used to enhance trk phosphorylation and to potentiate the activity of neurotrophin-3 (NT-3). These compounds can be used to treat neurological disorders, alone or in combination with NT-3.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: November 21, 1995
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Marcie A. Glicksman, David P. Rotella, Nicola Neff, Chikara Murakata