Abstract: A cyclosporin of the formula ##STR1## wherein A is a residue of the formula ##STR2## wherein R is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or C.sub.1-3 alkylthio; halo-substituted-C.sub.1-3 alkyl, -C.sub.1-3 alkoxy or -C.sub.1-3 alkylthio; hydroxy-substituted-C.sub.1-3 alkyl, -C.sub.2-3 alkoxy or -C.sub.2-3 alkylthio; or amino or mono- or di-(C.sub.1-2 alkyl)-amino,X is oxygen or sulphur,--x--y-- is --CH.dbd.CH-- (trans) or --CH.sub.2 --CH.sub.2 --,B is -.alpha.Abu-, -Val-, -Thr- or -Nva- andQ is -(D)Ala-; -(D)Ser-; -[O-(2-hydroxyethyl)(D)Ser]-; or -[O-acyl(D)Ser]- or -[O-(2-acyloxy ethyl)(D)Ser]-in which the acyl residue is physiologically hydrolysable and acceptable, are useful in the topical treatment of asthma.

Abstract: The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of formula ##STR1## wherein R is hydrogen, a negative charge or a silyl protecting group, R.sub.o is hydrogen or methoxy, R.sub.1 is hydrogen or a silyl protecting group and X is the radical of a nucleophile, and their acid addition salts.

Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.

Abstract: Novel amidine salts of 7-Amino-3-hydroxymethyl-3-cephem-4-carboxylic acid (=HACA), particular guanidine and diaza-bicyclo-alkylene salts, are useful as intermediates in the synthesis of cephalosporins.

Abstract: The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

Abstract: The invention provides a process for the production of azodyes and their derivatives by diazotization and coupling reactions and optionally further modification reactions, wherein a compound of formula ##STR1## in which E signifies an aromatic bivalent radical,X.sub.1 signifies hydroxy or a primary amino group,Y.sub.1 signifies hydroxy or a primary amino group and in which the aminogroup linked to the --SO.sub.2 -bound phenyl radical may optionally be acylated,or a mixture of compounds of formula (I), is employed as a coupling component or/and--in the non-acylated form--as a diazo component,the invention in particular relates also to the novel dyes and their use and to the novel intermediates.

Abstract: The present invention provides a method of increasing the sun protection factor (SPF) rating of a fiber or fabric, comprising the steps of providing a UVR absorber, applying the UVR absorber to a fabric, whereby the UVR absorber is attached to the fiber and an application of less than 3% UVR absorber on weight of fiber produces an SPF rating of greater than 20 for the UVR absorber and fabric combination.

Abstract: An infusion apparatus includes a pump and a fluid delivery set. The infusion apparatus is adapted to monitor the fluid delivery set for insuring proper placement in relation to the pump. The infusion apparatus further includes a sensor which operates to detect the proper alignment of the fluid delivery set and also the proper operating position of the infusion apparatus. The infusion apparatus includes a cover which is adapted to be in a closed position when the infusion apparatus is in proper operating position. The cover operates to secure the fluid delivery set within the mounted position in the infusion apparatus.

Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.

Abstract: A modified steamer (D) comprising a heatable conduit (5), through which a substrate (S) can be introduced into the steamer (D) so that the substrate (S) can be preheated directly prior to contact with the steam.

Abstract: A method of controlling the hydration of a cementitious composition comprising the steps of:i) providing a cementitious composition containing an amount of a neutralized salt of an alpha-monohydroxy carboxylic acid effective to retard the cementitious composition, said carboxylic acid containing two or more carboxylic acid groups, and subsequently,ii) adding an additional amount of said neutralized salt of an alpha monohydroxy carboxylic acid or a second neutralized salt of an alpha monohydroxy carboxylic acid in an amount sufficient to activate hydration of the retarded cementitious composition, said cementitious composition comprising hydraulic binder and water.

Abstract: The disperse dyes of formula I ##STR1## wherein the symbols D, K, R.sub.3-5, R.sub.10, m, z, n and Y possess the significances given in claim 1, are eminently suitable for dyeing or printing hydrophobic, fully or semi-synthetic, organic fiber materials.

Abstract: Improved processes for the exhaust dyeing of cellulosic fibers with sulphur dyes in the presence of non-sulphide reducing agents wherein the dyeing of the textile substrate is performed in a closed vessel in an atmosphere of reduced oxygen level and then oxidizing.

Abstract: A method of rapidly forming in place a cementitious structure comprising mixing a cement composition with an amount of a water soluble citrate effective to accelerate the setting of the cement in the presence of sufficient water for hydraulic setting of the cement, and delivering the resulting composition while fluid to the place for forming the cementitious structure.

Abstract: This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.

Abstract: A gastrostomy feeding tube removal device is comprised of a hollow cylindrical body, a conical head formed at one end and preferably a cap or top at the other to assist in grasping the tool during use. A sheath covers the remaining body portion and is slideably moveable thereon. In use, the gastrostomy tube is pulled through the device which enters the stomach through an ostomy of the patient. Upon contacting the retention bolster means proximate the inner stomach lining, the plastic sheath is pressed forward against the extended members of the retention means thereby collapsing them and withdrawing them into the sheath. The device is then withdrawn from the patient's body simultaneously removing the tube as well.

Abstract: A liquid dyestuff composition comprising a solvent-soluble dyestuff and a water miscible organic solvent, the composition comprising over 25% by weight of dissolved dyestuff.

Abstract: The invention concerns azole compounds of formula ##STR1## wherein the substituents have various significances, in free form or salt form.They can be prepared e.g. by acylation, or by aziridine or oxazole ring opening.The compounds can be used as pharmaceuticals, especially as selective inhibitors of the 25-hydroxyvitamin D3--hydroxylases in the treatment of disorders of proliferation and differentiation in vitamin D--responsive tissues.

Abstract: (A) oligohydroxy-C.sub.3-8 -alkanes containing at least 3 hydroxy groups and (B) KOH, that contain at least 5% by weight of K.sup.+ and at least one alcoholic hydroxy group are eminently suitable as oxyalkylation catalysts, in particular for the oxyalkylation of ester group-containing substrates, before all of natural, vegetable or animal fats or oils or their modification products.

Abstract: Process of depleting 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid in Z/E mixtures of 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acida) by subjecting an amine salt of a Z/E mixture of 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephen-4-carboxylic acid to crystallization and converting this amine salt into 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid, orb) by subjecting the Z/E mixture to chromatography.