Patents Represented by Attorney Richard W. Bork, Esq.
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Patent number: 6953812Abstract: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity.Type: GrantFiled: February 24, 2003Date of Patent: October 11, 2005Assignee: Novo Nordisk, Inc.Inventors: Anker Steen Jorgensen, Inge Thoger Christensen, Janos Tibor Kodra, Christian Sams, Carsten Behrens, Peter Madsen, Jesper Lau
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Patent number: 6939853Abstract: Methods and uses for treatment of dyslipidemia comprising administration of a GLP-1 compound and another antidyslipidemic drug.Type: GrantFiled: December 23, 2002Date of Patent: September 6, 2005Assignee: Novo Nordisk A/SInventors: Lotte Bjerre Knudsen, Johan Selmer
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Patent number: 6894023Abstract: A process for producing cation crystals of growth hormone or growth hormone derivatives, as well as growth hormone and growth hormone derivatives. The process of producing the growth hormone crystals includes the steps of (a) adding cations of inorganic or organic nature and an organic solvent or a mixture of inorganic solvents at a pH between 5.0 and 6.8 to a solution of growth hormone or derivatives. (b) growing growth hormone crystals at a temperature from about 0 to 30° C. and (c) isolating the cation crystals.Type: GrantFiled: June 12, 2000Date of Patent: May 17, 2005Assignee: Novo Nordisk A/SInventors: Flemming Junker, Claus Friis Theisen
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Patent number: 6818738Abstract: Disclosed is a method of preparing zinc free rapid acting insulin analogue. In one embodiment insulin crystals are prepared by providing a solution of an analogue having a pH between 7 and 9.5. The solution is mixed with a salt of an alkali metal or salt and formed crystals are recovered.Type: GrantFiled: May 20, 2002Date of Patent: November 16, 2004Assignee: Novo Nordisk A/SInventor: Svend Havelund
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Patent number: 6777207Abstract: Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.Type: GrantFiled: June 28, 2001Date of Patent: August 17, 2004Assignee: Novo Nordisk A/SInventors: Thomas Børglum Kjeldsen, Svend Ludvigsen
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Patent number: 6726661Abstract: Described is an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampule when the injection button is actuated. When working in the injection mode, a dose set by operation of the dose setting means is injected by operation of the injection button. The electronic injection device is normally working in the air shot mode but shifts to work in the dose injection mode when it receives a signal indicating that the dose setting means has been operated. The circuit returns to its air shot mode when receiving a signal indicating that the set dose has been injected. This signal can originate either from a switch indicating that the protection cap is mounted or from a switch indicating that the injection button has been pressed.Type: GrantFiled: December 10, 2002Date of Patent: April 27, 2004Assignee: Novo Nordisk A/SInventors: Jens Munk, Denmark Denmark Aasmul, Henrik Ljunggreen, Lars Hofmann Christensen
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Patent number: 6692472Abstract: An injection device made up from a housing, a dose setting and injection mechanism, a dose setting member and an injection button is described. The dose setting and injection mechanism is made as a preassembled unit insertable into the housing. Both the dose setting member and the injection button is thereafter connected to the preassembled dose setting and injection mechanism inside the boundaries of the housing, while being accessible for a user from outside the housing. The same preassembled dose setting and injection mechanism can fit into a large variety of different houses making production of different variants of an injection device somewhat easier.Type: GrantFiled: May 1, 2001Date of Patent: February 17, 2004Assignee: Novo Nordisk A/SInventors: Steffen Hansen, Thomas Dedenroth Miller
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Patent number: 6660197Abstract: The present invention relates to a method and a system for producing an elongated drug formulation being suitable for being injected through the skin of a patient with-out the use of a needle or a cannula. The drug formulation is produced by compressing a drug granulate in cavity of a system comprising a roller and a surface, wherein the roller roles over the surface thereby comprising the granulate to the formulation.Type: GrantFiled: October 12, 2000Date of Patent: December 9, 2003Assignee: Novo Nordisk A/SInventors: Thomas Buch-Rasmussen, Søren Aasmul, James M. Flink, Philip Hansen, Claus Juul-Mortensen, Jens-Ulrik Poulsen
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Patent number: 6649641Abstract: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.Type: GrantFiled: November 16, 2001Date of Patent: November 18, 2003Assignee: Novo Nordisk A/SInventors: Carsten Behrens, Jesper Lau, Peter Madsen
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Patent number: 6639515Abstract: A method for clinical surveillance of a treatment group and an other group involves defining an adverse event, possible a serious adverse event, noting each occurrence of the adverse events, and, starting at zero, calculating a cumulative sum of the adverse events by updating the cumulative sum each time a further adverse event is reported and, when the adverse event is in the treatment group, adding 1 to the cumulative sum, and, when the adverse event is in the other group, adding 0 to the cumulative sum. This invention also involves subtracting a chosen quantity K from the cumulative sum, comparing the cumulative sum to a predetermined alarm limit, determining when the cumulative sum reaches at least the predetermined alarm limit, and indicating the predetermined alarm limit has been reached.Type: GrantFiled: October 11, 2001Date of Patent: October 28, 2003Assignee: Novo Nordisk A/SInventor: Philip Hougaard
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Patent number: 6620780Abstract: The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.Type: GrantFiled: May 21, 2001Date of Patent: September 16, 2003Assignee: Novo Nordisk A/SInventors: Jan Markussen, Ib Jonassen, Svend Havelund, Jakob Brandt, Peter Kurtzhals, Per Hertz Hansen, Niels Christian Kaarsholm
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Patent number: 6620112Abstract: A disposable lancet combined with a reagent carrying strip which carries a reagent that indicates the concentration of a blood component in a blood sample placed in contact with the strip. The reagent carrying strip is connected to the lancet, e.g. by molding. One end of the lancet is sharpened for piercing the skin. The strip is sheet-like and has a first side and a second side, which sides are both accessible for the user, such that the reagent carrying strip can be inserted into a blood glucose meter. A weakened tear line is provided at a connection between the lancet and an edge of the reagent carrying strip so that the reagent carrying strip may be easily disconnected from the lancet.Type: GrantFiled: March 14, 2001Date of Patent: September 16, 2003Assignee: Novo Nordisk A/SInventor: Lars Peter Klitmose
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Patent number: 6590072Abstract: The present invention relates to a method for extractive refolding of scrambled and/or polymerised single-chain polypeptides or proteins into their native conformation directly from a microbial fermentation broth.Type: GrantFiled: January 23, 2001Date of Patent: July 8, 2003Assignee: NNA/SInventor: Ivan Diers
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Patent number: 6586574Abstract: The invention relates to the use of glycylglycine, optionally in combination with a sugar, and/or a sugar alcohol, and/or an amino acid, as a bulking agent in freeze-drying.Type: GrantFiled: August 15, 2000Date of Patent: July 1, 2003Assignee: NN A/SInventor: Lars Lindgaard Hansen
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Patent number: 6585699Abstract: A drug delivery device comprising a housing (1) with a drug container (2) being provided with delivering means comprising a piston (5) for expelling a drug (4) from the drug container (2). The housing (1) further comprising a displaceable piston rod (6) abutting the piston (5) of the drug container (2) and rotating means being in engagement with the piston rod (6), said rotating means being provided with a one-way mechanism. The one-way mechanism comprises a helical spring (12) wound tightly around an axle (11), one end of said helical spring (12) being fixed in relation to the housing (1), the other end of the helical spring (12) being in a free state.Type: GrantFiled: March 30, 2001Date of Patent: July 1, 2003Assignee: NNA/SInventors: Henrik Ljunggreen, Jens Ulrik Poulsen, Soren Aasmul, Lars Hofmann Christensen, Jens Moller-Jensen, Peter Moller-Jensen
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Patent number: 6585982Abstract: In vitro fertilization can be improved by adding a meiosis activating compound.Type: GrantFiled: March 20, 2000Date of Patent: July 1, 2003Assignee: NNA/SInventors: Christian Grøndahl, Thomas Høst Hansen, Alexander Rübig, Christa Hegele-Hartung
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Patent number: 6582408Abstract: The present invention relates to a medication delivery device comprising a cartridge assembly, a dosing assembly and optionally a needle assembly. The cartridge assembly comprises a cartridge having a stopper adapted to receive a plunger. Furthermore, the cartridge assembly has one end sealed with a pierce able sealing, said end comprising coupling device for engaging a needle assembly, and another end comprising coupling device for engaging the dosing assembly. The dosing assembly comprises a plunger and has coupling device for engaging the cartridge assembly. The cartridge assembly and the dosing assembly are coupled together for delivering selected doses of medication. The device further comprises mechanism for securing that the plunger abuts on the stopper during use of the device, in particular when the dosing assembly is releasable coupled to the cartridge assembly.Type: GrantFiled: July 8, 1999Date of Patent: June 24, 2003Inventors: Thomas Buch-Rasmussen, Benny Munk, Jens Ulrik Poulsen, Henrik Ljungreen, Peter Møller Jensen, Jens Møller Jensen
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Patent number: 6569832Abstract: This invention relates to a method for modulating, inhibiting or decreasing or preventing beta cell degeneration, loss of beta cell function, beta cell dysfunction, and/or death of beta cells, such as necrosis or apoptosis of beta cells in a subject comprising administering a GLP-1 agonist to said subject.Type: GrantFiled: November 10, 2000Date of Patent: May 27, 2003Assignee: Novo Nordisk A/SInventors: Liselotte Bjerre Knudsen, Carsten Foged Godtfredsen, Jacob Sten Petersen, Richard David Carr, Søren Bregenholt
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Patent number: 6569126Abstract: By a cylinder ampoule (1), comprising a tubular vessel with a membrane (4) sealingly closing one end and a piston (9) closing the other end, liquid stored between said piston (9) and said membrane (4) can be pressed out through an injection needle (7) piercing the membrane (4) when the piston (9) is pressed into the ampoule (1). The tube is made from a plastically deformable material. A pressure foot (10) on which a piston rod (13) is acting abuts the piston (9), carries a spring plate (11) made from a harder material than is the ampoule (1), is mainly perpendicular to the ampoule (1) axis, and has at least one diameter which is larger than the inner diameter of the ampoule (1) so that edges of the plate (11) abutting the inner wall of the ampoule (1) are deflected away from the piston (9) to form an acute angle with said wall.Type: GrantFiled: July 8, 1998Date of Patent: May 27, 2003Assignee: Novo Nordisk A/SInventors: Jens Ulrik Poulsen, Jens Møller-Jensen
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Patent number: 6566329Abstract: A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an amorphous hGH isoprecipitate, the slurry having a pH of from about 4.7 to 5.0 and being essentially free of buffer components other than acetate.Type: GrantFiled: June 14, 2000Date of Patent: May 20, 2003Assignee: Novo Nordisk A/SInventors: Giorgio Meyn, Hans Holmegaard Sørensen, Thorkild Christensen