Abstract: There is disclosed a sanitary strip for drinking vessels which can be attached or affixed to the lip area of a drinking vessel to prevent the transfer of germs, bacteria, viruses, and other contaminants to the user of the drinking vessel. The sanitary strip is contained in a unitary, composite article having two peelably removable plys that overlay and are coextensive with the sanitary strip so that the sanitary strip is sandwiched by and between the peelably removable plys.

Abstract: There is disclosed a gutter trap assemblage which is adapted for use with conventional, U-shaped gutters and their downspouts. The gutter trap assemblage is an integral, one piece unit having an upper section and a lower section. When installed, the upper section mates with and communicates with a conventional U-shaped gutter and the lower section communicates with a conventional gutter downspout. The upper section also communicates with the lower section through its open bottom which is co-extensive with the open top of the lower section. A plurality of screens are provided in the lower section to form a series of chambers therein. The screens are positioned so that their top edges are below the plane of the bottom wall of a conventional, U-shaped gutter.

Abstract: There is disclosed a system and assemblage for producing microtexturized surfaces on implants for use in vertebrate animals, including humans and on substrates for use in growing and developing tissues and/or cells in vitro. By using the disclosed system and assemblage, the geometric configuration and the dimensions of the microtexturized surfaces can be pre-determined to impart a customized design texture on the implant or substrate surface thereby optimizing implant acceptance by and durability in the host tissue and the in vitro promotion of the growth and development of various types of cell tissue on substrates.

Abstract: A sun shield for a motor vehicle comprising three flexible panels sized in the shape of a windshield and two side window assemblies of the motor vehicle. The flexible panel of the windshield has a vertical central top slit to accommodate a rearview mirror holder. A plurality of VELCRO fasteners are for securing the three flexible panels at their perimeters about an interior frame of the windshield and the two side window assemblies, so as to cover the windshield and the two side window assemblies, to block out sunlight and reflected heat from entering the motor vehicle through the windshield and the two side window assemblies.

Abstract: There is disclosed a pail bailer having a continuous wall, an open top and a bottom that has a flood port formed therein and which is fitted with a flood screen and an internal flexible flapper valve overlying the flood port. The flapper valve is provided with a spacer bushing that permit it to flex away from the flood port when the pail bailer is lowered into water or other liquid to permit the water or other liquid to enter and fill the pail bailer. A handle is provided across the open top of the pail bailer and its ends are secured in diametrically opposed brackets enabling the handle to be rotated through an arc greater than 180.degree. or be locked within the brackets in vertical, coaxial alignment with the longitudinal axis of the pail bailer.

Abstract: Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Abstract: Novel fungicidal compositions comprising a pyranyl glycine ester compound and a .beta.-lactone compound and a method for controlling mycotic infections is disclosed.

Abstract: There is disclosed an automated system for testing the sterility of products intended for human health administration or for human consumption. The system permits a plurality of samples of a product to be concurrently tested and is arranged so that multiple samples of a product to be tested can be mixed and then conveyed to test canisters along with appropriate growth media prior to determining that the product is sterile or is free from microbial contamination.

Abstract: There is disclosed a medication container which is adapted to be side loaded with unit doses of medication during packaging operations. After being filled with the unit doses of medication, the container side is sealed. The medication doses can be removed by a user from the sealed container by means of a removable closure at one end of the container.

Abstract: Described is a new process for selectively acylating FK-506 type immunosuppressant macrolides, including immunomycin (FK-520), in the C-32 position, under novel conditions utilizing an immobilized lipase enzyme, an acyl donor, and a dry, non hydroxylic organic solvent. The enzyme is absorbed onto a solid support and the enzyme/support catalyzes the C-32 acylation. The enzyme/support complex can then be filtered from the reaction mixture and, recycled for use.

Abstract: There is disclosed a child resistant cap and container assemblage comprising a container and a cap member that is secured to the container so that it can not be removed without either breaking the cap member or damaging the seal that joins the cap member to the container. The cap member is provided with a nozzle having an internal locking means so that the contents of the container can not be accessed when the container is in its normal upright position. To access the contents in the container, the assemblage is titled to disengage the locking means enabling the nozzle to be opened and permitting a user to access the contents of the container using only one hand.

Abstract: There is disclosed a monophosphorylated cyclic lipopeptide compound obtained by biophosphorylating a cyclic lipopeptide related to echinocandins and having a peptide skeleton bearing several hydroxy groups wherein in the phosphorylated cyclic lipopeptide, the phosphate group is attached to the hydroxy group of the 4-hydroxyproline component of the lipopeptide. The compounds are useful for the control of fungi and parasites.

Abstract: 17.beta.-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5.alpha.-reductase inhibitors of the formula: ##STR1## wherein R is C.sub.3 -C.sub.8 cycloalkyl, which can be substituted with C.sub.1 -C.sub.4 alkoxy or C.sub.6 -C.sub.12 aryl, which can be substituted with one or more of: --OH, --OC.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkyl, --(CH.sub.2).sub.m OH, --(CH.sub.2).sub.n COOH, including protected --OH, where m is 1-4, n is 1-3, and pharmaceutically acceptable salts or esters thereof. Also described is a pharmaceutical formulation. The above compounds are active as testosterone 5.alpha.-reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

Abstract: Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Abstract: There are disclosed a method and an assemblage for controlling and managing lower explosion levels of those products containing volatile or combustible materials which can create a potentially explosive or combustible atmosphere when such products are dried or subjected to further processing in an oven or furnace.

Abstract: A child resistant unit dose package for medications comprises a container member having concealed locking means, a plurality of cavities along its longitudinal axis for holding medication, each cavity closed with a peel-off seal, and a cover for the container member that requires two operations to open. In another embodiment, a separate drug container is disclosed which does not include a cover.