Abstract: Stabilized and activated Factor VIII is used as a therapeutic agent to treat patients with a Factor VIII deficiency. This includes hemophilia A patients as well as patients with Factor VIII inhibitors which block the hemostatic activity of Factor VIII. The stabilized and activated Factor VIII is also prepared in a therapeutic composition with a therapeutically acceptable adjuvant.

Abstract: Bis(salicyl) diesters useful as cross-linking agents for hemoglobin are prepared in high yield and purity by reacting salicylic acid or a derivative thereof with a lower aliphatic dicarboxylic acid halide in a lower aliphatic ketone or nitrile solvent in the presence of a pyridine derivative. The desired diester is recovered from the resulting insoluble pyridine derivative salt.

Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.

Abstract: An improved method of synthesizing 3,5-dibromosalicylic acid provides a highly purified pharmaceutical grade product free of toxic by-products and solvents. The purified product may be utilized as an intermediate in synthesizing pharmaceutical grade substances, as a bactericide when incorporated into topical ointments, and as an adjuvant in drug absorption systems.

Abstract: An external introducer for a ventricular catheter that is part of a hydrocephalus shunt system. The introducer includes a stylet assembly that mates with a cannula assembly. The cannula assembly comprises a cannula having a bent tip and an opening on the sidewall of the cannula, and a cannula hub into which a catheter is clipped. The stylet assembly includes a flexible stylet attached to a stylet hub. When the stylet hub is locked to the cannula hub, the stylet protrudes slightly from the end of the cannula at an angle. The introducer holds the catheter approximately straight for insertion into the ventricle of the brain.

Abstract: Nutritional compositions for management of hepatic failure are improved by eliminating certain ammonotelic amino acids and reducing the proportion of essential ammonotelic amino acids. A composition is provided which is optimized for nutritional therapy and suppression of hyperammonemia.

Abstract: A shunt system for implantation in the body comprises a body having an inlet and an outlet and a first fluid-flow passageway extending between the inlet and outlet. A pressure regulated valve is provided within the first fluid-flow passageway to provide fluid flow at selected fluid pressures in the passageway. A filter is positioned within the first fluid-flow passageway. A second fluid-flow passageway extends between the inlet and outlet and provides a passageway through the body around the filter. A valve and valve seat is provided within the second fluid-flow passageway which can be selectively closed or opened to provide fluid flow through the second fluid-flow passageway.

Abstract: A combination anti-reflux valve and gas venting device for use in a urinary drainage bag is described. In the preferred embodiment, the device is made of a flapper valve having a gas venting portion inside the urinary drainage bag. The flapper valve is connected to a gas venting connector means for passage of gas between the outside and inside connector means.

Abstract: A liquid meter assembly for collecting, metering and monitoring liquid is disclosed. The assembly comprises a container for collecting the liquid, an electrically powered strain gauge suspension device for supporting the container and for determining the weight of the liquid collected in the container and a handle on the container for interconnecting with the strain gauge suspension device. A length of tubing is attached to the container and adapted for interconnecting with the source of the liquid. A tubing support system is included on the strain gauge suspension device for fixedly supporting the tubing to substantially inhibit influence on weight determination due to any movement thereon. A power supply is included in the assembly for supplying power to the strain gauge suspension device.

Abstract: A lock for a syringe which typically may be used with an aspirating biopsy needle. A malleable sheet defining a central, cutaway portion extending through the edge of the sheet and having foldable tabs positioned on the outer edge of the sheet is carried on a syringe barrel and may be used to lock the syringe plunger in a predetermined position. Thus a vacuum may be drawn in the syringe by the plunger with the plunger then being locked to provide suction to the aspirating biopsy needle.

Abstract: Medium chain triglyceride containing lipid emulsions for the nutrition of liver diseased or septicemic patients are improved by the inclusion in the emulsions of long chain triglycerides. The emulsions may also contain amino acids in proportions desirable for the nutrition of liver diseased patients, as well as carbohydrates, drugs, vitamins and electrolytes.

Abstract: A hemostatic clip device capable of being mounted to a surgical applicator and applied to a blood vessel so as to prevent blood flow. The clip device includes a pair of semi-rigid legs having free ends and opposed ends connected to a bridge. The legs are movable from an open mode in the applicator to a closed mode pinching the blood vessel. A plurality of first grooves are formed in parallel on one of the legs in a slanted direction relative to longitudinal dimension of the legs. A plurality of second grooves are formed in parallel on the other leg in a slanted direction relative the dimension of the legs approximately perpendicular to the second grooves so that the crimped vein remains stationary. A locking tab formed at the end of one of the legs is adapted to slide into a recess at the inner side of the opposed leg to prevent cross movement of the legs.

Abstract: Synthetic polyesters are employed as calorie sources for parenteral or enteral nutrition. The polyesters are hydrolyzed and respired by the body and offer the advantage of high calorie density when compared to conventional or other synthetic calorie sources.