Patents Represented by Attorney Roy J. Klostermann
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Patent number: 5672332Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 allkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.Type: GrantFiled: May 13, 1996Date of Patent: September 30, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Ella Y. Fung, Raghavan Rajagopalan
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Patent number: 5633372Abstract: The present invention relates particularly to novel heterocycle based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 10, 1995Date of Patent: May 27, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Ananthachari Srinivasan
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Patent number: 5623077Abstract: The present invention relates particularly to novel imidazole based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.Type: GrantFiled: April 10, 1995Date of Patent: April 22, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Ananthachari Srinivasan
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Patent number: 5607055Abstract: The present invention relates to packages for flexible products, especially medical products, wherein the package maintains the product in a desired configuration without kinking and allows for easy withdrawal of the product from the package. In a preferred embodiment, the present invention relates to a package for a medical catheter, the package having vacuum-formed ridges providing longitudinal stability to the package without interfering with the ability to easily remove the product from the package. The present invention further relates to methods of packaging flexible products using the packages according to the present invention.Type: GrantFiled: March 14, 1995Date of Patent: March 4, 1997Assignee: Mallinckrodt Medical, Inc.Inventor: George E. Bettinger
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Patent number: 5560901Abstract: The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a hydroxyapatite-like matrix as the radiolabelled synovectomy agent in a sufficient amount to provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.Type: GrantFiled: March 21, 1994Date of Patent: October 1, 1996Assignee: Mallinckrodt Medical, Inc.Inventors: James W. Brodack, Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco
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Patent number: 5019371Abstract: The compound N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6 -triiodoisophthalamide and similar such compounds may be used as x-ray contrast agents which are water-soluble, safe and in an aqueous solution are non-viscous. Methods of preparing N-(2,3-dihydroxypropyl)-5-[N-(2-hdyroxyethyl)glycolamido]-N'-methyl-2,4,6- triiodoisophthalamide are provided.Type: GrantFiled: November 21, 1990Date of Patent: May 28, 1991Assignee: Mallinckrodt Medical, Inc.Inventors: Youlin Lin, Rebecca A. Wallace, David H. White
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Patent number: 4997983Abstract: A process for the production of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisopht alamide wherein a mixture of 1,1,2-trichloroethane and 5-[(N-(2-acetoxyethyl)acetoxyacetamido]N,N'-bis(2,3-diacetoxypropyl)-2,4,6 -triiodoisophthalamide (hexaacetate) is distilled to remove 1,1,2-trichloroethane, at least a part of which is distilled as an azeotrope with water, so that a solvent exchange is effected to produce a mixture of hexaacetate in water. Hydrolysis of hexaacetate produces the desired product.Type: GrantFiled: January 31, 1990Date of Patent: March 5, 1991Assignee: Mallinckrodt, Inc.Inventor: William Z. McCarthy
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Patent number: 4991633Abstract: A sanitary packaging system and method of using the same for the packaging of a sanitary product comprising a sanitary housing portion, a product bag, a sliding adjustment tube and a product tube. The product tube extends inside the sanitary housing portion and is flexibly attached to the sliding adjustment tube to which the product bag is attached. The sanitary product under pressure passes through the product tube, sliding adjustment tube and into the product bag to complete packaging. Sanitized air is blown through the sanitary housing enclosure to create a positive pressure therein, whereby in the case of a leak within the product bag, sliding adjustment tube or product entry tube, sanitary product leaks outwardly therefrom rather than allowing contaminates to be pulled inwardly and contaminate said sanitized product.Type: GrantFiled: January 31, 1990Date of Patent: February 12, 1991Assignee: Mallinckrodt, Inc.Inventor: David M. Wong
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Patent number: 4973772Abstract: A process is disclosed for preparing fluoroaromatic compounds (such as fluoronitrobenzene compounds) by reaction of corresponding chloroacromatic compounds (such as chloronitrobenzene compounds) with alkali metal fluoride salts in the presence of alkyldiorganoaminopyridinium salts as phase transfer catalysts. A tertiary carbon atom is directly attached to the alkyl carbon atom which is directly attached to the ring nitrogen atom. A preferred catalyst is N-neopentyl-4-(4'-methylpiperidinyl)pyridinium chloride.Type: GrantFiled: February 7, 1987Date of Patent: November 27, 1990Assignee: Mallinckrodt, Inc.Inventor: Gary L. Cantrell
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Patent number: 4925650Abstract: The invention relates to a technetium-99m complex of the general formula ##STR1## wherein Z is a sulphur atom or an amino group of the general formula R.sub.17 --N--(R.sub.18).sub.k, in which k is 0 or 1 and R.sub.17 and R.sub.18 have the same meanings as the symbols R.sub.1 -R.sub.16 ;each of the symbols R.sub.1 -R.sub.16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkly group having 0-4 carbon atoms;and R.sub.5 together with R.sub.6 or R.sub.9 together with R.sub.10 additionally may form an oxygen atom;Tc represents technetium-99m;t is 0 or 1; andn is 0 or 1;with the provisos that(a) if R.sub.15, R.sub.16, R.sub.17 and/or R.sub.18 are/is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms;(b) at least one of the symbols R.sub.1 -R.sub.Type: GrantFiled: November 16, 1988Date of Patent: May 15, 1990Assignee: Mallinckrodt, Inc.Inventors: Dennis L. Nosco, Alfons M. Verbruggen
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Patent number: 4911921Abstract: A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.Type: GrantFiled: February 2, 1989Date of Patent: March 27, 1990Assignee: Mallinckrodt, Inc.Inventors: Larry E. Denton, Anil M. Salepkar
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Patent number: 4898976Abstract: The ethanolamine salt of N-nitrosophenylhydroxylamine ("NPHA") is effective as a polymerization inhibitor for ethylenically unsaturated monomers. The ethanolamine salt can be prepared by reacting ethanolamine with the ammonium salt of NPHA. Advantageously, the ethanolamine salt is soluble in high concentrations in water and a variety of polar organic solvents.Type: GrantFiled: April 17, 1989Date of Patent: February 6, 1990Assignee: Mallinckrodt, Inc.Inventor: John W. Varwig
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Patent number: 4843169Abstract: Alpha-arylalkanoic esters are prepared by reacting a trivalent iodine compound of the formula ##STR1## wherein Ar is an aromatic hydrogen and X and Y each represent a group which can be removed as an anion, with a carbonyl compound of the formula ##STR2## where Ar.sup.1 is an aromatic hydrocarbon, R is a hydrogen atom or an alkyl group, and R.sup.1 is a hydrogen atom or an alkyl group, in the presence of an orthocarboxylic ester having the general formula ZC(OR.sup.2).sub.3, wherein R.sup.2 is an alkyl group and Z is a hydrogen atom or an alkyl group; the reaction being carried out in the presence of sulfuric acid in an amount from about 0.2 to about 0.8 mole per mole of the carbonyl compound.Type: GrantFiled: July 21, 1986Date of Patent: June 27, 1989Assignee: Mallinckrodt, Inc.Inventor: Robert C. Chapman
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Patent number: 4806675Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-dodecylthiopro pionate] and (II) pentaerythritol bis[-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopro pionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenylalkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.Type: GrantFiled: October 19, 1987Date of Patent: February 21, 1989Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi
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Patent number: 4569959Abstract: Isocyanurate esters of thioalkanoamidophenols useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reacting an appropriate isocyanurate trithiol, which is a selected tris-mercapto alkanoic acid ester of tris-(2-hydroxyethyl) isocyanurate with an appropriate alkenyl compound, which is a selected N-alkenoyl[4-amino-(mono- or dialkyl)phenol] or, where the alkano moiety is a sole methylene group, by reaction of tris-(2-hydroxyethyl) isocyanurate with an appropriate [mercapto-N-(mono- or di-alkyl-4-hydroxyphenylalkanamide alkenoic] acid. In a preferred embodiment, the ester is 1,3,5-tris{2-hydroxy ethyl-[3-mercapto-(3',5'-di tert-butyl-4'-hydroxypropionanilide)]propionate}isocyanurate.Type: GrantFiled: January 17, 1985Date of Patent: February 11, 1986Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi, Henry J. Buehler
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Patent number: 4560574Abstract: A salt substitute composition is disclosed which includes a blend comprising:(a) potassium chloride(b) maltodextrin and(c) sodium chloride.In an embodiment, cream of tartar is further included in the salt substitute composition.Type: GrantFiled: June 30, 1983Date of Patent: December 24, 1985Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer
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Patent number: 4556577Abstract: A salt substitute composition is disclosed which includes a blend consisting essentially of:(a) potassium chloride and(b) maltodextrin.Type: GrantFiled: June 30, 1983Date of Patent: December 3, 1985Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer
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Patent number: 4556568Abstract: A salt substitute composition is disclosed which includes coated particles, each particle comprising:(a) a core comprising potassium chloride and(b) a coating on the core, the coating including a mixture containing:(i) maltodextrin and(ii) cream of tartar (potassium bitartrate) and(iii) optionally, sodium chloride.Also disclosed is a process for preparing a salt substitute composition which includes spraying an aqueous solution containing cream of tartar and maltodextrin (and sodium chloride, if included) onto an agitated and heated bed of particles including potassium chloride.Type: GrantFiled: June 30, 1983Date of Patent: December 3, 1985Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer
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Patent number: 4556567Abstract: A salt substitute composition is disclosed which comprises coated particles, each particle comprising:(a) a core comprising potassium chloride and(b) a coating on the core, the coating comprising maltodextrin and being free of sodium chloride.Also disclosed is a process for preparing a salt substitute composition which includes spraying an aqueous solution containing maltodextrin onto an agitated and heated bed of particles including potassium chloride.Type: GrantFiled: June 30, 1983Date of Patent: December 3, 1985Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer
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Patent number: 4556578Abstract: A salt substitute composition is disclosed which includes a blend comprising:(a) potassium chloride,(b) maltodextrin and(c) cream of tartar (potassium bitartrate)and being free of sodium chloride.Type: GrantFiled: June 30, 1983Date of Patent: December 3, 1985Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer