Patents Represented by Attorney, Agent or Law Firm Scott B. Feder
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Patent number: 6653505Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: GrantFiled: April 23, 2001Date of Patent: November 25, 2003Assignees: The United States of America as represented by the Secretary of Agriculture, The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Patent number: 6576253Abstract: The present invention provides food bars for consumption by pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant containing one or more vitamins and/or minerals, DHA, one or more DHA taste-masking agents and, optionally, one or more anti-constipation and regularity-maintaining agents, methods for preparing these food bars, and methods for supplementing the dietary requirements of pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant.Type: GrantFiled: February 19, 2002Date of Patent: June 10, 2003Assignee: PBM Pharmaceuticals, Inc.Inventors: Paul B. Manning, Jack H. Schramm, James W. McGrath, Jr.
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Food bars containing nutritional supplements and anti-constipation and regularity maintaining-agents
Patent number: 6569445Abstract: The present invention provides food bars for consumption by pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant containing one or more vitamins and/or minerals, and one or more anti-constipation and regularity-maintaining agents, methods for preparing these food bars, and methods for supplementing the dietary requirements of pregnant women, lactating women or women of childbearing potential that are attempting to become pregnant.Type: GrantFiled: December 5, 2000Date of Patent: May 27, 2003Assignee: PBM Pharmaceuticals, Inc.Inventors: Paul B. Manning, Jack H. Schramm, James W. McGrath, Jr. -
Patent number: 6545052Abstract: A method is provided for inhibiting free radical degradation in the skin of a human or nonhuman animal comprising contacting the skin with a skin treatment composition having a concentration of a 1-(3-methoxybenzyl)-3-substituted thiourea compound effective for inhibiting free radical generation. Skin protecting compositions comprising a free radical inhibiting concentration of a 1-(3-methoxybenzyl)-3-substituted thiourea compound, and optionally a sunscreeen composition, are also provided.Type: GrantFiled: November 29, 2000Date of Patent: April 8, 2003Assignee: Fan Tech, Ltd.Inventors: Alan Wohlman, Anthony J. O'Lenick, Jr.
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Patent number: 6544349Abstract: A method is provided for in situ cleaning of lubricated parts of a machine in which the machine is operated with a lubricating fluid that contains an effective concentration of a cleaning composition comprising a synthetic ester of a naturally occurring fatty acid for an amount of time sufficient to remove from the lubricated parts adhered debris which is not removed by the lubricating fluid conventionally used in the machine.Type: GrantFiled: November 16, 2000Date of Patent: April 8, 2003Assignee: The Fanning CorporationInventors: Donald R. Donahue, Frank J. Miller
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Patent number: 5516917Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R.sup.1 is alkyl;R.sup.2 represents alkyl from 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl from 1 to 5 carbon atoms;R.sup.6 is alkyl;n is 1 to 5;p is 0 to 6;x is 0 or 2; andR.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.Type: GrantFiled: June 8, 1994Date of Patent: May 14, 1996Assignee: G. D. Searle & Co.Inventors: Steven W. Djuric, Stella S. Yu
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Patent number: 5508309Abstract: This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH--, or --CH.dbd.N--;wherein R.sup.1 is --CO.sub.2 R.sup.2 or tetrazole;wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation;wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons;wherein p and q are integers from 0 to 20;wherein n is 0 or 1; andwherein m is 0, 1, 2, or 3.Type: GrantFiled: July 1, 1994Date of Patent: April 16, 1996Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Richard A. Haack, Julie M. Miyashiro
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Patent number: 5439937Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R.sup.1 is alkyl;R.sup.2 is hydrogen, alkyl;R.sup.6 is alkyl;n is 1 to 5;p is 0 to 6;x is 0 or 2; andR.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.Type: GrantFiled: March 3, 1994Date of Patent: August 8, 1995Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Stephen H. Docter, Stella S. Yu
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Patent number: 5401645Abstract: A process for producing N-substituted amino compounds, a process for oxidizing an N-substituted amino compound with a microbe, or cell fragment or cell free extract thereof, and a process for oxidizing an N-substituted amino compound with a microbe, or cell fragment or cell free extract thereof and reducing the oxidized N-substituted amino compound to N-substituted-polyhydroxy piperidines based on N-substituted mannosamines, allosamines and altrosamines, N-substituted polyhydroxy pyrrolidines, and N-substituted polyhydroxy azetidines. In addition, a one pot process for producing N-substituted-polyhydroxy piperidines based on N-substituted mannosamines, allosamines and altrosamines, N-substituted polyhydroxy pyrrolidines, and N-substituted polyhydroxy azetidines from the respective sugar is disclosed.Type: GrantFiled: March 16, 1992Date of Patent: March 28, 1995Assignees: Monsanto Company, G. D. Searle & Co.Inventors: Roy W. Grabner, Bryan H. Landis, Mike G. Scaros, Rick J. Rutter
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Patent number: 5380740Abstract: This invention encompasses compounds of the following formula and the stereoisomers and pharmaceutically acceptable salts thereof. ##STR1## wherein R represents lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or --(CH.sub.2).sub.m --R.sup.3 wherein R.sup.3 represents cycloalkyl of 3 to 5 carbon atoms and m is 1, 2 or 3; R.sub.1 is --CONH.sub.2 or ##STR2## NHSO.sub.2 R.sub.2 wherein R.sub.2 is lower alkyl, phenyl, unsubstituted or substituted with loweralkyl, or ##STR3## and n is an integer from 2 to 5. The compounds are useful anti-inflammatory agents for treating, for example, inflammatory bowel disease, rheumatoid arthritis, gout, asthma and psoriasis.Type: GrantFiled: April 28, 1993Date of Patent: January 10, 1995Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Donald J. Fretland, Stella S. Yu
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Patent number: 5360907Abstract: The present invention relates to compounds of the formula ##STR1## wherein HET is either ##STR2## and pharmaceutical compositions containing a therapeutically effective amount of the compounds in combination with a pharmaceutically acceptable carrier and a method for treating diseases mediated by platelet activating factor.Type: GrantFiled: June 14, 1993Date of Patent: November 1, 1994Assignee: G.D. Searle & Co.Inventors: Kirk T. Lentz, Richard M. Weier
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Patent number: 5356919Abstract: This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CH.dbd.CH--, or --CH.dbd.N--; wherein R.sup.1 is --CO.sub.2 R.sup.2 or tetrazole; wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R is an alkyl of from 1 to 20 carbons, --(CH.sub.2).sub.p CF.sub.3 or --(CH.sub.2).sub.q R.sup.3 wherein R.sup.3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons; wherein p and q are integers from 0 to 20; wherein n is 0 or 1; and wherein m is 0, 1, 2, or 3.Type: GrantFiled: May 30, 1991Date of Patent: October 18, 1994Assignee: G. D. Searle & Co.Inventors: Stevan W. Djuric, Richard A. Haack, Julie M. Miyashiro
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Patent number: 5310951Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R.sup.1 is alkyl;R.sup.2 is hydrogen, alkyl;R.sup.6 is alkyl;n is 1 to 5;p is 0 to 6;x is 0 or 2; andR.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.Type: GrantFiled: December 23, 1992Date of Patent: May 10, 1994Assignee: G.D. Searle & Co.Inventors: Stevan W. Djuric, Stephen H. Docter, Stella S. Yu