Abstract: A maneuverable, brakeable, roll resistant high performance snow sled suitable for use on downwardly sloping terrain. The preferred embodiment of the sled embodies a tandem, mirror image, in-line suspension and shock absorbing system connecting the main frame member upon which a seat is mounted to a snow board type runner. Roll stability is achieved utilizing stabilizer wings attached to each side of the main frame member embodying a torsion resistance mechanism. Speed control, stopping and turning of the sled is accomplished utilizing an independently operable braking system.

Abstract: Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

Abstract: Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

Abstract: The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2-Deoxy-6-O-[2-deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoy l]-2-[(R)-3-octadecanoyloxytetradecanoylamino]-.beta.-D-glucopyranosyl]-2-[ (R)-3-hexadecanoyloxytetradecanoylamino]-D-glucopyranose and pharmaceutically acceptable salts thereof. The compound is not immunoreactive, not pyrogenic, not toxic but is active in ameliorating tissue damage due to ischemia/reperfusion injury. Methods for using the subject compound to protect against reversible and irreversible damage due to ischemia/reperfusion injury are also disclosed.

Abstract: Methods and compositions for treating type I immunoglobin E (IgE)-dependent hypersensitivity by the administration of monophosphoryl lipid A (MLA) or 3-deacylated monophosphoryl lipid A (3D-MLA) are disclosed. MLA or 3D-MLA administered alone or in combination with an allergen to a patient suffering from type I hypersensitivity reduces levels of total or allergen specific IgE and increases levels of IgG antibody in that patient. MLA and 3D-MLA can be administered as part of a desensitization regimen or as a component of a prophylactic vaccine to prevent a type I hypersensitivity reaction.

Abstract: A fluid transfer device utilizing a rotatable value assembly attached to two hollow core needles, which employs atmospheric air pressure to assist with the withdrawal of fluid from a first rubber stoppered container and during instillation of fluid into a second rubber stoppered container, permits air displaced from the second container to be evacuated therefrom. The device enables fluid to be withdrawn from a stoppered bottle with ease by eliminating the build up of a negative pressure in the bottle. Conversely, during instillation of fluid into a stoppered bottle, the device eliminates the build up of a positive pressure therein by the venting of displaced air.

Abstract: Organic compounds containing multiple ester groups are used in dry powder aerosol antiperspirant compositions to give greater antiperspirant effectiveness and act as a carrier for powder aluminum chlorhydroxide particles to the skin and to prevent clogging. The preferred esters are characterized by having from 12 to 16 carbon atoms and a ratio of ester groups to the number of carbon atoms of from about 0.125 to about 0.214. Diisopropyl adipate is most preferred.