Abstract: A process for preparing (4S,5R)-5-carboxymethyl-2,2-dimethyl-4-phenyl-oxazolidine-3-carboxylic acid t-butyl ester, an intermediate in the preparation of anticancer compounds having a taxane skeleton, such as paclitaxel, docetaxol, etc.
Type:
Grant
Filed:
November 18, 2005
Date of Patent:
December 25, 2012
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
Siripragada Mahender Rao, Ramanatham Josyula, C. Naveen Kumar Reddy, Veerababu Kagita, Yusuf Vohra
Abstract: Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride.
Type:
Grant
Filed:
December 19, 2008
Date of Patent:
November 15, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.,
Abstract: Substantially non-porous polymeric microparticles comprising a hydrophobic polymer and a plasticizer, and containing therein a bioactive or bioinactive agent.
Type:
Grant
Filed:
June 5, 2006
Date of Patent:
November 8, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.,
Abstract: Voriconazole is prepared by a process comprising condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to give (2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-diflurophenyl)-1-(1H -1,2,4-triazole-1-yl)butan-2-ol.
Type:
Grant
Filed:
June 10, 2010
Date of Patent:
October 18, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
Type:
Grant
Filed:
January 5, 2009
Date of Patent:
September 7, 2010
Assignees:
Dr. Reddy's Laboratories, Inc., Dr. Reddy's Laboratories Limited
Abstract: A process for preparation of crystalline Form I of clopidogrel hydrogen sulphate, that include separating the crystalline Form I of clopidogrel hydrogen sulphate from a solution of clopidogrel freebase in a solvent, which is 2-propanol or 2-butanol is provided.
Type:
Grant
Filed:
March 11, 2005
Date of Patent:
August 10, 2010
Assignees:
Dr. Reddy's Laboratories, Inc., Dr. Reddy's Laboratories Limited
Abstract: The present invention is related to novel polymorph of Fexofenadine and Fexofenadine hydrochloride of formula 1 and process of preparation thereof. The present invention is also directed to provide pure novel polymorphs of Fexofenadine and its hydrochloride by a simple process which is cost effective, commercially viable and environment friendly.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
April 20, 2010
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
M. Satyanarayana Reddy, S. Thirumalai Rajan, U. V. Bhaskara Rao
Abstract: A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided.
Type:
Grant
Filed:
August 28, 2003
Date of Patent:
November 3, 2009
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: A process for making amino acid amides, comprising reacting an amino acid, or acid salt of an amino acid, with a halogenating agent, or with a substance that reacts with carboxylic acids to form a leaving group, to form an intermediate, then reacting the intermediate with ammonia. When the amino acid or acid salt is enantiomerically pure, the amide will be a stereoisomer. An amide made by the process can be used to form levetiracetam.
Type:
Grant
Filed:
February 16, 2005
Date of Patent:
May 12, 2009
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
Palle V. R. Acharyulu, C. M. Haricharan Raju
Abstract: The present invention relates to a novel polymorphic form of 17-?-(N-ter.butyl carbamoyl)-4-aza-5-?-androst-1-en-3-one (Finasteride) of the Formula (I) and processes for preparing the form.
Type:
Grant
Filed:
March 15, 2004
Date of Patent:
March 10, 2009
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
M. Satyanarayana Reddy, S. T. Rajan, M. V. N. Brahmeshwara Rao, K. Vyas, S. Vishnuvardhana Reddy, K. Shashi Rekha
Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
Type:
Grant
Filed:
December 4, 2003
Date of Patent:
February 10, 2009
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride.
Type:
Grant
Filed:
September 5, 2006
Date of Patent:
January 13, 2009
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: A new crystalline Form III of moxifloxacin monohydrochloride and processes for making the crystalline form as well as compositions, pharmaceutical compositions, and methods utilizing the crystalline form are described.
Type:
Grant
Filed:
April 9, 2004
Date of Patent:
June 12, 2007
Assignees:
Reddy's Laboratories Limited, Reddy's Laboratories, Inc.
Inventors:
Manne Satyanarayana Reddy, Sajja Eswaraiah, Vetukuri Venkata Naga Kali Vara Prasada Raju, Rapolu Rajesh Kumar, Ningam Srinivasreddy, Vedantham Ravindra