Patents Represented by Attorney, Agent or Law Firm Robert M. Bedgood
  • Therapeutic suppression of specific immune response by administration of oligomeric forms of antigen of controlled chemistry
    Patent number: 6375951
    Abstract: The invention features a non-immunogenic construct for reducing a non-primary antibody response to an epitope of a T-dependent antigen. The construct is free of high molecular weight immunostimulatory molecules and contains copies of the epitope which bind to a B cell membrane immunoglobulin receptor specific for the epitope but fail to form an imnunon.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: April 23, 2002
    Assignee: Johns Hopkins University
    Inventors: Howard M. Dintzis, Renée Z. Dintzis, James K. Blodgett, John C. Cheronis, Gary Kirschenheuter
  • Therapeutic suppression of specific immune response by administration of oligomeric forms of antigen of controlled chemistry
    Patent number: 6340460
    Abstract: A method of making a non-immunogenic construct for reducing a non-primary antibody response to an epitope of a T-dependent antigen by coupling two or more copies of the epitope to a nonimmunogenic soluble carrier to yield a conjugate preparation and removing high molecular weight immunostimulatory molecules.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: January 22, 2002
    Inventors: Howard M. Dintzis, Renee Z. Dintzis